Q8L165 · Q8L165_GEOSE
- ProteinRibonuclease HII
- GenernhB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids259 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
Catalytic activity
Cofactor
Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )
Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | ribonuclease H2 complex | |
Molecular Function | manganese ion binding | |
Molecular Function | RNA binding | |
Molecular Function | RNA-DNA hybrid ribonuclease activity | |
Biological Process | DNA replication, removal of RNA primer | |
Biological Process | mismatch repair |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonuclease HII
- EC number
- Short namesRNase HII
Gene names
Organism names
- Taxonomic lineageBacteria > Bacillota > Bacilli > Bacillales > Bacillaceae > Geobacillus
Accessions
- Primary accessionQ8L165
Subcellular Location
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 72-259 | RNase H type-2 | ||||
Sequence: ERIAGIDEAGRGPLAGPVVAASVILPPDAYLPGLDDSKRLTAAKREALFAQIEACAVAVGIGIVSAAEIDERNIYEATKQAMAKAVSALSPPPDYLLVDAMAVPCALPQRRLMKGDANSASIAAASIMAKVTRDRLMKELDRRYPQYGFARHMGYGTPEHLEAIRRYGITPEHRRSFAPVKEAAGVEN |
Sequence similarities
Belongs to the RNase HII family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length259
- Mass (Da)28,892
- Last updated2002-10-01 v1
- Checksum7A615C96BF7348D6