Q8K988 · LON_BUCAP

Function

function

ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.

Catalytic activity

  • Hydrolysis of proteins in presence of ATP.
    EC:3.4.21.53 (UniProtKB | ENZYME | Rhea)

Features

Showing features for binding site, active site.

1777100200300400500600700
Type
IDPosition(s)Description
Binding site356-363ATP (UniProtKB | ChEBI)
Active site679
Active site722

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular FunctionATP-dependent peptidase activity
Molecular Functionsequence-specific DNA binding
Molecular Functionserine-type endopeptidase activity
Biological Processcellular response to heat
Biological Processprotein quality control for misfolded or incompletely synthesized proteins

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Lon protease
  • EC number
  • Alternative names
    • ATP-dependent protease La

Gene names

    • Name
      lon
    • Ordered locus names
      BUsg_461

Organism names

Accessions

  • Primary accession
    Q8K988

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000761261-777Lon protease

Expression

Induction

By heat shock.

Interaction

Subunit

Homohexamer. Organized in a ring with a central cavity.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain11-204Lon N-terminal
Domain592-773Lon proteolytic

Sequence similarities

Belongs to the peptidase S16 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    777
  • Mass (Da)
    87,755
  • Last updated
    2002-10-01 v1
  • Checksum
    768ACD8B06713DD2
MNSERSERIKIPVLPLRDVVVYPHMVIPLFVGRKKSIHCIETSMNNDKKIMLIAQKEASKDEPSTNDLFNIGTISSILQMLKLPDGTVKVLVEGLQRACIKNIESNGEHLVAEVELIISPTVIDKEQEVLIRTTVNQFESYIKLNKKIPSEILNTLSQTKNAEKLADTIAAHMPLKLADKQSVLEIYNVNERLEFLMAIMETEIDLLKVEKRIRNRVKKQMEKSQREYYLNEQIKAIQKELGDMDEIPDENKILKRKIKSLKMPKEAKEKTESELQKLKMMSPMSAEATVVRSYIDWMIQVPWNIKTKIKKDIQEAKKILDIDHFGLEKVKERILEYLAVQSRTNKVKGPILCLIGPPGVGKTSLGKSIAKSTGRKYVRMALGGIRDEAEIRGHRRTYIGSMPGKLMQKMVKAKVKNPLFLLDEIDKMSCDIRVDPASALLEVLDPEQNINFNDHYLEVDYDLSDVMFVATSNSMNIPAPLLDRMEIIRLSGYTENEKLNIAKCYLYPKQMERNALKRNELIITDCAIISIIQYYTREAGVRSLEREISKICRKVVKLLILNKSLKKIEINSKNLKKFLGIKRFDYGKTNNLNQIGQVVGLAWTEVGGELLTIETACVSGKGKLTYTGSLGEVMQESIQAALTVVRSQAKKLGIKKDFHEKHDIHVHVPEGATPKDGPSAGIAMCTAIVSSLTKNPVKSNIAMTGEITLQGRVLTIGGLKEKLLAAHRGGVKTVLIPYENKRNLEEIPKNIIEGLTIYPVKNIEEVLKIALENTPYV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE013218
EMBL· GenBank· DDBJ
AAM68004.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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