Entospletinib in Combination with Induction Chemotherapy in Previously Untreated Acute Myeloid Leukemia: Response and Predictive Significance of HOXA9 and MEIS1 Expression.
Meis homeobox 1(MEIS1) may contribute to the cancer-promoting actions of homeobox protein Hox-B13(HOXB13) in cellular proliferation and gene regulation by prolonging HOXB13 half-life in prostate cancer
Through integrative analysis we identify MEIS1 as a super-enhancer-driven oncogene which co-operates with EWS-FLI1 in transcriptional regulation and plays a key pro-survival role in Ewing sarcoma. Moreover APCDD1 another super-enhancer-associated gene acting as a downstream target of both MEIS1 and EWS-FLI1 is also characterized as a novel tumor-promoting factor in this malignancy
MEIS1 induces the expression of CCL18 CCL4 CXCL7 CCL5 CXCL1 and IL8 chemokines in ovarian cancer cells followed by their secretion in the culture medium ultimately triggering CD8+ T-lymphocyte recruitment in vitro.
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