Q8IYR2 · SMYD4_HUMAN

  • Protein
    SET and MYND domain-containing protein 4
  • Gene
    SMYD4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Plays a critical role in cardiac development (PubMed:30110327).
Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity).

Features

Showing features for binding site.

1804100200300400500600700800
TypeIDPosition(s)Description
Binding site112-114S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site296Zn2+ 1 (UniProtKB | ChEBI)
Binding site299Zn2+ 1 (UniProtKB | ChEBI)
Binding site309Zn2+ 2 (UniProtKB | ChEBI)
Binding site312Zn2+ 2 (UniProtKB | ChEBI)
Binding site318Zn2+ 1 (UniProtKB | ChEBI)
Binding site322Zn2+ 1 (UniProtKB | ChEBI)
Binding site331Zn2+ 2 (UniProtKB | ChEBI)
Binding site335Zn2+ 2 (UniProtKB | ChEBI)
Binding site427S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site539-540S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site573S-adenosyl-L-methionine (UniProtKB | ChEBI)
Binding site595S-adenosyl-L-methionine (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular Functionhistone deacetylase binding
Molecular Functionmetal ion binding
Molecular Functionmethyltransferase activity
Biological Processheart development
Biological Processmethylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    SET and MYND domain-containing protein 4
  • EC number

Gene names

    • Name
      SMYD4
    • Synonyms
      KIAA1936

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8IYR2
  • Secondary accessions
    • Q8N1P2
    • Q8NAT0
    • Q96LV4
    • Q96PV2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_057495101in dbSNP:rs9907701
Natural variantVAR_025626131in dbSNP:rs7224496
Natural variantVAR_057496236in dbSNP:rs9913923
Natural variantVAR_084711345found in a patient with congenital heart defect; uncertain significance; loss of interaction with HDAC1; fails to rescue the abnormal cardiac phenotypes defects in zebrafish morphants; dbSNP:rs759042432
Natural variantVAR_057497374in dbSNP:rs9890631
Natural variantVAR_057498382in dbSNP:rs3809875
Natural variantVAR_025628562in dbSNP:rs11549830
Natural variantVAR_084712579found in a patient with congenital heart defect; uncertain significance; dbSNP:rs766983285
Natural variantVAR_064755601found in a renal cell carcinoma sample; somatic mutation
Natural variantVAR_025627727in dbSNP:rs9902398

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 967 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002277841-804SET and MYND domain-containing protein 4

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts (via MYND-type zinc finger) with HDAC1.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, zinc finger.

TypeIDPosition(s)Description
Domain233-574SET
Zinc finger296-335MYND-type

Sequence similarities

Belongs to the class V-like SAM-binding methyltransferase superfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    804
  • Mass (Da)
    89,225
  • Last updated
    2010-05-18 v3
  • Checksum
    982F8BFEF40A49A2
MDLPVDEWKSYLLQKWASLPTSVQVTISTAETLRDIFLHSSSLLQPEDELFLKRLSKGYLVGKDSDAPLFYREEGNKKFQEKDYTGAAVLYSKGVSHSRPNTEDMSLCHANRSAALFHLGQYETCLKDINRAQTHGYPERLQPKIMLRKAECLVALGRLQEASQTISDLERNFTATPALADVLPQTLQRNLHRLKMKMQEKDSLTESFPAALAKTLEDAALREENEQLSNASSSIGLCVDPLKGRCLVATKDILPGELLVQEDAFVSVLNPGELPPPHHGLDSKWDTRVTNGDLYCHRCLKHTLATVPCDGCSYAKYCSQECLQQAWELYHRTECPLGGLLLTLGVFCHIALRLTLLVGFEDVRKIITKLCDKISNKDICLPESNNQVKTLNYGLGESEKNGNIVETPIPGCDINGKYENNYNAVFNLLPHTENHSPEHKFLCALCVSALCRQLEAASLQAIPTERIVNSSQLKAAVTPELCPDVTIWGVAMLRHMLQLQCNAQAMTTIQHTGPKGSIVTDSRQVRLATGIFPVISLLNHSCSPNTSVSFISTVATIRASQRIRKGQEILHCYGPHKSRMGVAERQQKLRSQYFFDCACPACQTEAHRMAAGPRWEAFCCNSCGAPMQGDDVLRCGSRSCAESAVSRDHLVSRLQDLQQQVRVAQKLLRDGELERAVQRLSGCQRDAESFLWAEHAVVGEIADGLARACAALGDWQKSATHLQRSLYVVEVRHGPSSVEMGHELFKLAQIFFNGFAVPEALSTIQKAEEVLSLHCGPWDDEIQELQKMKSCLLDLPPTPVGPAL

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
I3L496I3L496_HUMANSMYD4177
I3L428I3L428_HUMANSMYD4558
I3L2P4I3L2P4_HUMANSMYD4223
I3L1V4I3L1V4_HUMANSMYD472

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict326in Ref. 2; AAH35077
Sequence conflict511in Ref. 1; BAC04538
Sequence conflict514in Ref. 1; BAC04538

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AK057769
EMBL· GenBank· DDBJ
BAB71564.1
EMBL· GenBank· DDBJ
mRNA
AK095369
EMBL· GenBank· DDBJ
BAC04538.1
EMBL· GenBank· DDBJ
mRNA
BC035077
EMBL· GenBank· DDBJ
AAH35077.1
EMBL· GenBank· DDBJ
mRNA
AB067523
EMBL· GenBank· DDBJ
BAB67829.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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