Q8IZL9 · CDK20_HUMAN
- ProteinCyclin-dependent kinase 20
- GeneCDK20
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids346 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for high-level Shh responses in the developing neural tube. Together with TBC1D32, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to SHH signaling (By similarity).
Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'
Involved in cell growth. Activates CDK2, a kinase involved in the control of the cell cycle, by phosphorylating residue 'Thr-160'
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cilium | |
Cellular Component | cytoplasm | |
Cellular Component | nucleoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | cyclin-dependent protein serine/threonine kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Biological Process | cell division | |
Biological Process | embryonic brain development | |
Biological Process | embryonic camera-type eye development | |
Biological Process | embryonic skeletal system development | |
Biological Process | floor plate formation | |
Biological Process | negative regulation of smoothened signaling pathway | |
Biological Process | neural tube closure | |
Biological Process | protein localization to cilium | |
Biological Process | regulation of protein maturation | |
Biological Process | roof of mouth development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCyclin-dependent kinase 20
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8IZL9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Features
Showing features for natural variant, mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_024762 | 86 | in dbSNP:rs28364953 | |||
Sequence: S → L | ||||||
Natural variant | VAR_041957 | 106 | in dbSNP:rs41286029 | |||
Sequence: S → N | ||||||
Natural variant | VAR_024763 | 137 | in dbSNP:rs28364955 | |||
Sequence: A → T | ||||||
Mutagenesis | 161 | Impairs CDK2 T-160 phosphorylation and activity. | ||||
Sequence: T → A | ||||||
Natural variant | VAR_024764 | 281 | in dbSNP:rs28364963 | |||
Sequence: K → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 511 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000085701 | 1-346 | Cyclin-dependent kinase 20 | |||
Sequence: MDQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFFTAPLPAHPSELPIPQRLGGPAPKAHPGPPHIHDFHVDRPLEESLLNPELIRPFILEG |
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Monomer. Interacts with TBC1D32 (By similarity).
Interacts with MAK
Interacts with MAK
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8IZL9 | TRIM2 Q9C040 | 3 | EBI-6128565, EBI-749840 |
Protein-protein interaction databases
Chemistry
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 4-288 | Protein kinase | ||||
Sequence: YCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDNQYVVQLKAVFPHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCHANNIVHRDLKPANLLISASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYF |
Sequence similarities
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 5 isoforms produced by Alternative splicing.
Q8IZL9-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length346
- Mass (Da)38,695
- Last updated2003-03-01 v1
- ChecksumEB6A53E97301D5AE
Q8IZL9-2
- Name2
- SynonymsCardiac CCRK
Q8IZL9-3
- Name3
Q8IZL9-4
- Name4
Q8IZL9-5
- Name5
- Differences from canonical
- 168-188: Missing
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_043294 | 25 | in isoform 4 | |||
Sequence: E → EPRVGWQCLPSILQ | ||||||
Sequence conflict | 30 | in Ref. 1; AAC98920 and 2; AAF43778 | ||||
Sequence: V → I | ||||||
Alternative sequence | VSP_016749 | 168-188 | in isoform 3, isoform 4 and isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_016748 | 168-243 | in isoform 2 | |||
Sequence: WYRAPELLYGARQYDQGVDLWSVGCIMGELLNGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTELPDYNKISFK → SSLSCRTTTRSPLRSRCPCPWRRCCLTSLPRHWICWVNSFSTLLTSASQLPRLSSISTSSQLPCLPIHLSCRFLSV | ||||||
Alternative sequence | VSP_016750 | 244-346 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_016751 | 282-296 | in isoform 3 | |||
Sequence: ALLHQYFFTAPLPAH → LPCLPIHLSCRFLSV | ||||||
Alternative sequence | VSP_016752 | 297-346 | in isoform 3 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF035013 EMBL· GenBank· DDBJ | AAC98920.1 EMBL· GenBank· DDBJ | mRNA | Frameshift | |
AF113130 EMBL· GenBank· DDBJ | AAF43778.1 EMBL· GenBank· DDBJ | mRNA | ||
AY904367 EMBL· GenBank· DDBJ | AAW82349.1 EMBL· GenBank· DDBJ | mRNA | ||
AF547664 EMBL· GenBank· DDBJ | AAN28684.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK075325 EMBL· GenBank· DDBJ | BAG52110.1 EMBL· GenBank· DDBJ | mRNA | ||
AK298993 EMBL· GenBank· DDBJ | BAG61083.1 EMBL· GenBank· DDBJ | mRNA | ||
AL353572 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471089 EMBL· GenBank· DDBJ | EAW62746.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471089 EMBL· GenBank· DDBJ | EAW62748.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC002655 EMBL· GenBank· DDBJ | AAH02655.1 EMBL· GenBank· DDBJ | mRNA |