Q8IYF3 · TEX11_HUMAN
- ProteinTestis-expressed protein 11
- GeneTEX11
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids940 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Regulator of crossing-over during meiosis. Involved in initiation and/or maintenance of chromosome synapsis and formation of crossovers.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | central element | |
Cellular Component | chromosome | |
Biological Process | apoptotic process | |
Biological Process | chiasma assembly | |
Biological Process | ectopic germ cell programmed cell death | |
Biological Process | fertilization | |
Biological Process | male gonad development | |
Biological Process | male meiosis chromosome segregation | |
Biological Process | meiotic gene conversion | |
Biological Process | negative regulation of apoptotic process | |
Biological Process | negative regulation of developmental process | |
Biological Process | negative regulation of reproductive process | |
Biological Process | reciprocal meiotic recombination | |
Biological Process | resolution of meiotic recombination intermediates | |
Biological Process | synaptonemal complex assembly |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTestis-expressed protein 11
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ8IYF3
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Forms arrays of discrete foci along synaptonemal complexes in spermatocytes and fetal oocytes.
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Spermatogenic failure, X-linked, 2 (SPGFX2)
- Note
- DescriptionAn infertility disorder caused by spermatogenesis defects. It is characterized by mixed testicular atrophy and azoospermia with meiotic arrest.
- See alsoMIM:309120
Natural variants in SPGFX2
Variant ID | Position(s) | Change | Description | |
---|---|---|---|---|
VAR_073889 | 171 | M>V | in SPGFX2; dbSNP:rs143246552 | |
VAR_073890 | 698 | A>T | in SPGFX2; dbSNP:rs140984555 |
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_034635 | 130 | in dbSNP:rs6525433 | |||
Sequence: K → R | ||||||
Natural variant | VAR_073889 | 171 | in SPGFX2; dbSNP:rs143246552 | |||
Sequence: M → V | ||||||
Natural variant | VAR_034636 | 451 | in dbSNP:rs4844247 | |||
Sequence: E → K | ||||||
Natural variant | VAR_073890 | 698 | in SPGFX2; dbSNP:rs140984555 | |||
Sequence: A → T |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 767 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000296955 | 1-940 | UniProt | Testis-expressed protein 11 | |||
Sequence: MISAHCNLRLLCSSDSSASASQVAGTTEVVENLVTNDNSPNIPEAIDRLFSDIANINRESMAEITDIQIEEMAVNLWNWALTIGGGWLVNEEQKIRLHYVACKLLSMCEASFASEQSIQRLIMMNMRIGKEWLDAGNFLIADECFQAAVASLEQLYVKLIQRSSPEADLTMEKITVESDHFRVLSYQAESAVAQGDFQRASMCVLQCKDMLMRLPQMTSSLHHLCYNFGVETQKNNKYEESSFWLSQSYDIGKMDKKSTGPEMLAKVLRLLATNYLDWDDTKYYDKALNAVNLANKEHLSSPGLFLKMKILLKGETSNEELLEAVMEILHLDMPLDFCLNIAKLLMDHERESVGFHFLTIIHERFKSSENIGKVLILHTDMLLQRKEELLAKEKIEEIFLAHQTGRQLTAESMNWLHNILWRQAASSFEVQNYTDALQWYYYSLRFYSTDEMDLDFTKLQRNMACCYLNLQQLDKAKEAVAEAERHDPRNVFTQFYIFKIAVIEGNSERALQAIITLENILTDEESEDNDLVAERGSPTMLLSLAAQFALENGQQIVAEKALEYLAQHSEDQEQVLTAVKCLLRFLLPKIAEMPESEDKKKEMDRLLTCLNRAFVKLSQPFGEEALSLESRANEAQWFRKTAWNLAVQCDKDPVMMREFFILSYKMSQFCPSDQVILIARKTCLLMAVAVDLEQGRKASTAFEQTMFLSRALEEIQTCNDIHNFLKQTGTFSNDSCEKLLLLYEFEVRAKLNDPLLESFLESVWELPHLETKTFETIAIIAMEKPAHYPLIALKALKKALLLYKKEEPIDISQYSKCMHNLVNLSVPDGASNVELCPLEEVWGYFEDALSHISRTKDYPEMEILWLMVKSWNTGVLMFSRSKYASAEKWCGLALRFLNHLTSFKESYETQMNMLYSQLVEALSNNKGPVFHEHGYWSKSD | |||||||
Modified residue (large scale data) | 178 | PRIDE | Phosphoserine | ||||
Sequence: S |
Proteomic databases
PTM databases
Interaction
Subunit
Interacts with SYCP2. Interacts with PBXIP1; may prevent interaction between PBXIP1 and ESR2 (By similarity).
Interacts with SHOC1 (PubMed:29742103).
Interacts with REDIC1
Interacts with SHOC1 (PubMed:29742103).
Interacts with REDIC1
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q8IYF3-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length940
- Mass (Da)107,889
- Last updated2007-07-24 v3
- Checksum20A3B0BF58B82EF9
Q8IYF3-2
- Name2
- Differences from canonical
- 1-325: Missing
Q8IYF3-3
- Name3
- Differences from canonical
- 1-27: MISAHCNLRLLCSSDSSASASQVAGTT → MDNDDFFSMDFK
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK057391 EMBL· GenBank· DDBJ | BAB71465.1 EMBL· GenBank· DDBJ | mRNA | ||
AK057523 EMBL· GenBank· DDBJ | BAB71520.1 EMBL· GenBank· DDBJ | mRNA | ||
AK292471 EMBL· GenBank· DDBJ | BAF85160.1 EMBL· GenBank· DDBJ | mRNA | ||
AL139109 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL627071 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL627390 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471132 EMBL· GenBank· DDBJ | EAX05331.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC036016 EMBL· GenBank· DDBJ | AAH36016.2 EMBL· GenBank· DDBJ | mRNA | ||
AF285594 EMBL· GenBank· DDBJ | AAK31973.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |