Q8K592 · AMHR2_MOUSE
- ProteinAnti-Muellerian hormone type-2 receptor
- GeneAmhr2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids568 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity
- ATP + L-threonyl-[receptor-protein] = ADP + H+ + O-phospho-L-threonyl-[receptor-protein]
Cofactor
Mn2+ (UniProtKB | Rhea| CHEBI:29035 )
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | receptor complex | |
Molecular Function | anti-Mullerian hormone receptor activity | |
Molecular Function | ATP binding | |
Molecular Function | hormone binding | |
Molecular Function | metal ion binding | |
Molecular Function | protein homodimerization activity | |
Molecular Function | transforming growth factor beta receptor activity | |
Molecular Function | transforming growth factor beta receptor activity, type II | |
Biological Process | anti-Mullerian hormone receptor signaling pathway | |
Biological Process | blood vessel development | |
Biological Process | BMP signaling pathway | |
Biological Process | cellular response to growth factor stimulus | |
Biological Process | female gonad development | |
Biological Process | male gonad development | |
Biological Process | sex differentiation | |
Biological Process | transforming growth factor beta receptor signaling pathway |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnti-Muellerian hormone type-2 receptor
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8K592
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 16-147 | Extracellular | ||||
Sequence: QVSPNRRTCVFFEAPGVRGSTKTLGEMVDAGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCRDSDEPGCESLHCDPVPRAHPNPSSTLFTCSCGTDFCNANYSHLPPSGNQGAPGPQEPQATPGGPVWM | ||||||
Transmembrane | 148-168 | Helical | ||||
Sequence: ALLLLGMFLVLLLSSIILALL | ||||||
Topological domain | 169-568 | Cytoplasmic | ||||
Sequence: QRKACRVQGGSDPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPHGASSFPESPQGCPENCLSAPASAVFPCRPQQSSCLLSVQQGPGSRSPDPVGDTVQVYVNE |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-15 | |||||
Sequence: MLGTLGLWTLLPAAA | ||||||
Chain | PRO_0000260265 | 16-568 | Anti-Muellerian hormone type-2 receptor | |||
Sequence: QVSPNRRTCVFFEAPGVRGSTKTLGEMVDAGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCRDSDEPGCESLHCDPVPRAHPNPSSTLFTCSCGTDFCNANYSHLPPSGNQGAPGPQEPQATPGGPVWMALLLLGMFLVLLLSSIILALLQRKACRVQGGSDPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPHGASSFPESPQGCPENCLSAPASAVFPCRPQQSSCLLSVQQGPGSRSPDPVGDTVQVYVNE | ||||||
Disulfide bond | 55↔79 | |||||
Sequence: CLYSHCCFGIWNLTHGRAQVEMQGC | ||||||
Glycosylation | 66 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 92↔109 | |||||
Sequence: CDPVPRAHPNPSSTLFTC | ||||||
Glycosylation | 119 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 199-504 | Protein kinase | ||||
Sequence: LRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAAL |
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length568
- Mass (Da)61,195
- Last updated2006-11-28 v2
- ChecksumAE89AA1727600E5E
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8VHE2 | A0A2R8VHE2_MOUSE | Amhr2 | 61 | ||
F6V9X7 | F6V9X7_MOUSE | Amhr2 | 190 | ||
A0A2R8W6H9 | A0A2R8W6H9_MOUSE | Amhr2 | 448 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 240 | in Ref. 1; AAM28608 | ||||
Sequence: R → G |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF503863 EMBL· GenBank· DDBJ | AAM28608.1 EMBL· GenBank· DDBJ | mRNA | ||
BC119571 EMBL· GenBank· DDBJ | AAI19572.1 EMBL· GenBank· DDBJ | mRNA |