Q8JZP2 · SYN3_MOUSE

  • Protein
    Synapsin-3
  • Gene
    Syn3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity).

Miscellaneous

Regulated by calcium. Calcium inhibits ATP binding to the C-domain (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextrinsic component of synaptic vesicle membrane
Cellular Componentglutamatergic synapse
Cellular Componentpostsynaptic density
Cellular Componentsynapse
Cellular Componentsynaptic vesicle
Cellular Componentsynaptic vesicle membrane
Molecular FunctionATP binding
Biological Processneurotransmitter secretion
Biological Processsynaptic vesicle clustering
Biological Processsynaptic vesicle cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Synapsin-3
  • Alternative names
    • Synapsin III

Gene names

    • Name
      Syn3

Organism names

  • Taxonomic identifier
  • Strains
    • ILS
    • ISS
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8JZP2
  • Secondary accessions
    • E9QNQ6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
; Peripheral membrane protein
Note: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001830251-579Synapsin-3
Modified residue9Phosphoserine
Modified residue454Phosphoserine
Modified residue461Phosphoserine
Modified residue469Phosphoserine
Modified residue474Phosphoserine
Modified residue480Phosphoserine
Modified residue483Phosphoserine
Modified residue540Phosphoserine

Post-translational modification

Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with CAPON.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-28A
Region15-83Disordered
Compositional bias25-40Polar residues
Region28-90B; linker
Compositional bias50-71Polar residues
Region91-398C; actin-binding and synaptic-vesicle binding
Region399-530J; Pro-rich linker
Region401-566Disordered
Compositional bias429-444Pro residues
Compositional bias445-552Polar residues
Region531-579E

Domain

The A region binds phospholipids with a preference for negatively charged species.

Sequence similarities

Belongs to the synapsin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    579
  • Mass (Da)
    63,315
  • Last updated
    2011-07-27 v2
  • Checksum
    2B84E36A1663D50F
MNFLRRRLSDSSFVANLPNGYMPDLQRPESSSSSPASPATERRHPQPLAASFSSPGSSLFSSFSGAMKQTPQAPSGLMEPPTPVTPVVQRPRILLVIDDAHTDWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKIVRSFKPDFILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKMSQLLVPGATVPSPLRPWGPQTKPAKSPGQGQLGPLLGQPQPRPPPQGGPRQAQSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQKSASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETIRNLRKSFASLFSD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D3Z620D3Z620_MOUSESyn3243

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias25-40Polar residues
Compositional bias50-71Polar residues
Sequence conflict65in Ref. 1; AAM22969/AAM22970
Compositional bias429-444Pro residues
Compositional bias445-552Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF498252
EMBL· GenBank· DDBJ
AAM22969.1
EMBL· GenBank· DDBJ
mRNA
AF498253
EMBL· GenBank· DDBJ
AAM22970.1
EMBL· GenBank· DDBJ
mRNA
AC122919
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC124614
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC125060
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC145076
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC150899
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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