Genetic deletion of LRRTM1 2 in vivo in CA1 neurons using Cre recombinase-expressing lentiviruses dramatically impaired long-term potentiation (LTP) an impairment that was rescued by simultaneous expression of LRRTM2 but not LRRTM4.
Using an unbiased transcriptomics approach and targeted mutant mice the authors discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.