Q8JZN7 · MIRO2_MOUSE

  • Protein
    Mitochondrial Rho GTPase 2
  • Gene
    Rhot2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity).

Features

Showing features for binding site.

162050100150200250300350400450500550600
TypeIDPosition(s)Description
Binding site11-18GTP 1 (UniProtKB | ChEBI)
Binding site57-61GTP 1 (UniProtKB | ChEBI)
Binding site118-121GTP 1 (UniProtKB | ChEBI)
Binding site197Ca2+ 1 (UniProtKB | ChEBI)
Binding site199Ca2+ 1 (UniProtKB | ChEBI)
Binding site201Ca2+ 1 (UniProtKB | ChEBI)
Binding site208Ca2+ 1 (UniProtKB | ChEBI)
Binding site317Ca2+ 2 (UniProtKB | ChEBI)
Binding site319Ca2+ 2 (UniProtKB | ChEBI)
Binding site321Ca2+ 2 (UniProtKB | ChEBI)
Binding site328Ca2+ 2 (UniProtKB | ChEBI)
Binding site424-431GTP 2 (UniProtKB | ChEBI)
Binding site461-465GTP 2 (UniProtKB | ChEBI)
Binding site526-529GTP 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentmitochondrial outer membrane
Cellular Componentmitochondrion
Molecular Functioncalcium ion binding
Molecular FunctionGTP binding
Molecular FunctionGTPase activity
Biological Processcellular homeostasis
Biological Processmitochondrial outer membrane permeabilization
Biological Processmitochondrion organization
Biological Processmitochondrion transport along microtubule
Biological Processsmall GTPase-mediated signal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mitochondrial Rho GTPase 2
  • EC number
  • Short names
    MIRO-2
  • Alternative names
    • Ras homolog gene family member T2

Gene names

    • Name
      Rhot2
    • Synonyms
      Arht2

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q8JZN7

Proteomes

Organism-specific databases

Subcellular Location

Mitochondrion outer membrane
; Single-pass type IV membrane protein
Note: Colocalizes with MGARP and RHOT2 at the mitochondria.

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-594Cytoplasmic
Transmembrane595-617Helical; Anchor for type IV membrane protein
Topological domain618-620Mitochondrial intermembrane

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002393191-620Mitochondrial Rho GTPase 2

Post-translational modification

Ubiquitinated by PRKN in a PINK1-dependent manner, leading to its degradation.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitously expressed.

Gene expression databases

Interaction

Subunit

Interacts with the kinesin-binding proteins TRAK1/OIP106 and TRAK2/GRIF1, forming a link between mitochondria and the trafficking apparatus of the microtubules (By similarity).
Interacts with ARMCX3 (PubMed:22569362).
Found in a complex with KIF5B, OGT, RHOT1 and TRAK1 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-168Miro 1
Domain184-219EF-hand 1
Domain304-339EF-hand 2
Domain415-578Miro 2

Sequence similarities

Belongs to the mitochondrial Rho GTPase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    620
  • Mass (Da)
    69,071
  • Last updated
    2002-10-01 v1
  • Checksum
    439D7AA800730B53
MRRDVRILLLGEAQVGKTSLILSLVGEEFPEEVPARAEEITIPADVTPEKVPTHIVDYSEAEQTEEELQEEIHKANVVCVVYDVSEETTIEKIRTKWIPLVNGRTATGPRLPIILVGNKSDLRPGSTMEAVLPIMSQFPEIETCVECSAKHLRNISELFYYAQKAVLHPTAPLYDPEAKQLRPACAQALTRIFRLSDQDRDHGLSDEELNAFQKSCFGHPLAPQALEDVKRVVCKNVSGGVQNDRLTLEGFLFLNTLFIQRGRHETTWTILRRFGYSDSLELTPDYLYPALHVPPGCSTELNHRGYQFVQRMFEKHDQDHDGVLSPTELQNLFSVFSGAPWGPELLHTVPTQAGCLPLHGYLCQWTLMTYLDVQQCLAHLGYLGYPTLCEQDSQAQAITVTREKKLDQEKGQTQRSVLMCKVLGARGVGKSAFLQAFLGNSLGEARDPPEKFPLHTINTVRVNGQEKYLILCEVNADSLLDTSLDTTCDVACLMFDSSDPKTFVHCATIYKRYYMDGQTPCLFIASKADLPEGVAPPGLSPAEFCRRHRLPAPASFSCLGPAMPSTDVFTQLATMATFPHLVHTELHPTSFWLRGVLVAVGTAVAAVLSFSLYRVLVKSR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H3BL14H3BL14_MOUSERhot2172
H3BKL2H3BKL2_MOUSERhot2121

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY311390
EMBL· GenBank· DDBJ
AAP78906.1
EMBL· GenBank· DDBJ
mRNA
BC029777
EMBL· GenBank· DDBJ
AAH29777.1
EMBL· GenBank· DDBJ
mRNA
BC034062
EMBL· GenBank· DDBJ
AAH34062.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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