Q8JHZ6 · Q8JHZ6_DANRE
- ProteinTumor protein 63 (p63)
- Genetp63
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids588 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | epidermis morphogenesis | |
Biological Process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | protein tetramerization | |
Biological Process | regulation of ectodermal cell fate specification | |
Biological Process | regulation of programmed necrotic cell death | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTumor protein 63 (p63)
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ8JHZ6
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 265 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Keywords
- PTM
Interaction
Subunit
Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 21-75 | Disordered | ||||
Sequence: GLLNSMDQNGGSTSTSPYNNDHAQNNVTAPSPYAQPSSTFEALSPSPAIPSNTDY | ||||||
Compositional bias | 339-402 | Polar residues | ||||
Sequence: QQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPSGMPGGLTDSLLQSQPF | ||||||
Region | 339-420 | Disordered | ||||
Sequence: QQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPSGMPGGLTDSLLQSQPFPLPSVTPPMMGGPVPMNT | ||||||
Domain | 447-513 | SAM | ||||
Sequence: PPYPMDNSISSFLLRLGCSACLDYFTAQGLTNIYQIENYNLEDLSRLKIPTEFQHIIWKGIMEYRQT |
Sequence similarities
Belongs to the p53 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length588
- Mass (Da)65,474
- Last updated2002-10-01 v1
- ChecksumCFD1A83172009B1B
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 339-402 | Polar residues | ||||
Sequence: QQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPSGMPGGLTDSLLQSQPF |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF412283 EMBL· GenBank· DDBJ | AAN03690.1 EMBL· GenBank· DDBJ | mRNA |