Q8KA71 · METE_BUCAP

Function

function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site17-205-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site1155-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site430-432L-homocysteine (UniProtKB | ChEBI)
Binding site430-432L-methionine (UniProtKB | ChEBI)
Binding site483L-homocysteine (UniProtKB | ChEBI)
Binding site483L-methionine (UniProtKB | ChEBI)
Binding site514-5155-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site5605-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site598L-homocysteine (UniProtKB | ChEBI)
Binding site598L-methionine (UniProtKB | ChEBI)
Binding site6045-methyltetrahydropteroyltri-L-glutamate (UniProtKB | ChEBI)
Binding site640Zn2+ (UniProtKB | ChEBI); catalytic
Binding site642Zn2+ (UniProtKB | ChEBI); catalytic
Binding site664Zn2+ (UniProtKB | ChEBI); catalytic
Active site693Proton donor
Binding site725Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Molecular Function5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
Molecular Functionzinc ion binding
Biological Processmethionine biosynthetic process
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase
  • EC number
  • Alternative names
    • Cobalamin-independent methionine synthase
    • Methionine synthase, vitamin-B12 independent isozyme

Gene names

    • Name
      metE
    • Ordered locus names
      BUsg_031

Organism names

Accessions

  • Primary accession
    Q8KA71

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000986201-7575-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    757
  • Mass (Da)
    88,098
  • Last updated
    2002-10-01 v1
  • Checksum
    637B1D9532325BCE
MTIFNHTLGFPRIGLNRELKKAQEDYWSGNLLYEDFLCVGSQLRRENWKKQKDAGIDYIPVGDFAWYDHVLSTSMMLGNIPERHLNVNDNKIDLDCLFRIARGCSPDVAASEMTKWFNTNYHYIVPEFNKNRILKFSWKQILEETDEALLLGYKVKPIILGPITYLWLGKIKGEYFDRLDLLKNILPIYKQVLRELSQRNIDFVQIDEPALVLDLPEKWKKAYSYAYEYLNGTTKILLTTYFDSIEHNIEYIRDLPIYGIHIDLVFGKYNLFDFNSKLPKEWILSLGVINGRNVWRADLIKLFKSISTILKFRKKLLIGSSCSLLHSPIDLQKEKNLDKESKKWFSFAVQKCTELSLLSKALNKNDTDSIQKWCSSIYERNFSKRVQKIEVQNRLSEILNVNFKRSDSYNIRSREQKKKFNLPILPTTTIGSFPQTLQIRKLRRDYKQGLINDVDYEIGIKKHIKEVIKEQEKLGIDVLVHGEPERNDMVEYFGENLDGFIFTDNGWVQSYGSRCVKPPIIIGDVSRLKPITVKWSKYAQSLTDKPVKAMLTGPVTILFWSFPREDISLEKIAKQIGLALRDEVLDLEKEKIEIIQIDEPALREGLPLRKSLWNEYLSWAVDAFRLSSSGVKNTTQIHTHMCYCEFHDIMHAISFLDADVITIETARSDMELLKSFKTFKYPNEIGPGVYDIHSSNIPSITSIKFLLNKAIAYIPVERIWVNPDCGLKTRNWNETILALKNMVCAAKEMRDKIKKIT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013218
EMBL· GenBank· DDBJ
AAM67602.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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