Q8JZV7 · NAGA_MOUSE

  • Protein
    N-acetylglucosamine-6-phosphate deacetylase
  • Gene
    Amdhd2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Binds 1 divalent metal cation per subunit.

Pathway

Amino-sugar metabolism; N-acetylneuraminate degradation.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site143a divalent metal cation (UniProtKB | ChEBI)
Binding site154-155substrate
Binding site211a divalent metal cation (UniProtKB | ChEBI)
Binding site232a divalent metal cation (UniProtKB | ChEBI)
Binding site235-236substrate
Binding site243substrate
Binding site269-272substrate
Active site294Proton donor/acceptor
Binding site328-330substrate

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular FunctionN-acetylgalactosamine-6-phosphate deacetylase activity
Molecular FunctionN-acetylglucosamine-6-phosphate deacetylase activity
Biological ProcessN-acetylglucosamine catabolic process
Biological ProcessN-acetylneuraminate catabolic process
Biological Processnegative regulation of UDP-N-acetylglucosamine biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylglucosamine-6-phosphate deacetylase
  • EC number
  • Short names
    GlcNAc 6-P deacetylase
  • Alternative names
    • Amidohydrolase domain-containing protein 2

Gene names

    • Name
      Amdhd2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8JZV7
  • Secondary accessions
    • Q8BK10

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003157771-409N-acetylglucosamine-6-phosphate deacetylase

Proteomic databases

2D gel databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    43,501
  • Last updated
    2002-10-01 v1
  • Checksum
    914930464779CAC7
MRSGQCAAGAPVLQFTNCRILRGGTLLREDLWVRGGRILDPEKLFFEERRVADEQRDCGGRILAPGFIDVQINGGFGVDFSKATEDVGSGVALVARRLLSHGVTSFCPTLVTSPPEVYHKVLPQIPVKSGGPHGAGVLGVHLEGPFISREKRGAHPEAYLRSFEANAFHDVLATYGPLDNVCIVTLAPELDRSHEVIQALTAQGIRVSLGHSVADLRAAEVAVQSGATFITHLFNAMLPFHHRDPGIVGLLTSDQLPPGHCIFYGMIADGIHTNPAALRIAHRAHPQGLVLVTDAVPALGLGNGRHTLGQQEVEVDGLIAYIAGTKTLGGSIAPMDVCVRHFLQATGCSVESALEAASLHPAQMLGLEKTKGSLDFGADADFVVLDDTLHVQATYISGELVWQAEEAGP

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
F7CUP3F7CUP3_MOUSEAmdhd2446
F6UP77F6UP77_MOUSEAmdhd2453

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict354in Ref. 1; BAC36877

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK077584
EMBL· GenBank· DDBJ
BAC36877.1
EMBL· GenBank· DDBJ
mRNA
AK090009
EMBL· GenBank· DDBJ
BAC41042.1
EMBL· GenBank· DDBJ
mRNA
AK159860
EMBL· GenBank· DDBJ
BAE35434.1
EMBL· GenBank· DDBJ
mRNA
AK168432
EMBL· GenBank· DDBJ
BAE40339.1
EMBL· GenBank· DDBJ
mRNA
BC037005
EMBL· GenBank· DDBJ
AAH37005.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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