Q8K1E3 · DLK2_MOUSE

  • Protein
    Protein delta homolog 2
  • Gene
    Dlk2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Regulates adipogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Molecular Functioncalcium ion binding
Molecular Functionidentical protein binding
Molecular FunctionNotch binding
Biological Processnegative regulation of Notch signaling pathway
Biological Processregulation of fat cell differentiation

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein delta homolog 2
  • Short names
    DLK-2
  • Alternative names
    • Endothelial cell-specific protein S-1
    • Epidermal growth factor-like protein 9 (EGF-like protein 9)

Gene names

    • Name
      Dlk2
    • Synonyms
      Egfl9

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K1E3
  • Secondary accessions
    • B5B9L4
    • Q0IIP7
    • Q148N7
    • Q9QYP3

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain27-305Extracellular
Transmembrane306-326Helical
Topological domain327-382Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-26
ChainPRO_000039662027-382Protein delta homolog 2
Disulfide bond29↔40
Disulfide bond33↔46
Disulfide bond48↔57
Disulfide bond66↔71
Disulfide bond79↔88
Disulfide bond95↔107
Disulfide bond101↔117
Disulfide bond119↔128
Disulfide bond135↔148
Disulfide bond142↔160
Glycosylation157N-linked (GlcNAc...) asparagine
Disulfide bond162↔171
Disulfide bond178↔189
Disulfide bond183↔198
Disulfide bond200↔209
Disulfide bond216↔227
Disulfide bond221↔236
Disulfide bond238↔247

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in a number of tissues including lung, brain, adrenal gland, testis, adult liver, placenta, ovary and thymus. Not detected in fetal liver or in adult spleen, muscle and heart.

Developmental stage

Absent from liver after birth, but increases around postnatal day 16.

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-58EGF-like 1
Domain62-89EGF-like 2
Domain91-129EGF-like 3
Domain131-172EGF-like 4
Domain174-210EGF-like 5; calcium-binding
Domain212-248EGF-like 6; calcium-binding

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative splicing.

Q8K1E3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    382
  • Mass (Da)
    40,404
  • Last updated
    2011-06-28 v3
  • Checksum
    F2C82AD649CA0B3C
MPSGCRCLNLVCLLCILGATSQPARADDCSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCICHSGWAGKFCDKDEHICTSQSPCQNGGQCVYDGGGEYHCVCLPGFHGRGCERKAGPCEQAGFPCRNGGQCQDNQGFALNFTCRCLAGFMGAHCEVNVDDCLMRPCANGATCIDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPAPEPASVGTPQMPTSAVVVPATGPAPHSAGAGLLRISVKEVVRRQESGLGESSLVALVVFGSLTAALVLATVLLTLRAWRRGICPTGPCCYPAPHYAPARQDQECQVSMLPAGFPLSPDLPPEPGKTTAL

Q8K1E3-3

  • Name
    1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MKITMRVSVPLSPRQAASQPVPSHRCLHVWPFIRPSLLRPELTM

Q8K1E3-4

  • Name
    3
  • Note
    Splice sites are non-canonical.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MKITMRPGDASPPSRRCLHVWPFIRPSLLRPELTM

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9Q0Y2E9Q0Y2_MOUSEDlk2152
A0A087WSS3A0A087WSS3_MOUSEDlk2108

Sequence caution

The sequence BAA88686.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0395831in isoform 1
Alternative sequenceVSP_0395841in isoform 3
Sequence conflict236in Ref. 4; AAI18058
Sequence conflict295-311in Ref. 6; BAA88686

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM180474
EMBL· GenBank· DDBJ
CAQ86598.1
EMBL· GenBank· DDBJ
mRNA
CT009572
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466559
EMBL· GenBank· DDBJ
EDL23496.1
EMBL· GenBank· DDBJ
Genomic DNA
BC019431
EMBL· GenBank· DDBJ
-mRNA No translation available.
BC118057
EMBL· GenBank· DDBJ
AAI18058.1
EMBL· GenBank· DDBJ
mRNA
BC122518
EMBL· GenBank· DDBJ
AAI22519.1
EMBL· GenBank· DDBJ
mRNA
BY271273
EMBL· GenBank· DDBJ
-mRNA No translation available.
AB011019
EMBL· GenBank· DDBJ
BAA88686.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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