Q8K1G2 · LBN_MOUSE
- ProteinLimbin
- GeneEvc2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1220 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling (PubMed:21356043, PubMed:24582806).
Plays a critical role in bone formation and skeletal development (PubMed:21356043).
May be involved in early embryonic morphogenesis (PubMed:21356043).
Plays a critical role in bone formation and skeletal development (PubMed:21356043).
May be involved in early embryonic morphogenesis (PubMed:21356043).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | ciliary membrane | |
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | cytoskeleton | |
Cellular Component | nucleus | |
Cellular Component | plasma membrane protein complex | |
Biological Process | smoothened signaling pathway |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLimbin
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8K1G2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Note: The EvC complex localizes at the base of cilia in the EvC zone of primary cilia in a EFCAB7-dependent manner (PubMed:24582806).
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 30-210 | Extracellular | ||||
Sequence: SGPRALPPSFPALGPGSPSRPGPAGPWASSQYSDISREARGPFENGVIFQKCSLVSGQSESQTMHVQLSVNNTRTPTSVNLSNLLVLDEITGLAVKESPGNNTQDGIQTFRKSFLQVGECYSVSYTASLDPTALGTGESLDLPARLIFQSPSQNRTQLKAPFTITVEEKIMVLPNHGLHAA | ||||||
Transmembrane | 211-231 | Helical | ||||
Sequence: GFIAAFLISLLLTVAALFFLA | ||||||
Topological domain | 232-1220 | Cytoplasmic | ||||
Sequence: RGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQADADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQREMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQSTAMTQELLKRSAPWLFLQQILEEHSRESAARTTQLEAEERERGQELVQGVRQRLQQDALEAYTEEQAELRHWEHLVFMKLCCAAISLSEEDLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLSVYTALLSIQDLLLGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREEWQNGAVLEDSLESIEADTMASLCSQGLRLVSYLSRMTMVPGSTLLRLLSVVLPAASQPQLLALLDAVSEKHSDHTAENESSGEQAQAEQSKRRKHQVWWKVLDSRFRADLVSQGLERMLWARQKKERILKKIYVPVQERVMFPGKGSWPHLSLEPIGELAPIPITGADAMDILNTGEKIFVFRSPREPEISLRVPPRRKKNFLNAKKANRALGLD |
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 1185-1188 | Inhibits interaction with EFCAB7. | ||||
Sequence: FVFR → AAAA |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 63 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-29 | |||||
Sequence: MGATGPTGAGGRATWVLAGNILAAALVLG | ||||||
Chain | PRO_0000084364 | 30-1220 | Limbin | |||
Sequence: SGPRALPPSFPALGPGSPSRPGPAGPWASSQYSDISREARGPFENGVIFQKCSLVSGQSESQTMHVQLSVNNTRTPTSVNLSNLLVLDEITGLAVKESPGNNTQDGIQTFRKSFLQVGECYSVSYTASLDPTALGTGESLDLPARLIFQSPSQNRTQLKAPFTITVEEKIMVLPNHGLHAAGFIAAFLISLLLTVAALFFLARGRCLQGGMLSRCRIQHPENKLEPSPFTSANGVSQDLSLNDQVVAILTSEEPGSMLQALEELEIATLNQADADLEACRNQISKDIIALLMKNLVSGGHLSPQTERKMAAAFKKQFLLLENEIQEEYERKMLALTAECDLEMRKKTENQYQREMVAMEEAEEVLKRVSERSAAECSSLLRTLHGLEQEDMQRSLTLDQAEDFAQAHRQLAVFQRNELHSIVYTQIQSAVSKGELRPEVAKMMLQDYSKTQESVEELMDFFQATKRYHLSKRFGHREYLVQRLQAMETRVQGLLNTAATQLTSLIHKHERAGYLDEDQMETLLERAQTETFSIKQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALDDLRVLTVSLSEKATEELRRLQSTAMTQELLKRSAPWLFLQQILEEHSRESAARTTQLEAEERERGQELVQGVRQRLQQDALEAYTEEQAELRHWEHLVFMKLCCAAISLSEEDLLRVRQEAQGCFSQLDRSLALPRVRARVLQQQAQMAWREAEFRKLDQALAAPELQSKARKLRSKGRGKADLLKKNLEDKIRLFEERAPVELADQVRGELLQERVQRLEAQEAHFAESLVALQFQKVARAAETLSVYTALLSIQDLLLGELSESETLTKSACVQILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREEWQNGAVLEDSLESIEADTMASLCSQGLRLVSYLSRMTMVPGSTLLRLLSVVLPAASQPQLLALLDAVSEKHSDHTAENESSGEQAQAEQSKRRKHQVWWKVLDSRFRADLVSQGLERMLWARQKKERILKKIYVPVQERVMFPGKGSWPHLSLEPIGELAPIPITGADAMDILNTGEKIFVFRSPREPEISLRVPPRRKKNFLNAKKANRALGLD | ||||||
Glycosylation | 100 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 109 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 130 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in long and cranial bones, kidney and heart. Strongly expressed in proliferating chondrocytes, osteoblasts and osteoclasts.
Developmental stage
Found in the embryo at day 7 dpc, 11 dpc, 15 dpc, and 17 dpc. At the limb bud formation stage 11 dpc, it is expressed in fore- and hindlimb buds, branchial arches, and facial primordia.
Gene expression databases
Interaction
Subunit
Component of the EvC complex composed of EFCAB7, IQCE, EVC2 and EVC; built from two subcomplexes, EVC2:EVC and EFCAB7:IQCE (PubMed:24582806).
Interacts with EVC (PubMed:21356043, PubMed:24582806).
Interacts (via N-terminal end) with EFCAB7 (PubMed:24582806).
Interacts (via N-terminal end) with IQCE (PubMed:24582806).
Interacts with EVC (PubMed:21356043, PubMed:24582806).
Interacts (via N-terminal end) with EFCAB7 (PubMed:24582806).
Interacts (via N-terminal end) with IQCE (PubMed:24582806).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 38-59 | Disordered | ||||
Sequence: SFPALGPGSPSRPGPAGPWASS | ||||||
Coiled coil | 355-404 | |||||
Sequence: EEYERKMLALTAECDLEMRKKTENQYQREMVAMEEAEEVLKRVSERSAAE | ||||||
Coiled coil | 563-644 | |||||
Sequence: KQKLDNDLKQEKKRLHQRLITRRRRELLQKHKEQQKEQVSLGEASSTAEDAVQYLHQWRSVMAEHTAALEELQERLDQAALD | ||||||
Coiled coil | 854-875 | |||||
Sequence: GELLQERVQRLEAQEAHFAESL | ||||||
Coiled coil | 920-1005 | |||||
Sequence: QILESHRPELQELQELERKLEDQLVQQEEAEQQRVLESWQRWAADGPGLSEPEEMDPERQVSAILRQALNKGQKLLEQHQQRVREE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length1,220
- Mass (Da)137,639
- Last updated2002-10-01 v1
- ChecksumE67671714A866B1D
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB083066 EMBL· GenBank· DDBJ | BAC06589.1 EMBL· GenBank· DDBJ | mRNA | ||
BC037473 EMBL· GenBank· DDBJ | AAH37473.1 EMBL· GenBank· DDBJ | mRNA | ||
BC064473 EMBL· GenBank· DDBJ | AAH64473.1 EMBL· GenBank· DDBJ | mRNA | ||
AK044977 EMBL· GenBank· DDBJ | BAC32167.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |