Q8IYP9 · ZDH23_HUMAN

  • Protein
    Palmitoyltransferase ZDHHC23
  • Gene
    ZDHHC23
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.

Catalytic activity

Features

Showing features for active site.

140950100150200250300350400
TypeIDPosition(s)Description
Active site289S-palmitoyl cysteine intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Molecular Functionprotein-cysteine S-palmitoyltransferase activity
Biological Processprotein localization to plasma membrane
Biological Processprotein palmitoylation
Biological Processprotein targeting to membrane

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Palmitoyltransferase ZDHHC23
  • EC number
  • Alternative names
    • Zinc finger DHHC domain-containing protein 23
      (DHHC-23; zDHHC23)

Gene names

    • Name
      ZDHHC23

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8IYP9
  • Secondary accessions
    • D3DN76

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane
; Multi-pass membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-87Cytoplasmic
Transmembrane88-106Helical
Topological domain107-109Lumenal
Transmembrane110-132Helical
Topological domain133-136Cytoplasmic
Transmembrane137-157Helical
Topological domain158-165Lumenal
Transmembrane166-186Helical
Topological domain187-302Cytoplasmic
Transmembrane303-323Helical
Topological domain324-331Lumenal
Transmembrane332-352Helical
Topological domain353Cytoplasmic
Transmembrane354-374Helical
Topological domain375-409Lumenal

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_047389132in dbSNP:rs17853401
Natural variantVAR_047390221in dbSNP:rs17853402
Natural variantVAR_047391247in dbSNP:rs11921691
Natural variantVAR_047392274in dbSNP:rs17857054

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 440 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002129121-409UniProtPalmitoyltransferase ZDHHC23
Modified residue (large scale data)206PRIDEPhosphoserine
Modified residue (large scale data)252PRIDEPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with NOS1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8IYP9GLIS1 Q8NBF13EBI-12111024, EBI-12111022

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region215-255Disordered
Domain259-309DHHC

Domain

The DHHC domain is required for palmitoyltransferase activity.

Sequence similarities

Belongs to the DHHC palmitoyltransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    409
  • Mass (Da)
    45,983
  • Last updated
    2008-11-25 v3
  • Checksum
    6AD65E37DA8F34AD
MTQKGSMKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVATCLCDCQDLDEGCDRWITCKSLQPETCERIMDTISDRLRIPWLRGAKKVNISIIPPLVLLPVFLHVASWHFLLGVVVLTSLPVLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLQEVVPKGRVGPVQLAVLTCGLFLILLALHRAKKNPGYLSNPASGDRSLSSSQLECLSRKGQEKTKGFPGADMSGSLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALLIFLLTSVYGITLTLDTICRDRSVFTALFYCPGVYANYSSALSFTCVWYSVIITAGMAYIFLIQLINISYNVTEREVQQALRQKTGRRLLCGLIVDTGLLG

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PAP7E9PAP7_HUMANZDHHC23412
C9JPJ8C9JPJ8_HUMANZDHHC23148
A0A1W2PRJ8A0A1W2PRJ8_HUMANZDHHC23435
H7C4L2H7C4L2_HUMANZDHHC2375
B3KXV3B3KXV3_HUMANZDHHC23403

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC128687
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471052
EMBL· GenBank· DDBJ
EAW79617.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471052
EMBL· GenBank· DDBJ
EAW79618.1
EMBL· GenBank· DDBJ
Genomic DNA
BC035230
EMBL· GenBank· DDBJ
AAH35230.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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