Q8JZS7 · HMGC2_MOUSE

  • Protein
    3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
  • Gene
    Hmgcll1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Non-mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues.

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Pathway

Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site56substrate
Binding site57a divalent metal cation (UniProtKB | ChEBI)
Binding site248a divalent metal cation (UniProtKB | ChEBI)
Binding site250a divalent metal cation (UniProtKB | ChEBI)
Active site281
Binding site290a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Cellular Componentmembrane
Cellular Componentperinuclear region of cytoplasm
Molecular Functionhydroxymethylglutaryl-CoA lyase activity
Molecular Functionmetal ion binding
Biological Processketone body biosynthetic process
Biological ProcessL-leucine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic
  • EC number
  • Alternative names
    • 3-hydroxy-3-methylglutaryl-CoA lyase-like protein 1

Gene names

    • Name
      Hmgcll1

Organism names

  • Taxonomic identifier
  • Strain
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8JZS7

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, lipidation, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Lipidation2N-myristoyl glycine
ChainPRO_00003346702-3433-hydroxy-3-methylglutaryl-CoA lyase, cytoplasmic

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain48-315Pyruvate carboxyltransferase

Sequence similarities

Belongs to the HMG-CoA lyase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    343
  • Mass (Da)
    36,650
  • Last updated
    2002-10-01 v1
  • Checksum
    1C9400381FB979DC
MGNLPSAAKHCLNYQQLLREHLWSGDSVAGALDAAQEASQLPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSRWVPQMADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNINCSIEESMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVAQASFNARLE

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
V9GXD2V9GXD2_MOUSEHmgcll1177
V9GWZ9V9GWZ9_MOUSEHmgcll1240
D3YVU9D3YVU9_MOUSEHmgcll1311

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK141622
EMBL· GenBank· DDBJ
BAE24772.1
EMBL· GenBank· DDBJ
mRNA
BC037381
EMBL· GenBank· DDBJ
AAH37381.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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