Q8K592 · AMHR2_MOUSE

  • Protein
    Anti-Muellerian hormone type-2 receptor
  • Gene
    Amhr2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site205-213ATP (UniProtKB | ChEBI)
Binding site226ATP (UniProtKB | ChEBI)
Active site329Proton acceptor

GO annotations

AspectTerm
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular Functionanti-Mullerian hormone receptor activity
Molecular FunctionATP binding
Molecular Functionhormone binding
Molecular Functionmetal ion binding
Molecular Functionprotein homodimerization activity
Molecular Functiontransforming growth factor beta receptor activity
Molecular Functiontransforming growth factor beta receptor activity, type II
Biological Processanti-Mullerian hormone receptor signaling pathway
Biological Processblood vessel development
Biological ProcessBMP signaling pathway
Biological Processcellular response to growth factor stimulus
Biological Processfemale gonad development
Biological Processmale gonad development
Biological Processsex differentiation
Biological Processtransforming growth factor beta receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Anti-Muellerian hormone type-2 receptor
  • EC number
  • Alternative names
    • Anti-Muellerian hormone type II receptor (AMH type II receptor)
    • MIS type II receptor (MISRII; MRII)

Gene names

    • Name
      Amhr2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K592
  • Secondary accessions
    • Q0VDQ4

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain16-147Extracellular
Transmembrane148-168Helical
Topological domain169-568Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-15
ChainPRO_000026026516-568Anti-Muellerian hormone type-2 receptor
Disulfide bond55↔79
Glycosylation66N-linked (GlcNAc...) asparagine
Disulfide bond92↔109
Glycosylation119N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with type I receptor ACVR1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain199-504Protein kinase

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    568
  • Mass (Da)
    61,195
  • Last updated
    2006-11-28 v2
  • Checksum
    AE89AA1727600E5E
MLGTLGLWTLLPAAAQVSPNRRTCVFFEAPGVRGSTKTLGEMVDAGPGPPKGIRCLYSHCCFGIWNLTHGRAQVEMQGCRDSDEPGCESLHCDPVPRAHPNPSSTLFTCSCGTDFCNANYSHLPPSGNQGAPGPQEPQATPGGPVWMALLLLGMFLVLLLSSIILALLQRKACRVQGGSDPEPGSGGDCSEELPELAELRFSQVIQEGGHAVVWAGRLQGEMVAIKAFPPRAVAQFRAERAVYQLLGLQHDHIVRFITAGQGGPGPLPSGPLLVLELYPKGSLCHYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQDGQYKPGIAHRDLSSQNVLIREDRSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGTALQRADVYSLALLLWEILSRCSDLRPDHRPPPFQLAYEAELGSNPSACELWALAVEERKRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPHGASSFPESPQGCPENCLSAPASAVFPCRPQQSSCLLSVQQGPGSRSPDPVGDTVQVYVNE

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2R8VHE2A0A2R8VHE2_MOUSEAmhr261
F6V9X7F6V9X7_MOUSEAmhr2190
A0A2R8W6H9A0A2R8W6H9_MOUSEAmhr2448

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict240in Ref. 1; AAM28608

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF503863
EMBL· GenBank· DDBJ
AAM28608.1
EMBL· GenBank· DDBJ
mRNA
BC119571
EMBL· GenBank· DDBJ
AAI19572.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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