Q8IZX4 · TAF1L_HUMAN
- ProteinTranscription initiation factor TFIID subunit 1-like
- GeneTAF1L
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids1826 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May act as a functional substitute for TAF1/TAFII250 during male meiosis, when sex chromosomes are transcriptionally silenced.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | nucleoplasm | |
Cellular Component | transcription factor TFIID complex | |
Molecular Function | DNA binding | |
Molecular Function | histone acetyltransferase activity | |
Molecular Function | lysine-acetylated histone binding | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | RNA polymerase II general transcription initiation factor activity | |
Molecular Function | TBP-class protein binding | |
Biological Process | male meiotic nuclear division | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | RNA polymerase II preinitiation complex assembly |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscription initiation factor TFIID subunit 1-like
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8IZX4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_041934 | 47 | in a lung small cell carcinoma sample; somatic mutation | |||
Sequence: G → A | ||||||
Natural variant | VAR_041935 | 171 | in dbSNP:rs56352331 | |||
Sequence: Q → E | ||||||
Natural variant | VAR_041936 | 256 | in dbSNP:rs55991718 | |||
Sequence: G → A | ||||||
Natural variant | VAR_041937 | 371 | in dbSNP:rs17219559 | |||
Sequence: M → V | ||||||
Natural variant | VAR_041938 | 532 | in dbSNP:rs56128445 | |||
Sequence: I → N | ||||||
Natural variant | VAR_041939 | 637 | in dbSNP:rs56157814 | |||
Sequence: P → S | ||||||
Natural variant | VAR_041940 | 750 | in a lung adenocarcinoma sample; somatic mutation | |||
Sequence: L → F | ||||||
Natural variant | VAR_041941 | 762 | in a lung adenocarcinoma sample; somatic mutation | |||
Sequence: L → I | ||||||
Natural variant | VAR_041942 | 794 | in a lung adenocarcinoma sample; somatic mutation | |||
Sequence: E → D | ||||||
Natural variant | VAR_041943 | 845 | in dbSNP:rs34787787 | |||
Sequence: R → Q | ||||||
Natural variant | VAR_041944 | 1016 | in dbSNP:rs35905429 | |||
Sequence: R → C | ||||||
Natural variant | VAR_041945 | 1038 | in dbSNP:rs55767137 | |||
Sequence: K → N | ||||||
Natural variant | VAR_041946 | 1169 | in dbSNP:rs55976674 | |||
Sequence: T → I | ||||||
Natural variant | VAR_041947 | 1312 | in dbSNP:rs55824107 | |||
Sequence: V → L | ||||||
Natural variant | VAR_041948 | 1356 | in dbSNP:rs56107531 | |||
Sequence: R → C | ||||||
Natural variant | VAR_041949 | 1389 | in dbSNP:rs56393725 | |||
Sequence: P → S | ||||||
Natural variant | VAR_041950 | 1411 | in dbSNP:rs34500740 | |||
Sequence: I → V | ||||||
Natural variant | VAR_041951 | 1540 | in dbSNP:rs55782058 | |||
Sequence: A → T | ||||||
Natural variant | VAR_041952 | 1549 | in a glioblastoma multiforme sample; somatic mutation; dbSNP:rs1587670372 | |||
Sequence: H → Y | ||||||
Natural variant | VAR_041953 | 1731 | in dbSNP:rs34241003 | |||
Sequence: K → N | ||||||
Natural variant | VAR_048435 | 1805 | in dbSNP:rs16918393 | |||
Sequence: I → V | ||||||
Natural variant | VAR_041954 | 1810 | in dbSNP:rs56342342 | |||
Sequence: P → L | ||||||
Natural variant | VAR_041955 | 1824 | in a lung adenocarcinoma sample; somatic mutation; dbSNP:rs202147126 | |||
Sequence: H → Q |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2,436 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000211217 | 1-1826 | UniProt | Transcription initiation factor TFIID subunit 1-like | |||
Sequence: MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK | |||||||
Modified residue (large scale data) | 1325 | PRIDE | Phosphothreonine | ||||
Sequence: T |
Proteomic databases
PTM databases
Structure
Family & Domains
Features
Showing features for region, motif, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 118-141 | Disordered | ||||
Sequence: DESQRHQQTMGSLQPLYHSDYDED | ||||||
Region | 532-555 | Disordered | ||||
Sequence: IPDEKEEATSNSPSKESKKESSLK | ||||||
Region | 1252-1276 | Disordered | ||||
Sequence: RLKRNQEKEKLKGPPEKKPKKMKER | ||||||
Motif | 1370-1377 | Nuclear localization signal | ||||
Sequence: PPKKKRRV | ||||||
Domain | 1416-1486 | Bromo 1 | ||||
Sequence: RDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLT | ||||||
Domain | 1539-1609 | Bromo 2 | ||||
Sequence: MAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYT | ||||||
Region | 1648-1826 | Disordered | ||||
Sequence: AELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK | ||||||
Compositional bias | 1664-1704 | Polar residues | ||||
Sequence: QPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQM | ||||||
Compositional bias | 1765-1781 | Acidic residues | ||||
Sequence: LISEGEDDEEDAGSDEE |
Sequence similarities
Belongs to the TAF1 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,826
- Mass (Da)207,302
- Last updated2003-03-01 v1
- Checksum35D780E749AC9B17
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1664-1704 | Polar residues | ||||
Sequence: QPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQM | ||||||
Compositional bias | 1765-1781 | Acidic residues | ||||
Sequence: LISEGEDDEEDAGSDEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF390562 EMBL· GenBank· DDBJ | AAN40840.1 EMBL· GenBank· DDBJ | mRNA |