Q8K4G5 · ABLM1_MOUSE

  • Protein
    Actin-binding LIM protein 1
  • Gene
    Ablim1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May act as scaffold protein (By similarity).
May play a role in the development of the retina. Has been suggested to play a role in axon guidance

Miscellaneous

Isoform 1 is not necessary for normal axon guidance.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentactin cytoskeleton
Cellular Componentcytoplasm
Cellular Componentlamellipodium
Cellular Componentpostsynaptic density
Cellular Componentstress fiber
Molecular Functionactin binding
Molecular Functionactin filament binding
Molecular Functionmetal ion binding
Biological Processaxon guidance
Biological Processcilium assembly
Biological Processcytoskeleton organization
Biological Processlamellipodium assembly
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processtranscription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Actin-binding LIM protein 1
  • Short names
    abLIM-1
  • Alternative names
    • Actin-binding LIM protein family member 1

Gene names

    • Name
      Ablim1
    • Synonyms
      Ablim, Kiaa0059

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K4G5
  • Secondary accessions
    • Q80U86
    • Q8BIR9
    • Q8K4G3
    • Q8K4G4

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Note: In a striped pattern along the myofibril axis in cardiac myocytes. Associated with the cytoskeleton.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, cross-link.

TypeIDPosition(s)Description
ChainPRO_00000756981-861Actin-binding LIM protein 1
Modified residue216Phosphoserine
Modified residue411Phosphoserine
Modified residue417Phosphotyrosine
Modified residue440Phosphotyrosine
Modified residue466Phosphoserine
Modified residue470Phosphoserine
Modified residue475Phosphoserine
Modified residue477Phosphothreonine
Modified residue479Phosphoserine
Modified residue483Phosphotyrosine
Modified residue496Phosphoserine
Modified residue499Phosphoserine
Modified residue502Phosphoserine
Modified residue582Phosphoserine
Modified residue671Phosphoserine
Cross-link704Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue723Phosphoserine
Modified residue738Phosphoserine
Modified residue760Phosphoserine
Modified residue789Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 is detected in adult retina, where it is highly expressed in the ganglion layer. Detected in rod inner segment. Isoform 2 is highly expressed in adult retina, brain, kidney and heart. Isoform 3 is highly expressed in adult retina, brain, kidney, liver, skeletal muscle, spleen and heart. Detected in embryonic retina, brain, spinal cord, peripheral sensory ganglia and thymus.

Developmental stage

Isoform 1 is detected at low levels starting from 12 dpc and remains constant until birth. After this levels increase strongly and expression remains high in adults. Isoform 2 and isoform 3 are expressed at a constant high level throughout development.

Gene expression databases

Interaction

Subunit

Binds F-actin. Interacts with ABRA (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8K4G5Dlg4 Q621085EBI-2307994, EBI-300895

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias, coiled coil.

TypeIDPosition(s)Description
Domain97-156LIM zinc-binding 1
Domain156-216LIM zinc-binding 2
Domain224-283LIM zinc-binding 3
Domain283-343LIM zinc-binding 4
Region374-414Disordered
Compositional bias377-409Polar residues
Region459-590Disordered
Compositional bias493-521Polar residues
Compositional bias534-550Polar residues
Region634-682Disordered
Compositional bias667-682Basic and acidic residues
Coiled coil673-723
Region713-748Disordered
Compositional bias722-741Polar residues
Domain793-861HP

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete

This entry describes 5 isoforms produced by Alternative splicing.

Q8K4G5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    AbLIM-L
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    861
  • Mass (Da)
    96,805
  • Last updated
    2002-10-01 v1
  • Checksum
    5E045F7CEF1D91EF
MPSLLGLKCLGKLCSSEIGKVPSPERASLRNSHRRLLIEDLSVPETPDPAHRRRGTVIHLVYLYSAGCGPPELRFSSYDPSVAHPQDPHHSSEKPVIHCHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGDYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKEASCSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGSPYCEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEKLRPPNIPRSSSDFFYPKSLIRRTGRSPALQLLSPPCLTNSNKNPRQPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKVKAIYDIERPDLITYEPFYTSGYEDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRSTSQGSINSPVYSRHSYTPTTSRSPQHFHRPELLSPGVHRWSPLRTSSFSSTHSDSRPNPPFRHHFLPHVKGNEPSSGRNSPLPYRPDSRPLTPTYAQAPKHFHVPDQGINIYRKPPIYKQHAALAAQSKASEDIIKFSKFPAAQAPDPNEIPKIETDHWPGPPSLAAVGTDPRRRSSGREEDEEELLRRRQLQEEQLMKLNSGLGQLILKEEMEKESRERASLASRYDSPLHSASHAPSSKTSSLPGYGKNGLHRPVSTDFAQYNSYGDISGGVRDYQTLPDGHMPAVRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILRDVDRTRLERHLAPEVFWEIFGMSIQEFDKLPLWRRNDMKKKAKLF

Q8K4G5-2

  • Name
    2
  • Synonyms
    AbLIM-M
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-81: MPSLLGLKCLGKLCSSEIGKVPSPERASLRNSHRRLLIEDLSVPETPDPAHRRRGTVIHLVYLYSAGCGPPELRFSSYDPS → MVKEK
    • 348-391: Missing
    • 525-564: Missing

Q8K4G5-3

  • Name
    3
  • Synonyms
    AbLIM-S
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q8K4G5-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-81: MPSLLGLKCLGKLCSSEIGKVPSPERASLRNSHRRLLIEDLSVPETPDPAHRRRGTVIHLVYLYSAGCGPPELRFSSYDPS → MVKEK
    • 348-391: Missing
    • 525-564: Missing
    • 616-662: Missing

Q8K4G5-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-77: Missing
    • 78-81: YDPS → MSTR
    • 301-345: DKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHPDCKQSTKTEEK → VTEASRTWSHIDLRWQGRSEELRAWRHSIQSLRHQSAREWFALSA
    • 346-861: Missing

Computationally mapped potential isoform sequences

There are 11 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q9Q7E9Q9Q7_MOUSEAblim1400
E9Q9D1E9Q9D1_MOUSEAblim1426
E9Q9D2E9Q9D2_MOUSEAblim1454
E9Q9C0E9Q9C0_MOUSEAblim1714
E9Q9C1E9Q9C1_MOUSEAblim1744
E9Q9C2E9Q9C2_MOUSEAblim1777
E9Q9C4E9Q9C4_MOUSEAblim1682
E9Q9C7E9Q9C7_MOUSEAblim1668
E9Q030E9Q030_MOUSEAblim1545
F6YHE5F6YHE5_MOUSEAblim1292
E9QK41E9QK41_MOUSEAblim1861

Sequence caution

The sequence BAC65478.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0121051-77in isoform 5
Alternative sequenceVSP_0121041-81in isoform 2 and isoform 4
Alternative sequenceVSP_0121031-316in isoform 3
Alternative sequenceVSP_01210678-81in isoform 5
Alternative sequenceVSP_012107301-345in isoform 5
Alternative sequenceVSP_012109346-861in isoform 5
Alternative sequenceVSP_012108348-391in isoform 2 and isoform 4
Compositional bias377-409Polar residues
Compositional bias493-521Polar residues
Alternative sequenceVSP_012110525-564in isoform 2 and isoform 4
Compositional bias534-550Polar residues
Alternative sequenceVSP_012111616-662in isoform 4
Compositional bias667-682Basic and acidic residues
Compositional bias722-741Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF404774
EMBL· GenBank· DDBJ
AAM73705.1
EMBL· GenBank· DDBJ
mRNA
AF404775
EMBL· GenBank· DDBJ
AAM73706.1
EMBL· GenBank· DDBJ
mRNA
AF404776
EMBL· GenBank· DDBJ
AAM73707.1
EMBL· GenBank· DDBJ
mRNA
AK122196
EMBL· GenBank· DDBJ
BAC65478.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK029371
EMBL· GenBank· DDBJ
BAC26424.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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