Q8L165 · Q8L165_GEOSE

Function

function

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.

Catalytic activity

  • Endonucleolytic cleavage to 5'-phosphomonoester.
    EC:3.1.26.4 (UniProtKB | ENZYME | Rhea)

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.

Features

Showing features for binding site.

125920406080100120140160180200220240
TypeIDPosition(s)Description
Binding site78a divalent metal cation (UniProtKB | ChEBI)
Binding site79a divalent metal cation (UniProtKB | ChEBI)
Binding site170a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribonuclease H2 complex
Molecular Functionmanganese ion binding
Molecular FunctionRNA binding
Molecular FunctionRNA-DNA hybrid ribonuclease activity
Biological ProcessDNA replication, removal of RNA primer
Biological Processmismatch repair

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonuclease HII
  • EC number
  • Short names
    RNase HII

Gene names

    • Name
      rnhB

Organism names

Accessions

  • Primary accession
    Q8L165

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain72-259RNase H type-2

Sequence similarities

Belongs to the RNase HII family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    259
  • Mass (Da)
    28,892
  • Last updated
    2002-10-01 v1
  • Checksum
    7A615C96BF7348D6
MKEYTVKEIEALLPELGGEDDPRWEMLRRDERKSVQALLARFVKQKEREKVMRRRWEELMRYERELYAAGIERIAGIDEAGRGPLAGPVVAASVILPPDAYLPGLDDSKRLTAAKREALFAQIEACAVAVGIGIVSAAEIDERNIYEATKQAMAKAVSALSPPPDYLLVDAMAVPCALPQRRLMKGDANSASIAAASIMAKVTRDRLMKELDRRYPQYGFARHMGYGTPEHLEAIRRYGITPEHRRSFAPVKEAAGVEN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB073670
EMBL· GenBank· DDBJ
BAB91155.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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