Q8JIG0 · PA2BQ_PROFL
- ProteinBasic phospholipase A2 PLA-B'
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids138 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H+
Cofactor
Note: Binds 1 Ca2+ ion.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 43 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 45 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 47 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 63 | ||||
Binding site | 64 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 105 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Molecular Function | calcium ion binding | |
Molecular Function | calcium-dependent phospholipase A2 activity | |
Molecular Function | phospholipid binding | |
Molecular Function | toxin activity | |
Biological Process | arachidonic acid secretion | |
Biological Process | lipid catabolic process | |
Biological Process | phospholipid metabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBasic phospholipase A2 PLA-B'
- EC number
- Short namessvPLA2
- Alternative names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Viperidae > Crotalinae > Protobothrops
Accessions
- Primary accessionQ8JIG0
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-16 | ||||
Chain | PRO_0000022956 | 17-138 | Basic phospholipase A2 PLA-B' | ||
Disulfide bond | 42↔131 | ||||
Disulfide bond | 44↔60 | ||||
Disulfide bond | 59↔111 | ||||
Disulfide bond | 65↔138 | ||||
Disulfide bond | 66↔104 | ||||
Disulfide bond | 73↔97 | ||||
Disulfide bond | 91↔102 | ||||
Keywords
- PTM
Expression
Tissue specificity
Expressed by the venom gland.
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length138
- Mass (Da)15,703
- Last updated2002-10-01 v1
- ChecksumCBDE540581DD2F10
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB087496 EMBL· GenBank· DDBJ | BAC02719.1 EMBL· GenBank· DDBJ | mRNA |