Q8IYP9 · ZDH23_HUMAN
- ProteinPalmitoyltransferase ZDHHC23
- GeneZDHHC23
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids409 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (Probable). Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.
Catalytic activity
- hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein]This reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 289 | S-palmitoyl cysteine intermediate | ||||
Sequence: C |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum | |
Cellular Component | Golgi apparatus | |
Cellular Component | Golgi membrane | |
Molecular Function | protein-cysteine S-palmitoyltransferase activity | |
Biological Process | protein localization to plasma membrane | |
Biological Process | protein palmitoylation | |
Biological Process | protein targeting to membrane |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePalmitoyltransferase ZDHHC23
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8IYP9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Golgi apparatus membrane ; Multi-pass membrane protein
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-87 | Cytoplasmic | ||||
Sequence: MTQKGSMKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVATCLCDCQDLDEGCDRWITCKSLQPETCERIMDTISDRLRIPWLRGAKK | ||||||
Transmembrane | 88-106 | Helical | ||||
Sequence: VNISIIPPLVLLPVFLHVA | ||||||
Topological domain | 107-109 | Lumenal | ||||
Sequence: SWH | ||||||
Transmembrane | 110-132 | Helical | ||||
Sequence: FLLGVVVLTSLPVLALWYYYLTH | ||||||
Topological domain | 133-136 | Cytoplasmic | ||||
Sequence: RRKE | ||||||
Transmembrane | 137-157 | Helical | ||||
Sequence: QTLFFLSLGLFSLGYMYYVFL | ||||||
Topological domain | 158-165 | Lumenal | ||||
Sequence: QEVVPKGR | ||||||
Transmembrane | 166-186 | Helical | ||||
Sequence: VGPVQLAVLTCGLFLILLALH | ||||||
Topological domain | 187-302 | Cytoplasmic | ||||
Sequence: RAKKNPGYLSNPASGDRSLSSSQLECLSRKGQEKTKGFPGADMSGSLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQ | ||||||
Transmembrane | 303-323 | Helical | ||||
Sequence: AFILALLIFLLTSVYGITLTL | ||||||
Topological domain | 324-331 | Lumenal | ||||
Sequence: DTICRDRS | ||||||
Transmembrane | 332-352 | Helical | ||||
Sequence: VFTALFYCPGVYANYSSALSF | ||||||
Topological domain | 353 | Cytoplasmic | ||||
Sequence: T | ||||||
Transmembrane | 354-374 | Helical | ||||
Sequence: CVWYSVIITAGMAYIFLIQLI | ||||||
Topological domain | 375-409 | Lumenal | ||||
Sequence: NISYNVTEREVQQALRQKTGRRLLCGLIVDTGLLG |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_047389 | 132 | in dbSNP:rs17853401 | |||
Sequence: H → N | ||||||
Natural variant | VAR_047390 | 221 | in dbSNP:rs17853402 | |||
Sequence: T → A | ||||||
Natural variant | VAR_047391 | 247 | in dbSNP:rs11921691 | |||
Sequence: K → R | ||||||
Natural variant | VAR_047392 | 274 | in dbSNP:rs17857054 | |||
Sequence: H → R |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 440 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000212912 | 1-409 | UniProt | Palmitoyltransferase ZDHHC23 | |||
Sequence: MTQKGSMKPVKKKKTEEPELEPLCCCEYIDRNGEKNHVATCLCDCQDLDEGCDRWITCKSLQPETCERIMDTISDRLRIPWLRGAKKVNISIIPPLVLLPVFLHVASWHFLLGVVVLTSLPVLALWYYYLTHRRKEQTLFFLSLGLFSLGYMYYVFLQEVVPKGRVGPVQLAVLTCGLFLILLALHRAKKNPGYLSNPASGDRSLSSSQLECLSRKGQEKTKGFPGADMSGSLNNRTTKDDPKGSSKMPAGSPTKAKEDWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALLIFLLTSVYGITLTLDTICRDRSVFTALFYCPGVYANYSSALSFTCVWYSVIITAGMAYIFLIQLINISYNVTEREVQQALRQKTGRRLLCGLIVDTGLLG | |||||||
Modified residue (large scale data) | 206 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 252 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts with NOS1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8IYP9 | GLIS1 Q8NBF1 | 3 | EBI-12111024, EBI-12111022 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 215-255 | Disordered | ||||
Sequence: RKGQEKTKGFPGADMSGSLNNRTTKDDPKGSSKMPAGSPTK | ||||||
Domain | 259-309 | DHHC | ||||
Sequence: DWCAKCQLVRPARAWHCRICGICVRRMDHHCVWINSCVGESNHQAFILALL |
Domain
The DHHC domain is required for palmitoyltransferase activity.
Sequence similarities
Belongs to the DHHC palmitoyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length409
- Mass (Da)45,983
- Last updated2008-11-25 v3
- Checksum6AD65E37DA8F34AD
Computationally mapped potential isoform sequences
There are 5 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
E9PAP7 | E9PAP7_HUMAN | ZDHHC23 | 412 | ||
C9JPJ8 | C9JPJ8_HUMAN | ZDHHC23 | 148 | ||
A0A1W2PRJ8 | A0A1W2PRJ8_HUMAN | ZDHHC23 | 435 | ||
H7C4L2 | H7C4L2_HUMAN | ZDHHC23 | 75 | ||
B3KXV3 | B3KXV3_HUMAN | ZDHHC23 | 403 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC128687 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471052 EMBL· GenBank· DDBJ | EAW79617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471052 EMBL· GenBank· DDBJ | EAW79618.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC035230 EMBL· GenBank· DDBJ | AAH35230.2 EMBL· GenBank· DDBJ | mRNA |