Q8IX15 · HOMEZ_HUMAN

  • Protein
    Homeobox and leucine zipper protein Homez
  • Gene
    HOMEZ
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May function as a transcriptional regulator.

Caution

It is uncertain whether Met-1 or Met-25 is the initiator.

Features

Showing features for dna binding.

155050100150200250300350400450500550
TypeIDPosition(s)Description
DNA binding55-114Homeobox 1
DNA binding355-415Homeobox 2
DNA binding451-510Homeobox 3

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular Componentcytosol
Cellular Componentnucleolus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Homeobox and leucine zipper protein Homez
  • Alternative names
    • Homeodomain leucine zipper-containing factor

Gene names

    • Name
      HOMEZ
    • Synonyms
      KIAA1443

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q8IX15
  • Secondary accessions
    • A1L445
    • B4DZ80
    • F8WCA3
    • Q6P049
    • Q86XB6
    • Q9P2A5

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_055956278in dbSNP:rs10131813

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 588 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, cross-link, modified residue (large scale data), modified residue.

TypeIDPosition(s)SourceDescription
ChainPRO_00000491351-550UniProtHomeobox and leucine zipper protein Homez
Cross-link182UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link200UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Cross-link202UniProtGlycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)
Modified residue (large scale data)317PRIDEPhosphoserine
Modified residue351UniProtPhosphoserine
Modified residue (large scale data)351PRIDEPhosphoserine
Modified residue (large scale data)429PRIDEPhosphoserine
Modified residue (large scale data)437PRIDEPhosphothreonine
Modified residue (large scale data)444PRIDEPhosphoserine
Modified residue451UniProtPhosphothreonine
Modified residue (large scale data)451PRIDEPhosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Ubiquitous. Strongly expressed in adult testis and kidney as well as fetal lung and kidney.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer or heterodimer (Potential). Interacts with HOXC8.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
XENO Q8IX15rep PRO_0000449633 P0DTD14EBI-10742083, EBI-25492395
BINARY Q8IX15-3AEN Q8WTP83EBI-10172004, EBI-8637627
BINARY Q8IX15-3CENPS Q8N2Z93EBI-10172004, EBI-5529649
BINARY Q8IX15-3DEF6 Q9H4E73EBI-10172004, EBI-745369
BINARY Q8IX15-3DNTTIP1 Q9H1473EBI-10172004, EBI-2795449
BINARY Q8IX15-3EBF1 Q9UH733EBI-10172004, EBI-765426
BINARY Q8IX15-3EIF4E2 O605733EBI-10172004, EBI-398610
BINARY Q8IX15-3ELOA Q142413EBI-10172004, EBI-742350
BINARY Q8IX15-3GRB2 P629933EBI-10172004, EBI-401755
BINARY Q8IX15-3KPNA2 P522923EBI-10172004, EBI-349938
BINARY Q8IX15-3LNX1 Q8TBB13EBI-10172004, EBI-739832
BINARY Q8IX15-3LRRC7 A1L1C63EBI-10172004, EBI-10171988
BINARY Q8IX15-3MAD2L1BP Q150133EBI-10172004, EBI-712181
BINARY Q8IX15-3MED18 Q9BUE03EBI-10172004, EBI-394640
BINARY Q8IX15-3MRPL11 Q9Y3B73EBI-10172004, EBI-5453723
BINARY Q8IX15-3NCK2 O436393EBI-10172004, EBI-713635
BINARY Q8IX15-3PIN1 Q135263EBI-10172004, EBI-714158
BINARY Q8IX15-3PRKAA1 Q131313EBI-10172004, EBI-1181405
BINARY Q8IX15-3PRKAA2 P546463EBI-10172004, EBI-1383852
BINARY Q8IX15-3RBM39 Q14498-33EBI-10172004, EBI-6654703
BINARY Q8IX15-3RNF8 O760643EBI-10172004, EBI-373337
BINARY Q8IX15-3RPGR Q928343EBI-10172004, EBI-6558417
BINARY Q8IX15-3RPGR Q92834-63EBI-10172004, EBI-16431517
BINARY Q8IX15-3RPL9P9 P329693EBI-10172004, EBI-358122
BINARY Q8IX15-3SDCBP O005603EBI-10172004, EBI-727004
BINARY Q8IX15-3SH3RF2 Q08AM83EBI-10172004, EBI-10225873
BINARY Q8IX15-3SMYD1 Q8NB123EBI-10172004, EBI-8463848
BINARY Q8IX15-3SNRPB2 P085793EBI-10172004, EBI-1053651
BINARY Q8IX15-3SUMO2 P619563EBI-10172004, EBI-473220
BINARY Q8IX15-3TEAD4 Q155613EBI-10172004, EBI-747736
BINARY Q8IX15-3TLE5 Q081173EBI-10172004, EBI-717810
BINARY Q8IX15-3TRAF4 Q9BUZ43EBI-10172004, EBI-3650647
BINARY Q8IX15-3ZBTB7A O953653EBI-10172004, EBI-2795384

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region1-36Disordered
Region168-199Disordered
Compositional bias223-257Polar residues
Region223-265Disordered
Motif358-363Nuclear localization signal
Region424-465Disordered
Compositional bias451-465Pro residues
Region512-550Disordered

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8IX15-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    550
  • Mass (Da)
    61,240
  • Last updated
    2011-01-11 v2
  • Checksum
    A7DDF6DD56D8BDF0
MVRGWEPPPGLDCAISEGHKSEGTMPPNKEASGLSSSPAGLICLPPISEELQLVWTQAAQTSELDSNEHLLKTFSYFPYPSLADIALLCLRYGLQMEKVKTWFMAQRLRCGISWSSEEIEETRARVVYRRDQLHFKSLLSFTHHAGRPPEEVPPPPVPAPEQVGIGIGPPTLSKPTQTKGLKVEPEEPSQMPPLPQSHQKLKESLMTPGSGAFPYQSDFWQHLQSSGLSKEQAGRGPNQSHGIGTASWNHSTTVPQPQARDKPPPIALIASSCKEESASSVTPSSSSTSSSFQVLANGATAASKPLQPLGCVPQSVSPSEQALPPHLEPAWPQGLRHNSVPGRVGPTEYLSPDMQRQRKTKRKTKEQLAILKSFFLQCQWARREDYQKLEQITGLPRPEIIQWFGDTRYALKHGQLKWFRDNAVPGAPSFQDPAIPTPPPSTRSLNERAETPPLPIPPPPPDIQPLERYWAAHQQLRETDIPQLSQASRLSTQQVLDWFDSRLPQPAEVVVCLDEEEEEEEEELPEDDEEEEEEEEEDDDDDDDDVIIQD

Q8IX15-3

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-13: MVRGWEPPPGLDC → MLKSRISMRSRHPRR

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
U3KPW8U3KPW8_HUMANHOMEZ324
A0A669KB72A0A669KB72_HUMANHOMEZ439

Sequence caution

The sequence AAN76991.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.
The sequence BAA92681.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0543031-13in isoform 2
Compositional bias223-257Polar residues
Sequence conflict302in Ref. 5; AAI30393
Compositional bias451-465Pro residues
Sequence conflict529in Ref. 1; AAN76991, 2; BAA92681 and 5; AAI30393
Sequence conflict538in Ref. 5; AAI30393
Sequence conflict538in Ref. 3; BAG63992

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF463523
EMBL· GenBank· DDBJ
AAN76991.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AB037864
EMBL· GenBank· DDBJ
BAA92681.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK302788
EMBL· GenBank· DDBJ
BAG63992.1
EMBL· GenBank· DDBJ
mRNA
AL049829
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC130392
EMBL· GenBank· DDBJ
AAI30393.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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