Q8K078 · SO4A1_MOUSE
- ProteinSolute carrier organic anion transporter family member 4A1
- GeneSlco4a1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids723 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity).
May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity).
The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable)
May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity).
The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable)
Catalytic activity
- 3,3',5-triiodo-L-thyronine(out) + L-glutamate(in) = 3,3',5-triiodo-L-thyronine(in) + L-glutamate(out)This reaction proceeds in the forward direction.
- L-thyroxine(out) + L-glutamate(in) = L-thyroxine(in) + L-glutamate(out)This reaction proceeds in the forward direction.
- estrone 3-sulfate(out) + L-glutamate(in) = estrone 3-sulfate(in) + L-glutamate(out)This reaction proceeds in the forward direction.
- taurocholate(out) + L-glutamate(in) = taurocholate(in) + L-glutamate(out)This reaction proceeds in the forward direction.
- 3,3',5-triiodo-L-thyronine(out) = 3,3',5-triiodo-L-thyronine(in)This reaction proceeds in the forward direction.
- L-thyroxine(out) = L-thyroxine(in)This reaction proceeds in the forward direction.
- 3,3',5'-triiodo-L-thyronine(out) = 3,3',5'-triiodo-L-thyronine(in)This reaction proceeds in the forward direction.
- estrone 3-sulfate(out) = estrone 3-sulfate(in)This reaction proceeds in the forward direction.
- 17beta-estradiol 17-O-(beta-D-glucuronate)(out) = 17beta-estradiol 17-O-(beta-D-glucuronate)(in)This reaction proceeds in the forward direction.
- taurocholate(out) = taurocholate(in)This reaction proceeds in the forward direction.
- prostaglandin E2(out) = prostaglandin E2(in)This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | organic anion transmembrane transporter activity | |
Molecular Function | prostaglandin transmembrane transporter activity | |
Biological Process | monoatomic ion transport | |
Biological Process | organic anion transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSolute carrier organic anion transporter family member 4A1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8K078
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 1-102 | Cytoplasmic | |||
Transmembrane | 103-123 | Helical; Name=1 | |||
Topological domain | 124-142 | Extracellular | |||
Transmembrane | 143-163 | Helical; Name=2 | |||
Topological domain | 164-169 | Cytoplasmic | |||
Transmembrane | 170-194 | Helical; Name=3 | |||
Topological domain | 195-224 | Extracellular | |||
Transmembrane | 225-255 | Helical; Name=4 | |||
Topological domain | 256-274 | Cytoplasmic | |||
Transmembrane | 275-295 | Helical; Name=5 | |||
Topological domain | 296-309 | Extracellular | |||
Transmembrane | 310-334 | Helical; Name=6 | |||
Topological domain | 335-380 | Cytoplasmic | |||
Transmembrane | 381-402 | Helical; Name=7 | |||
Topological domain | 403-422 | Extracellular | |||
Transmembrane | 423-446 | Helical; Name=8 | |||
Topological domain | 447-450 | Cytoplasmic | |||
Transmembrane | 451-473 | Helical; Name=9 | |||
Topological domain | 474-582 | Extracellular | |||
Transmembrane | 583-605 | Helical; Name=10 | |||
Topological domain | 606-614 | Cytoplasmic | |||
Transmembrane | 615-640 | Helical; Name=11 | |||
Topological domain | 641-673 | Extracellular | |||
Transmembrane | 674-691 | Helical; Name=12 | |||
Topological domain | 692-723 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000191068 | 1-723 | Solute carrier organic anion transporter family member 4A1 | ||
Modified residue | 39 | Phosphoserine | |||
Modified residue | 42 | Phosphoserine | |||
Modified residue | 45 | Phosphoserine | |||
Glycosylation | 212 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 506↔536 | ||||
Disulfide bond | 521↔555 | ||||
Glycosylation | 566 | N-linked (GlcNAc...) asparagine | |||
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 23-64 | Disordered | |||
Domain | 500-557 | Kazal-like | |||
Region | 700-723 | Disordered | |||
Domain
A conserved histidine residue in the third TMD (His-190) may play an essential role in the pH sensitivity of SLCO4A1/OATP4A1-mediated substrate transport.
Sequence similarities
Belongs to the organo anion transporter (TC 2.A.60) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8K078-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length723
- Mass (Da)77,669
- Last updated2003-01-10 v2
- Checksum0856B45F02C4EBAC
Q8K078-2
- Name2
Sequence caution
Features
Showing features for sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 28 | in Ref. 1; BAC28379 | |||
Alternative sequence | VSP_006157 | 629-632 | in isoform 2 | ||
Alternative sequence | VSP_006158 | 633-723 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK033598 EMBL· GenBank· DDBJ | BAC28379.1 EMBL· GenBank· DDBJ | mRNA | ||
BC030719 EMBL· GenBank· DDBJ | AAH30719.1 EMBL· GenBank· DDBJ | mRNA | ||
BC030720 EMBL· GenBank· DDBJ | AAH30720.1 EMBL· GenBank· DDBJ | mRNA | ||
BC033602 EMBL· GenBank· DDBJ | AAH33602.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |