Q8K248 · HPDL_MOUSE
- Protein4-hydroxyphenylpyruvate dioxygenase-like protein
- GeneHpdl
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids371 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
Iron-dependent dioxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate (4-HPPA) to 4-hydroxymandelate (4-HMA) in the mitochondria, one of the steps in the biosynthesis of coenzyme Q10 from tyrosine.
Catalytic activity
- 3-(4-hydroxyphenyl)pyruvate + O2 = (S)-4-hydroxymandelate + CO2This reaction proceeds in the forward direction.
Cofactor
Note: Binds 1 Fe cation per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 163 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 258 | Fe cation (UniProtKB | ChEBI) | |||
Binding site | 339 | Fe cation (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Molecular Function | 4-hydroxymandelate synthase activity | |
Molecular Function | 4-hydroxyphenylpyruvate dioxygenase activity | |
Molecular Function | metal ion binding | |
Biological Process | aromatic amino acid metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name4-hydroxyphenylpyruvate dioxygenase-like protein
- EC number
- Short namesHPDL
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8K248
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000271120 | 1-371 | 4-hydroxyphenylpyruvate dioxygenase-like protein | ||
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 7-135 | VOC 1 | |||
Domain | 160-328 | VOC 2 | |||
Sequence similarities
Belongs to the 4HPPD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length371
- Mass (Da)39,909
- Last updated2002-10-01 v1
- MD5 Checksum90686A24C44D335B1C92350668991851
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK043902 EMBL· GenBank· DDBJ | BAC31697.1 EMBL· GenBank· DDBJ | mRNA | ||
AK049217 EMBL· GenBank· DDBJ | BAC33615.1 EMBL· GenBank· DDBJ | mRNA | ||
AK078929 EMBL· GenBank· DDBJ | BAC37467.1 EMBL· GenBank· DDBJ | mRNA | ||
BC034099 EMBL· GenBank· DDBJ | AAH34099.1 EMBL· GenBank· DDBJ | mRNA |