Q8K248 · HPDL_MOUSE

  • Protein
    4-hydroxyphenylpyruvate dioxygenase-like protein
  • Gene
    Hpdl
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Iron-dependent dioxygenase that catalyzes the conversion of 4-hydroxyphenylpyruvate (4-HPPA) to 4-hydroxymandelate (4-HMA) in the mitochondria, one of the steps in the biosynthesis of coenzyme Q10 from tyrosine.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 1 Fe cation per subunit.

Features

Showing features for binding site.

137150100150200250300350
TypeIDPosition(s)Description
Binding site163Fe cation (UniProtKB | ChEBI)
Binding site258Fe cation (UniProtKB | ChEBI)
Binding site339Fe cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrion
Molecular Function4-hydroxymandelate synthase activity
Molecular Function4-hydroxyphenylpyruvate dioxygenase activity
Molecular Functionmetal ion binding
Biological Processaromatic amino acid metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    4-hydroxyphenylpyruvate dioxygenase-like protein
  • EC number
  • Short names
    HPDL
  • Alternative names
    • Glyoxalase domain-containing protein 1

Gene names

    • Name
      Hpdl
    • Synonyms
      Gloxd1

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K248

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002711201-3714-hydroxyphenylpyruvate dioxygenase-like protein

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain7-135VOC 1
Domain160-328VOC 2

Sequence similarities

Belongs to the 4HPPD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    371
  • Mass (Da)
    39,909
  • Last updated
    2002-10-01 v1
  • MD5 Checksum
    90686A24C44D335B1C92350668991851
MTAPARRLCHIAFHVPAGQPLARDLHRVFGFQPLAVREAGGWRQLALRSGDAVFLVNEGTGPQEPLYSLDPHHSVPSATNLCFDVEDVDGAARALAARGCIMPVPPTRVRDAQGTATYTVLSSPAGNLSLTLLQRAGYRGSFLPGFRPLPCTPGPGWVSHVDHLTLACTSGSSPMLMRWFHDCLGFHHLPLSPGEDPEMGLKVAAGSGRGGLRLTALQTPPNNTVPTLVLAESLPGLNSKQDQVEQFLTRHGGPGLQHVGLYTPNIIDASEGMAKAGCRLLTPPEAYYQQPGKEEQILAAGHKPGLLERQGILLDGDKDEFLLQVFTKSLFAEDTFFLELIQRQGATGFGQNNIRALWQSVQEEAARAQGA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK043902
EMBL· GenBank· DDBJ
BAC31697.1
EMBL· GenBank· DDBJ
mRNA
AK049217
EMBL· GenBank· DDBJ
BAC33615.1
EMBL· GenBank· DDBJ
mRNA
AK078929
EMBL· GenBank· DDBJ
BAC37467.1
EMBL· GenBank· DDBJ
mRNA
BC034099
EMBL· GenBank· DDBJ
AAH34099.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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