Q8K0F1 · TBC23_MOUSE
- ProteinTBC1 domain family member 23
- GeneTbc1d23
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids684 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197).
Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity).
Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707).
May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129).
Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity).
Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707).
May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic vesicle | |
Cellular Component | cytosol | |
Cellular Component | trans-Golgi network | |
Biological Process | brain development | |
Biological Process | embryonic brain development | |
Biological Process | neuron projection development | |
Biological Process | positive regulation of interleukin-6 production | |
Biological Process | regulation of inflammatory response | |
Biological Process | regulation of tumor necrosis factor production | |
Biological Process | retrograde transport, endosome to Golgi | |
Biological Process | vesicle tethering to Golgi | |
Biological Process | vesicle-mediated transport |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameTBC1 domain family member 23
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8K0F1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localization to the trans-Golgi (TGN) is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (By similarity).
Recruited on AP-1-derived vesicles by WDR11 complex (By similarity).
Recruited on AP-1-derived vesicles by WDR11 complex (By similarity).
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mutant mice exhibit increased inflammatory cytokine production and recruit more inflammatory cells to the peritoneum, when challenged with different pathogen-associated molecular patterns (PAMPs), including LPS.
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 50 | Fails to inhibit LPS-induced cytokine production. | ||||
Sequence: R → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 25 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000287498 | 1-684 | TBC1 domain family member 23 | |||
Sequence: MAEGEELLPLSTSGGDSWEKDLEEALEAGGCDLETLRNIIQGRPLPAELRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIEQLSVPEEKAAELLLDIESVITFYCKSRSVKYSTSLSWIHLLKPLICLQLPRSDLYNCFYAVMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFAHYCSTEVTQAIWDGYLQQADPFFIYFLMLIILVNTKEVILAQESDSKEEVIRFLESTPASLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDEADLSQALCLAVSVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLATAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVEGPESGYGHWIASTSGSRGSISSVDGESCNGSNDRGMKSLVSKMTVALKTKSVTVREKVISFIENSSTPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATRAIKQQIMKVLDALES | ||||||
Modified residue | 300 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 469 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 474 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 507 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 514 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 556 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Directly interacts with GOLGA1 and GOLGA4 (PubMed:29084197).
Interacts with FAM91A1, C17ORF75 and WDR11; the interaction recruits TBC1D23 to AP-1-derived vesicles (PubMed:29084197).
Directly interacts with WASHC1 and WASHC2/FAM21 (PubMed:29084197).
Interacts with FKBP15 (PubMed:29084197).
Interacts with FAM91A1, C17ORF75 and WDR11; the interaction recruits TBC1D23 to AP-1-derived vesicles (PubMed:29084197).
Directly interacts with WASHC1 and WASHC2/FAM21 (PubMed:29084197).
Interacts with FKBP15 (PubMed:29084197).
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 44-225 | Rab-GAP TBC | ||||
Sequence: PLPAELRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIEQLSVPEEKAAELLLDIESVITFYCKSRSVKYSTSLSWIHLLKPLICLQLPRSDLYNCFYAVMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFAHYCSTEVTQAIWDGYLQQA | ||||||
Domain | 334-446 | Rhodanese | ||||
Sequence: EGVRFFVVDCRPAEQYNAGHLATAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINV | ||||||
Region | 514-558 | May mediate the interaction with C17orf75, FAM91A1 and WDR11 | ||||
Sequence: TPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDD | ||||||
Region | 514-684 | May mediate the interaction with WASHC1 | ||||
Sequence: TPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATRAIKQQIMKVLDALES | ||||||
Region | 559-684 | May mediate the interaction with FKBP15 and WASHC2; required for endosome to Golgi trafficking | ||||
Sequence: DRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATRAIKQQIMKVLDALES |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8K0F1-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length684
- Mass (Da)76,426
- Last updated2002-10-01 v1
- ChecksumB1DE9548FFB0A7FE
Q8K0F1-2
- Name2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2I3BPS3 | A0A2I3BPS3_MOUSE | Tbc1d23 | 97 | ||
A0A2I3BRD1 | A0A2I3BRD1_MOUSE | Tbc1d23 | 699 |
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK155142 EMBL· GenBank· DDBJ | BAE33073.1 EMBL· GenBank· DDBJ | mRNA | ||
AK171591 EMBL· GenBank· DDBJ | BAE42547.1 EMBL· GenBank· DDBJ | mRNA | ||
BC019762 EMBL· GenBank· DDBJ | AAH19762.1 EMBL· GenBank· DDBJ | mRNA | ||
BC031706 EMBL· GenBank· DDBJ | AAH31706.1 EMBL· GenBank· DDBJ | mRNA |