Q8IY34 · S15A3_HUMAN

  • Protein
    Solute carrier family 15 member 3
  • Gene
    SLC15A3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity).
Also able to transport carnosine (PubMed:31073693, PubMed:31254495).
Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity).

Catalytic activity

  • glycylglycylglycine(out) + n H+(out) = glycylglycylglycine(in) + n H+(in)
    This reaction proceeds in the forward direction.
  • carnosine(out) + n H+(out) = carnosine(in) + n H+(in)
    This reaction proceeds in the forward direction.
  • n H+(out) + L-histidine(out) = n H+(in) + L-histidine(in)
    This reaction proceeds in the forward direction.
  • n H+(out) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(out) = n H+(in) + N-acetyl-D-muramoyl-L-alanyl-D-isoglutamine(in)
    This reaction proceeds in the forward direction.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
428 μMglycyl-sarcosine
66.9 μML-histidine
5350 μMvalacyclovir
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
1860 pmol/min/mgtoward L-histidine
73.6 pmol/min/mgglycyl-sarcosine
63.7 pmol/min/mgvalacyclovir

pH Dependence

Optimum pH is 5.5.

GO annotations

AspectTerm
Cellular Componentendosome membrane
Cellular Componentintracellular membrane-bounded organelle
Cellular Componentlysosomal membrane
Molecular Functiondipeptide transmembrane transporter activity
Molecular Functionpeptide:proton symporter activity
Molecular Functionpeptidoglycan transmembrane transporter activity
Biological Processdipeptide import across plasma membrane
Biological Processinnate immune response
Biological Processmonoatomic ion transport
Biological Processpeptide transport
Biological Processpeptidoglycan transport
Biological Processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
Biological Processprotein transport

Keywords

Enzyme and pathway databases

Protein family/group databases

    • 2.A.17.3.9the proton-dependent oligopeptide transporter (pot/ptr) family

Names & Taxonomy

Protein names

  • Recommended name
    Solute carrier family 15 member 3
  • Alternative names
    • Osteoclast transporter
    • Peptide transporter 3
    • Peptide/histidine transporter 2
      (hPHT2
      )

Gene names

    • Name
      SLC15A3
    • Synonyms
      OCTP
      , PHT2
      , PTR3

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8IY34
  • Secondary accessions
    • Q9P2X9

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Multi-pass membrane protein
Endosome membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane38-58Helical
Transmembrane76-96Helical
Transmembrane103-123Helical
Transmembrane155-175Helical
Transmembrane200-220Helical
Transmembrane232-252Helical
Transmembrane310-330Helical
Transmembrane369-389Helical
Transmembrane411-431Helical
Transmembrane458-478Helical
Transmembrane497-517Helical
Transmembrane540-560Helical

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_034592349in dbSNP:rs17855607

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 680 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, glycosylation.

TypeIDPosition(s)Description
ChainPRO_00002959121-581Solute carrier family 15 member 3
Glycosylation61N-linked (GlcNAc...) asparagine
Glycosylation66N-linked (GlcNAc...) asparagine
Glycosylation178N-linked (GlcNAc...) asparagine
Glycosylation223N-linked (GlcNAc...) asparagine
Glycosylation356N-linked (GlcNAc...) asparagine
Glycosylation439N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-26Disordered

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    581
  • Mass (Da)
    63,560
  • Last updated
    2010-05-18 v2
  • Checksum
    56768D2963DB13D4
MPAPRAREQPRVPGERQPLLPRGARGPRRWRRAAGAAVLLVEMLERAAFFGVTANLVLYLNSTNFNWTGEQATRAALVFLGASYLLAPVGGWLADVYLGRYRAVALSLLLYLAASGLLPATAFPDGRSSFCGEMPASPLGPACPSAGCPRSSPSPYCAPVLYAGLLLLGLAASSVRSNLTSFGADQVMDLGRDATRRFFNWFYWSINLGAVLSLLVVAFIQQNISFLLGYSIPVGCVGLAFFIFLFATPVFITKPPMGSQVSSMLKLALQNCCPQLWQRHSARDRQCARVLADERSPQPGASPQEDIANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFPANPANISVALRAQGSSYTIPEAWLLLANVVVVLILVPLKDRLIDPLLLRCKLLPSALQKMALGMFFGFTSVIVAGVLEMERLHYIHHNETVSQQIGEVLYNAAPLSIWWQIPQYLLIGISEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSSLVALLSLPGGWLHCPKDFGNINNCRMDLYFFLLAGIQAVTALLFVWIAGRYERASQGPASHSRFSRDRG

Computationally mapped potential isoform sequences

There are 9 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
H0YFC1H0YFC1_HUMANSLC15A3247
H0YG40H0YG40_HUMANSLC15A3269
A0A7P0T8B5A0A7P0T8B5_HUMANSLC15A3579
A0A7P0T8H0A0A7P0T8H0_HUMANSLC15A3535
A0A7P0TAX8A0A7P0TAX8_HUMANSLC15A3527
A0A7P0Z4G8A0A7P0Z4G8_HUMANSLC15A3502
F5GZ36F5GZ36_HUMANSLC15A3448
F5H251F5H251_HUMANSLC15A3394
F5H1C8F5H1C8_HUMANSLC15A3456

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB020598
EMBL· GenBank· DDBJ
BAA93432.1
EMBL· GenBank· DDBJ
mRNA
AF135600
EMBL· GenBank· DDBJ
AAQ13565.1
EMBL· GenBank· DDBJ
mRNA
AP003721
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC037974
EMBL· GenBank· DDBJ
AAH37974.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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