Q8JZQ0 · CSF1_RAT

  • Protein
    Macrophage colony-stimulating factor 1
  • Gene
    Csf1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of pro-inflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCSF1-CSF1R complex
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Molecular Functioncytokine activity
Molecular Functiongrowth factor activity
Molecular Functionidentical protein binding
Molecular Functionmacrophage colony-stimulating factor receptor binding
Molecular Functionprotein homodimerization activity
Biological Processbranching involved in mammary gland duct morphogenesis
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processcellular response to parathyroid hormone stimulus
Biological Processdevelopmental process involved in reproduction
Biological Processhomeostasis of number of cells within a tissue
Biological Processinflammatory response
Biological Processinnate immune response
Biological Processmacrophage colony-stimulating factor signaling pathway
Biological Processmacrophage differentiation
Biological Processmacrophage homeostasis
Biological Processmammary duct terminal end bud growth
Biological Processmammary gland fat development
Biological Processmicroglial cell proliferation
Biological Processmonocyte differentiation
Biological Processmonocyte homeostasis
Biological Processmyeloid leukocyte migration
Biological Processneutrophil homeostasis
Biological Processossification
Biological Processosteoclast differentiation
Biological Processosteoclast proliferation
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of cell-matrix adhesion
Biological Processpositive regulation of gene expression
Biological Processpositive regulation of leukocyte migration
Biological Processpositive regulation of macrophage chemotaxis
Biological Processpositive regulation of macrophage colony-stimulating factor signaling pathway
Biological Processpositive regulation of macrophage derived foam cell differentiation
Biological Processpositive regulation of macrophage differentiation
Biological Processpositive regulation of macrophage migration
Biological Processpositive regulation of macrophage proliferation
Biological Processpositive regulation of microglial cell migration
Biological Processpositive regulation of monocyte differentiation
Biological Processpositive regulation of mononuclear cell migration
Biological Processpositive regulation of mononuclear cell proliferation
Biological Processpositive regulation of multicellular organism growth
Biological Processpositive regulation of odontogenesis of dentin-containing tooth
Biological Processpositive regulation of osteoclast differentiation
Biological Processpositive regulation of protein metabolic process
Biological Processpositive regulation of Ras protein signal transduction
Biological ProcessRas protein signal transduction
Biological Processregulation of ossification
Biological Processresponse to ischemia
Biological Processresponse to lipopolysaccharide
Biological Processresponse to mechanical stimulus
Biological Processresponse to organic cyclic compound

Keywords

Enzyme and pathway databases

    • R-RNO-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
    • R-RNO-449836Other interleukin signaling
    • R-RNO-8957275Post-translational protein phosphorylation

Names & Taxonomy

Protein names

Gene names

    • Name
      Csf1
    • Synonyms
      Csfm

Organism names

  • Taxonomic identifier
  • Strains
    • Brown Norway/SsN
    • Lewis/N
    • Fischer 344
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q8JZQ0

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein

Processed macrophage colony-stimulating factor 1

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain33-508Extracellular
Transmembrane509-531Helical
Topological domain532-566Cytoplasmic

Keywords

Phenotypes & Variants

Involvement in disease

  • A defect in Csf1 is the cause of the toothless phenotype (tl). Toothless rats display osteoclastopenia, severe osteopetrosis, and dystrophic growth plates

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-32
ChainPRO_000045779333-254Macrophage colony-stimulating factor 1 43 kDa subunit
ChainPRO_000029623333-442Processed macrophage colony-stimulating factor 1
ChainPRO_000000585933-566Macrophage colony-stimulating factor 1
Glycosylation106N-linked (GlcNAc...) asparagine
Glycosylation153N-linked (GlcNAc...) asparagine
Glycosylation171N-linked (GlcNAc...) asparagine
Glycosylation302O-linked (Xyl...) (chondroitin sulfate) serine
Glycosylation353N-linked (GlcNAc...) asparagine
Glycosylation355O-linked (GalNAc...) threonine
Glycosylation357O-linked (GalNAc...) threonine

Post-translational modification

N-glycosylated.
O-glycosylated; contains chondroitin sulfate.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer or heterodimer; disulfide-linked. Likely to exist in multiple forms: homodimer consisting of 2 identical 150-200 kDa proteoglycan subunits, heterodimer consisting of a 150-200 kDa proteoglycan subunit and a truncated 43 kDa subunit, and a homodimer consisting of 2 identical 43 kDa subunits. Interacts with CSF1R.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region197-417Disordered
Compositional bias251-270Polar residues
Compositional bias312-326Polar residues
Compositional bias342-380Polar residues
Compositional bias394-408Polar residues
Region434-484Disordered
Region538-566Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 1 isoforms produced by Alternative splicing. 2 isoforms may be produced.

Q8JZQ0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    566
  • Mass (Da)
    62,187
  • Last updated
    2002-10-01 v1
  • Checksum
    067BBAE5BC28D892
MTARGAAGRCPSSTWMGSRLLLVCLLVSRSVAEVSEHCSHMIGNGHLQILQQLIDSQMETACLIEYKFVDQEQLDDPVCYLKKAFVLVQVIIEETMRFKDNTPNANATERLQELSMKLNSCFIKDYKEQNEACVQTYKESPLRLLEKIKNFFNETKNFLEKDWNIFSKNCNDSFAKCSSRDVVTKPDCNCLYPKATPSSDLASASPHQPPAPSMAPLADLAWDDSQRTEGSSLLPSDLPLRIEDPGSAKQRPPRSTCQTLESTEQPNHEDPQPHPSAGAPIPGVEDIIESSMGTNWVLEEASGEASEGFLTQERKFSPSNPVGGSIQAETDRPWARSASSPFPKLTEDQQPTNITDTPLTEVNPMRPTGQTLNNTPEKTDGSSTLREDQQEPRSPHFATLNPQRVGNSATPYAKLLPPKSHSWGIVLPLGELEGKKSTRDRRSPAELKGGPASEGAARPVAQSTRDRRSPAELKGGPASEGAARPVARFNSIPLTDTGSSIQDPQTSAFVFWVLGIILVLLAVGGLLFYSWKRRSHRDPRTLDSSVGRPEGSSLAQDEDRQVELPV

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0G2K4Q6A0A0G2K4Q6_RATCsf1551
A0A8I6AN73A0A8I6AN73_RATCsf1581
A0A8L2QDI9A0A8L2QDI9_RATCsf1593

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias251-270Polar residues
Compositional bias312-326Polar residues
Compositional bias342-380Polar residues
Compositional bias394-408Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF514355
EMBL· GenBank· DDBJ
AAM54135.1
EMBL· GenBank· DDBJ
mRNA
AF514356
EMBL· GenBank· DDBJ
AAM54136.1
EMBL· GenBank· DDBJ
mRNA
AF515736
EMBL· GenBank· DDBJ
AAM94802.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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