Q8JFE3 · Q8JFE3_DANRE
- ProteinTumor protein 63 (p63)
- Genetp63
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids576 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for site, binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | DNA binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Biological Process | epidermis morphogenesis | |
Biological Process | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | |
Biological Process | negative regulation of DNA-templated transcription | |
Biological Process | protein tetramerization | |
Biological Process | regulation of ectodermal cell fate specification | |
Biological Process | regulation of programmed necrotic cell death | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTumor protein 63 (p63)
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionQ8JFE3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Cross-link | 265 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Keywords
- PTM
Expression
Gene expression databases
Interaction
Subunit
Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 21-75 | Disordered | ||||
Sequence: GLLNSMDQNGGSTSTSPYNNDHAQNNVTAPSPYAQPSSTFEALSPSPAIPSNTDY | ||||||
Compositional bias | 339-386 | Polar residues | ||||
Sequence: QQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPS | ||||||
Region | 339-402 | Disordered | ||||
Sequence: QQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPSGMPGGLTDMTPPMMGG | ||||||
Domain | 435-501 | SAM | ||||
Sequence: PPYPMDNSISSFLLRLGCSACLDYFTAQGLTNIYQIENYNLEDLSRLKIPTEFQHIIWKGIMEYRQT | ||||||
Region | 557-576 | Disordered | ||||
Sequence: FDLAPDSRRNKQQRIKEEGE |
Sequence similarities
Belongs to the p53 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length576
- Mass (Da)64,168
- Last updated2002-10-01 v1
- Checksum2CCA5084D54BD0CA
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for compositional bias, non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 339-386 | Polar residues | ||||
Sequence: QQQNLLQKQSSLPPQPAFGSSSPTLGKNKLPSVSQLINPQQRNALTPS | ||||||
Non-terminal residue | 576 | |||||
Sequence: E |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX004773 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BX004878 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AF487944 EMBL· GenBank· DDBJ | AAM48108.1 EMBL· GenBank· DDBJ | mRNA | ||
AF412284 EMBL· GenBank· DDBJ | AAN03691.1 EMBL· GenBank· DDBJ | mRNA |