Q8K4T5 · DUS19_MOUSE

  • Protein
    Dual specificity protein phosphatase 19
  • Gene
    Dusp19
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.

Catalytic activity

Activity regulation

Phosphatase activity is enhanced by Ca2+ and Mn2+.

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site149Phosphocysteine intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionJUN kinase phosphatase activity
Molecular FunctionMAP-kinase scaffold activity
Molecular Functionmitogen-activated protein kinase kinase binding
Molecular Functionmitogen-activated protein kinase kinase kinase binding
Molecular Functionmyosin phosphatase activity
Molecular Functionprotein kinase activator activity
Molecular Functionprotein kinase inhibitor activity
Molecular Functionprotein tyrosine phosphatase activity
Molecular Functionprotein tyrosine/serine/threonine phosphatase activity
Molecular Functionprotein tyrosine/threonine phosphatase activity
Biological ProcessJNK cascade
Biological Processnegative regulation of JNK cascade
Biological Processnegative regulation of JUN kinase activity
Biological Processnegative regulation of MAPK cascade
Biological Processnegative regulation of protein kinase activity
Biological Processpositive regulation of JNK cascade
Biological Processpositive regulation of JUN kinase activity
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of protein kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dual specificity protein phosphatase 19
  • EC number
  • Alternative names
    • Protein phosphatase SKRP1
    • Stress-activated protein kinase pathway-regulating phosphatase 1

Gene names

    • Name
      Dusp19
    • Synonyms
      Skrp1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K4T5

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for modified residue, chain.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00000948331-220Dual specificity protein phosphatase 19

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain64-205Tyrosine-protein phosphatase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    220
  • Mass (Da)
    24,181
  • Last updated
    2002-10-01 v1
  • Checksum
    5977D907CA7D3EDD
MHSLNQKIKAFSRDNLRKQCTRVTTLTGKKLIETWEDATVHVVETEPSGGGGCGYVQDLTLDLQVGVIKPWLLLGSQDAAHDLELLRKHKVTHILNVAYGVENAFLSEFTYKTISILDVPETNILSYFPECFEFIEQAKLKDGVVLVHCNAGVSRAAAIVIGFLMSSEEATFTTALSLVKEARPSICPNPGFMEQLRTYQVGKESNGGDKVPAEDTTHGL

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q99N12Q99N12_MOUSEDusp19220

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB051896
EMBL· GenBank· DDBJ
BAC01163.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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