Q8K078 · SO4A1_MOUSE

  • Protein
    Solute carrier organic anion transporter family member 4A1
  • Gene
    Slco4a1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity).
May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity).
The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable)

Catalytic activity

  • 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)
    This reaction proceeds in the forward direction.
  • L-thyroxine(out) + L-glutamate(in) = L-thyroxine(in) + L-glutamate(out)
    This reaction proceeds in the forward direction.
  • estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)
    This reaction proceeds in the forward direction.
  • taurocholate(out) + L-glutamate(in) = taurocholate(in) + L-glutamate(out)
    This reaction proceeds in the forward direction.
  • 3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)
    This reaction proceeds in the forward direction.
  • L-thyroxine(out) = L-thyroxine(in)
    This reaction proceeds in the forward direction.
  • 3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)
    This reaction proceeds in the forward direction.
  • estrone 3-sulfate(out) = estrone 3-sulfate(in)
    This reaction proceeds in the forward direction.
  • 17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)
    This reaction proceeds in the forward direction.
  • taurocholate(out) = taurocholate(in)
    This reaction proceeds in the forward direction.
  • prostaglandin E2(out) = prostaglandin E2(in)
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionorganic anion transmembrane transporter activity
Molecular Functionprostaglandin transmembrane transporter activity
Biological Processmonoatomic ion transport
Biological Processorganic anion transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier organic anion transporter family member 4A1
  • Alternative names
    • Organic anion-transporting polypeptide E (OATP-E)
    • Sodium-independent organic anion transporter E
    • Solute carrier family 21 member 12

Gene names

    • Name
      Slco4a1
    • Synonyms
      Oatp4a1, Oatpe, Slc21a12

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8K078
  • Secondary accessions
    • Q8BZT4

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-102Cytoplasmic
Transmembrane103-123Helical; Name=1
Topological domain124-142Extracellular
Transmembrane143-163Helical; Name=2
Topological domain164-169Cytoplasmic
Transmembrane170-194Helical; Name=3
Topological domain195-224Extracellular
Transmembrane225-255Helical; Name=4
Topological domain256-274Cytoplasmic
Transmembrane275-295Helical; Name=5
Topological domain296-309Extracellular
Transmembrane310-334Helical; Name=6
Topological domain335-380Cytoplasmic
Transmembrane381-402Helical; Name=7
Topological domain403-422Extracellular
Transmembrane423-446Helical; Name=8
Topological domain447-450Cytoplasmic
Transmembrane451-473Helical; Name=9
Topological domain474-582Extracellular
Transmembrane583-605Helical; Name=10
Topological domain606-614Cytoplasmic
Transmembrane615-640Helical; Name=11
Topological domain641-673Extracellular
Transmembrane674-691Helical; Name=12
Topological domain692-723Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, glycosylation, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_00001910681-723Solute carrier organic anion transporter family member 4A1
Modified residue39Phosphoserine
Modified residue42Phosphoserine
Modified residue45Phosphoserine
Glycosylation212N-linked (GlcNAc...) asparagine
Disulfide bond506↔536
Disulfide bond521↔555
Glycosylation566N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region23-64Disordered
Domain500-557Kazal-like
Region700-723Disordered

Domain

A conserved histidine residue in the third TMD (His-190) may play an essential role in the pH sensitivity of SLCO4A1/OATP4A1-mediated substrate transport.

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8K078-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    723
  • Mass (Da)
    77,669
  • Last updated
    2003-01-10 v2
  • Checksum
    0856B45F02C4EBAC
MPQHAMGDTHFLSLPKHLFTSTSSATDSGCDTPPSSRASPASLRSAHGTLGSSSQPLFEPQAEKRSSQTAREVQYVSSGPQNSLCGWQAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAGRYEVEMDEGLGTGTCLTNQSHVECKDSASGLSNYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLRCVSDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV

Q8K078-2

Sequence caution

The sequence AAH33602.1 differs from that shown. Reason: Erroneous initiation

Features

Showing features for sequence conflict, alternative sequence.

Type
IDPosition(s)Description
Sequence conflict28in Ref. 1; BAC28379
Alternative sequenceVSP_006157629-632in isoform 2
Alternative sequenceVSP_006158633-723in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK033598
EMBL· GenBank· DDBJ
BAC28379.1
EMBL· GenBank· DDBJ
mRNA
BC030719
EMBL· GenBank· DDBJ
AAH30719.1
EMBL· GenBank· DDBJ
mRNA
BC030720
EMBL· GenBank· DDBJ
AAH30720.1
EMBL· GenBank· DDBJ
mRNA
BC033602
EMBL· GenBank· DDBJ
AAH33602.1
EMBL· GenBank· DDBJ
mRNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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