Q8JFG2 · PA2H_LATSE

Function

function

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site55Ca2+ (UniProtKB | ChEBI)
Binding site57Ca2+ (UniProtKB | ChEBI)
Binding site59Ca2+ (UniProtKB | ChEBI)
Active site75
Binding site76Ca2+ (UniProtKB | ChEBI)
Active site126

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Molecular Functioncalcium ion binding
Molecular Functioncalcium-dependent phospholipase A2 activity
Molecular Functionphospholipid binding
Molecular Functionsignaling receptor binding
Biological Processarachidonic acid secretion
Biological Processfatty acid biosynthetic process
Biological Processlipid catabolic process
Biological Processphospholipid metabolic process
Biological Processpositive regulation of fibroblast proliferation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A2 pkP2
  • EC number
  • Alternative names
    • Phosphatidylcholine 2-acylhydrolase

Organism names

Accessions

  • Primary accession
    Q8JFG2

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
PropeptidePRO_000002291222-27
ChainPRO_000002291328-152Phospholipase A2 pkP2
Disulfide bond38↔104
Disulfide bond54↔151
Disulfide bond56↔72
Disulfide bond71↔132
Disulfide bond78↔125
Disulfide bond88↔118
Disulfide bond111↔123

Keywords

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    152
  • Mass (Da)
    16,374
  • Last updated
    2002-10-01 v1
  • Checksum
    F763BAD02C11BFEB
MNPAHLLVLLAVCVSLLGASAIPPLPLNLVQFSNMIKCTIPGSRPLLDYADYGCYCGAGGSGTPVDESDRCCQTHDNCYSQAKKHPACKSPLDSPYIKIYSYTCSGGSLTCRDDNDECGAFICNCDRTAAICFAGAPYNKENYNIDTKKHCK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB078347
EMBL· GenBank· DDBJ
BAC03246.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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