Q8K0F1 · TBC23_MOUSE

  • Protein
    TBC1 domain family member 23
  • Gene
    Tbc1d23
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197).
Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity).
Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707).
May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasmic vesicle
Cellular Componentcytosol
Cellular Componenttrans-Golgi network
Biological Processbrain development
Biological Processembryonic brain development
Biological Processneuron projection development
Biological Processpositive regulation of interleukin-6 production
Biological Processregulation of inflammatory response
Biological Processregulation of tumor necrosis factor production
Biological Processretrograde transport, endosome to Golgi
Biological Processvesicle tethering to Golgi
Biological Processvesicle-mediated transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    TBC1 domain family member 23

Gene names

    • Name
      Tbc1d23

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • NOD
    • Czech II
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K0F1
  • Secondary accessions
    • Q3TAW9
    • Q8VE48

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic vesicle
Note: Localization to the trans-Golgi (TGN) is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (By similarity).
Recruited on AP-1-derived vesicles by WDR11 complex (By similarity).

Keywords

Phenotypes & Variants

Disruption phenotype

Mutant mice exhibit increased inflammatory cytokine production and recruit more inflammatory cells to the peritoneum, when challenged with different pathogen-associated molecular patterns (PAMPs), including LPS.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis50Fails to inhibit LPS-induced cytokine production.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00002874981-684TBC1 domain family member 23
Modified residue300Phosphoserine
Modified residue469Phosphoserine
Modified residue474Phosphoserine
Modified residue507Phosphoserine
Modified residue514Phosphothreonine
Modified residue556Phosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Directly interacts with GOLGA1 and GOLGA4 (PubMed:29084197).
Interacts with FAM91A1, C17ORF75 and WDR11; the interaction recruits TBC1D23 to AP-1-derived vesicles (PubMed:29084197).
Directly interacts with WASHC1 and WASHC2/FAM21 (PubMed:29084197).
Interacts with FKBP15 (PubMed:29084197).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain44-225Rab-GAP TBC
Domain334-446Rhodanese
Region514-558May mediate the interaction with C17orf75, FAM91A1 and WDR11
Region514-684May mediate the interaction with WASHC1
Region559-684May mediate the interaction with FKBP15 and WASHC2; required for endosome to Golgi trafficking

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8K0F1-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    684
  • Mass (Da)
    76,426
  • Last updated
    2002-10-01 v1
  • Checksum
    B1DE9548FFB0A7FE
MAEGEELLPLSTSGGDSWEKDLEEALEAGGCDLETLRNIIQGRPLPAELRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIEQLSVPEEKAAELLLDIESVITFYCKSRSVKYSTSLSWIHLLKPLICLQLPRSDLYNCFYAVMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFAHYCSTEVTQAIWDGYLQQADPFFIYFLMLIILVNTKEVILAQESDSKEEVIRFLESTPASLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDEADLSQALCLAVSVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLATAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVEGPESGYGHWIASTSGSRGSISSVDGESCNGSNDRGMKSLVSKMTVALKTKSVTVREKVISFIENSSTPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATRAIKQQIMKVLDALES

Q8K0F1-2

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A2I3BPS3A0A2I3BPS3_MOUSETbc1d2397
A0A2I3BRD1A0A2I3BRD1_MOUSETbc1d23699

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_025520201-203in isoform 2
Alternative sequenceVSP_025521204-684in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK155142
EMBL· GenBank· DDBJ
BAE33073.1
EMBL· GenBank· DDBJ
mRNA
AK171591
EMBL· GenBank· DDBJ
BAE42547.1
EMBL· GenBank· DDBJ
mRNA
BC019762
EMBL· GenBank· DDBJ
AAH19762.1
EMBL· GenBank· DDBJ
mRNA
BC031706
EMBL· GenBank· DDBJ
AAH31706.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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