Q8JZP2 · SYN3_MOUSE
- ProteinSynapsin-3
- GeneSyn3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids579 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
May be involved in the regulation of neurotransmitter release and synaptogenesis. Binds ATP with high affinity and ADP with a lower affinity. This is consistent with a catalytic role of the C-domain in which ADP would be dissociated by cellular ATP after bound ATP was hydrolyzed (By similarity).
Miscellaneous
Regulated by calcium. Calcium inhibits ATP binding to the C-domain (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of synaptic vesicle membrane | |
Cellular Component | glutamatergic synapse | |
Cellular Component | postsynaptic density | |
Cellular Component | synapse | |
Cellular Component | synaptic vesicle | |
Cellular Component | synaptic vesicle membrane | |
Molecular Function | ATP binding | |
Biological Process | neurotransmitter secretion | |
Biological Process | synaptic vesicle clustering | |
Biological Process | synaptic vesicle cycle |
Keywords
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSynapsin-3
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ8JZP2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein
Note: Peripheral membrane protein localized to the cytoplasmic surface of synaptic vesicles.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000183025 | 1-579 | Synapsin-3 | |||
Sequence: MNFLRRRLSDSSFVANLPNGYMPDLQRPESSSSSPASPATERRHPQPLAASFSSPGSSLFSSFSGAMKQTPQAPSGLMEPPTPVTPVVQRPRILLVIDDAHTDWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKIVRSFKPDFILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKMSQLLVPGATVPSPLRPWGPQTKPAKSPGQGQLGPLLGQPQPRPPPQGGPRQAQSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQKSASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETIRNLRKSFASLFSD | ||||||
Modified residue | 9 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 454 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 461 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 469 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 474 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 480 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 483 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 540 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-28 | A | ||||
Sequence: MNFLRRRLSDSSFVANLPNGYMPDLQRP | ||||||
Region | 15-83 | Disordered | ||||
Sequence: ANLPNGYMPDLQRPESSSSSPASPATERRHPQPLAASFSSPGSSLFSSFSGAMKQTPQAPSGLMEPPTP | ||||||
Compositional bias | 25-40 | Polar residues | ||||
Sequence: LQRPESSSSSPASPAT | ||||||
Region | 28-90 | B; linker | ||||
Sequence: PESSSSSPASPATERRHPQPLAASFSSPGSSLFSSFSGAMKQTPQAPSGLMEPPTPVTPVVQR | ||||||
Compositional bias | 50-71 | Polar residues | ||||
Sequence: ASFSSPGSSLFSSFSGAMKQTP | ||||||
Region | 91-398 | C; actin-binding and synaptic-vesicle binding | ||||
Sequence: PRILLVIDDAHTDWSKYFHGKKVNGDIEIRVEQAEFSELNLAAYVTGGCMVDMQVVRNGTKIVRSFKPDFILVRQHAYSMALAEDYRSLVIGLQYGGLPAVNSLYSVYNFCSKPWVFSQLIKIFHSLGPEKFPLVEQTFFPNHKPMLTAPNFPVVIKLGHAHAGMGKIKVENQHDYQDITSVVAMAKTYATTEAFIDSKYDIRIQKIGSNYKAYMRTSISGNWKANTGSAMLEQVAMTERYRLWVDSCSEMFGGLDICAVKAVHSKDGRDYIIEVMDSSMPLIGEHVEEDKQLMADLVVSKMSQLLVP | ||||||
Region | 399-530 | J; Pro-rich linker | ||||
Sequence: GATVPSPLRPWGPQTKPAKSPGQGQLGPLLGQPQPRPPPQGGPRQAQSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQKSAS | ||||||
Region | 401-566 | Disordered | ||||
Sequence: TVPSPLRPWGPQTKPAKSPGQGQLGPLLGQPQPRPPPQGGPRQAQSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQKSASPHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETI | ||||||
Compositional bias | 429-444 | Pro residues | ||||
Sequence: GQPQPRPPPQGGPRQA | ||||||
Compositional bias | 445-552 | Polar residues | ||||
Sequence: QSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQKSASPHPHLNKSQSLTNSLSTSDTSH | ||||||
Region | 531-579 | E | ||||
Sequence: PHPHLNKSQSLTNSLSTSDTSHRGTPSEDEAKAETIRNLRKSFASLFSD |
Domain
The A region binds phospholipids with a preference for negatively charged species.
Sequence similarities
Belongs to the synapsin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length579
- Mass (Da)63,315
- Last updated2011-07-27 v2
- Checksum2B84E36A1663D50F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D3Z620 | D3Z620_MOUSE | Syn3 | 243 |
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 25-40 | Polar residues | ||||
Sequence: LQRPESSSSSPASPAT | ||||||
Compositional bias | 50-71 | Polar residues | ||||
Sequence: ASFSSPGSSLFSSFSGAMKQTP | ||||||
Sequence conflict | 65 | in Ref. 1; AAM22969/AAM22970 | ||||
Sequence: G → S | ||||||
Compositional bias | 429-444 | Pro residues | ||||
Sequence: GQPQPRPPPQGGPRQA | ||||||
Compositional bias | 445-552 | Polar residues | ||||
Sequence: QSPQPPRSRSPSQQRLSPQGQQPVSPQSGSPQQQRSPGSPQLSRASGGSSPNQASKPSASLSSHNRPPVQGRSTSQQGEEPQKSASPHPHLNKSQSLTNSLSTSDTSH |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF498252 EMBL· GenBank· DDBJ | AAM22969.1 EMBL· GenBank· DDBJ | mRNA | ||
AF498253 EMBL· GenBank· DDBJ | AAM22970.1 EMBL· GenBank· DDBJ | mRNA | ||
AC122919 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC124614 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC125060 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC145076 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC150899 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |