Q8JZV7 · NAGA_MOUSE
- ProteinN-acetylglucosamine-6-phosphate deacetylase
- GeneAmdhd2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids409 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Hydrolyzes the N-glycolyl group from N-glycolylglucosamine 6-phosphate (GlcNGc-6-P) in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.
Catalytic activity
- H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate
Cofactor
Note: Binds 1 divalent metal cation per subunit.
Pathway
Amino-sugar metabolism; N-acetylneuraminate degradation.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 143 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 154-155 | substrate | ||||
Sequence: AH | ||||||
Binding site | 211 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 232 | a divalent metal cation (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 235-236 | substrate | ||||
Sequence: NA | ||||||
Binding site | 243 | substrate | ||||
Sequence: R | ||||||
Binding site | 269-272 | substrate | ||||
Sequence: DGIH | ||||||
Active site | 294 | Proton donor/acceptor | ||||
Sequence: D | ||||||
Binding site | 328-330 | substrate | ||||
Sequence: LGG |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | metal ion binding | |
Molecular Function | N-acetylgalactosamine-6-phosphate deacetylase activity | |
Molecular Function | N-acetylglucosamine-6-phosphate deacetylase activity | |
Biological Process | N-acetylglucosamine catabolic process | |
Biological Process | N-acetylneuraminate catabolic process | |
Biological Process | negative regulation of UDP-N-acetylglucosamine biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameN-acetylglucosamine-6-phosphate deacetylase
- EC number
- Short namesGlcNAc 6-P deacetylase
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8JZV7
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000315777 | 1-409 | N-acetylglucosamine-6-phosphate deacetylase | |||
Sequence: MRSGQCAAGAPVLQFTNCRILRGGTLLREDLWVRGGRILDPEKLFFEERRVADEQRDCGGRILAPGFIDVQINGGFGVDFSKATEDVGSGVALVARRLLSHGVTSFCPTLVTSPPEVYHKVLPQIPVKSGGPHGAGVLGVHLEGPFISREKRGAHPEAYLRSFEANAFHDVLATYGPLDNVCIVTLAPELDRSHEVIQALTAQGIRVSLGHSVADLRAAEVAVQSGATFITHLFNAMLPFHHRDPGIVGLLTSDQLPPGHCIFYGMIADGIHTNPAALRIAHRAHPQGLVLVTDAVPALGLGNGRHTLGQQEVEVDGLIAYIAGTKTLGGSIAPMDVCVRHFLQATGCSVESALEAASLHPAQMLGLEKTKGSLDFGADADFVVLDDTLHVQATYISGELVWQAEEAGP |
Proteomic databases
2D gel databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length409
- Mass (Da)43,501
- Last updated2002-10-01 v1
- Checksum914930464779CAC7
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 354 | in Ref. 1; BAC36877 | ||||
Sequence: L → M |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK077584 EMBL· GenBank· DDBJ | BAC36877.1 EMBL· GenBank· DDBJ | mRNA | ||
AK090009 EMBL· GenBank· DDBJ | BAC41042.1 EMBL· GenBank· DDBJ | mRNA | ||
AK159860 EMBL· GenBank· DDBJ | BAE35434.1 EMBL· GenBank· DDBJ | mRNA | ||
AK168432 EMBL· GenBank· DDBJ | BAE40339.1 EMBL· GenBank· DDBJ | mRNA | ||
BC037005 EMBL· GenBank· DDBJ | AAH37005.1 EMBL· GenBank· DDBJ | mRNA |