Q8IVV8 · NKAI4_HUMAN

  • Protein
    Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4
  • Gene
    NKAIN4
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Variants

120820406080100120140160180200
GAVLISTCMDNEQRKHFYWPd*GAVLISTCMDNEQRKHFYWPd*
Variant
ID(s)
Position(s)ChangeDescriptionClinical
significance
Provenance
rs20670162683S>FEnsembl
rs10492539743S>PgnomAD
rs11564393294C>FgnomAD
rs11564393294C>YgnomAD
rs9956767955S>C1000Genomes
TOPMed
gnomAD
TCGA novel5S>F
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs20670160146G>DTOPMed
rs7465928426G>RExAC
TOPMed
gnomAD
rs7465928426G>SExAC
TOPMed
gnomAD
rs14629507427R>CTOPMed
gnomAD
rs8987071067R>HTOPMed
gnomAD
rs8987071067R>LTOPMed
gnomAD
TCGA novel9A>T
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
TCGA novel
rs2067015864
9A>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
TOPMed
rs124364864410L>FgnomAD
TCGA novel11V>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs206701564613L>FTOPMed
rs206701564613L>VTOPMed
rs160130733215A>TEnsembl
rs206701550816F>LEnsembl
TCGA novel17Q>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA
rs95437218218L>RTOPMed
gnomAD
rs119735335319V>IgnomAD
COSV10094162719V>L
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
rs136840113920A>DTOPMed
rs37050177820A>STOPMed
gnomAD
rs37050177820A>TTOPMed
gnomAD
rs77567000821A>TExAC
TOPMed
gnomAD
rs89535509224R>KTOPMed
gnomAD
rs76639651724R>SExAC
gnomAD
rs20056908926V>GExAC
gnomAD
rs103382906426V>MTOPMed
rs76863026527F>VExAC
gnomAD
rs206692870328D>ATOPMed
COSV10094167830L>P
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
rs206692858432Y>*TOPMed
gnomAD
TCGA novel32Y>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs206692849634W>*gnomAD
rs122733277334W>CTOPMed
gnomAD
rs119051795734W>GgnomAD
rs14560911135A>V1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs140155700236P>ATOPMed
gnomAD
rs140155700236P>STOPMed
gnomAD
rs117137948137I>VTOPMed
gnomAD
TCGA novel
rs745496327
38L>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
ExAC
TOPMed
gnomAD
rs74549632738L>VExAC
TOPMed
gnomAD
rs14034270039A>DVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs144804476040N>DTOPMed
gnomAD
rs144804476040N>HTOPMed
gnomAD
rs206692782642V>ATOPMed
gnomAD
rs206692785342V>IEnsembl
rs53059197243H>Y1000Genomes
ExAC
TOPMed
gnomAD
rs93999620144I>FTOPMed
rs93999620144I>VTOPMed
rs75663302745I>VExAC
gnomAD
rs75315966146I>TExAC
gnomAD
rs133993243246I>VgnomAD
COSV64786487
rs755318428
47V>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
ExAC
dbSNP
gnomAD
rs75196891649L>PExAC
gnomAD
rs93272252050G>EEnsembl
COSV6478533953G>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
rs14713755053G>S1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs75048439254T>AExAC
TOPMed
gnomAD
rs98997290254T>IEnsembl
rs75048439254T>PExAC
TOPMed
gnomAD
rs76524267656Q>*ExAC
TOPMed
gnomAD
rs20128582056Q>H1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs76059090956Q>RExAC
gnomAD
rs55344875158R>G1000Genomes
ExAC
TOPMed
gnomAD
rs20210912058R>QVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs55344875158R>W1000Genomes
ExAC
TOPMed
gnomAD
rs147223304059L>PgnomAD
rs57728502260R>C
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
Variant of uncertain significance (Ensembl)1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs74900932460R>HExAC
TOPMed
gnomAD
rs74900932460R>PExAC
TOPMed
gnomAD
rs92708161Y>*1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs143790265261Y>CgnomAD
rs206692640661Y>HTOPMed
rs76921754562V>IExAC
TOPMed
gnomAD
rs78152934663M>TExAC
gnomAD
rs74863806363M>VExAC
gnomAD
rs124701414964V>GgnomAD
rs212310721565Y>*Ensembl
rs76281807265Y>HExAC
gnomAD
COSV64785401
rs750271376
66T>Mcosmic curated
ExAC
TOPMed
gnomAD
rs212310715167L>VEnsembl
rs99900650268W>STOPMed
gnomAD
rs206690693869A>PgnomAD
TCGA novel70A>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs77594102670A>VExAC
gnomAD
rs11195471771V>IExAC
TOPMed
gnomAD
rs136392077872W>*gnomAD
rs77600288973V>IExAC
gnomAD
rs206690657674T>IEnsembl
COSV10094163975W>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs160129145876N>HEnsembl
rs77261919776N>KExAC
TOPMed
gnomAD
COSV6478470076N>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs15073736877V>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs36930274778F>SVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs14126453979I>VVariant of uncertain significance (Ensembl)ESP
ExAC
TOPMed
gnomAD
rs74953898381C>RExAC
TOPMed
gnomAD
rs212310670782F>CEnsembl
COSV6478605882F>V
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs124770751483Y>CgnomAD
rs124770751483Y>SgnomAD
rs118688922784L>QgnomAD
rs86715067285E>KgnomAD
rs56517215487G>R1000Genomes
ExAC
TOPMed
gnomAD
COSV64786751
rs565172154
87G>Scosmic curated
1000Genomes
ExAC
TOPMed
gnomAD
rs14265748488G>CESP
ExAC
TOPMed
gnomAD
rs14265748488G>SESP
ExAC
TOPMed
gnomAD
COSV64784830
rs201793448
89L>F
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
1000Genomes
ExAC
TOPMed
dbSNP
gnomAD
rs112965991K>*1000Genomes
ESP
ExAC
TOPMed
gnomAD
VAR_037051
COSV64785768
rs1129659
91K>QUniProt
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs14892229292D>NVariant of uncertain significance (Ensembl)ESP
TOPMed
gnomAD
rs94661530093S>GEnsembl
rs116432480593S>RTOPMed
gnomAD
rs149026127194E>GEnsembl
rs75820833594E>KExAC
TOPMed
gnomAD
rs75820833594E>QExAC
TOPMed
gnomAD
rs206688758797T>IEnsembl
rs141020832898F>CgnomAD
rs141020832898F>SgnomAD
rs55262966599S>REnsembl
COSV99059107
rs1482984117
101S>Fcosmic curated
TOPMed
gnomAD
rs1013705958101S>PTOPMed
rs987782647102R>GTOPMed
gnomAD
rs778530273102R>QExAC
TOPMed
gnomAD
rs987782647102R>WTOPMed
gnomAD
rs1489006197103H>RgnomAD
rs2066887100103H>YgnomAD
rs138818067104R>C1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs927666296104R>HTOPMed
gnomAD
rs753628332105S>AExAC
gnomAD
rs888032938106W>*TOPMed
gnomAD
rs766062224108R>CTOPMed
gnomAD
rs980921395108R>HTOPMed
gnomAD
rs980921395108R>LTOPMed
gnomAD
rs980921395108R>PTOPMed
gnomAD
rs11906010109E>DVariant of uncertain significance (Ensembl)1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSV64785360
rs773767863
110R>Ccosmic curated
TOPMed
gnomAD
rs76984019110R>H1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSV99059104
rs76984019
110R>Lcosmic curated
1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs770063674111W>*ExAC
TOPMed
gnomAD
rs1170204174112P>AgnomAD
rs759894824113G>SExAC
gnomAD
rs2066886068115L>PEnsembl
rs1358986581116H>PTOPMed
gnomAD
rs1159919664117E>*TOPMed
gnomAD
rs1159919664117E>KTOPMed
gnomAD
rs1036730371117E>VTOPMed
rs1472303147118E>*TOPMed
gnomAD
rs2066885595118E>AEnsembl
rs1472303147118E>KTOPMed
gnomAD
rs2066885595118E>VEnsembl
rs1601287867119V>GEnsembl
rs746602438119V>MEnsembl
rs952266704120P>LEnsembl
rs555212860121A>T1000Genomes
ExAC
gnomAD
rs2066885212122V>MEnsembl
TCGA novel123G>R
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs1434162368123G>VgnomAD
rs943827519124L>FTOPMed
rs2123097439124L>REnsembl
rs763343250125G>RVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs773778167125G>VExAC
gnomAD
rs763343250125G>WVariant of uncertain significance (Ensembl)ExAC
TOPMed
gnomAD
rs566900551126A>DVariant of uncertain significance (Ensembl)1000Genomes
ExAC
TOPMed
gnomAD
COSV64784949
rs770126206
126A>Pcosmic curated
ExAC
gnomAD
rs566900551126A>VVariant of uncertain significance (Ensembl)1000Genomes
ExAC
TOPMed
gnomAD
rs1019027705127P>SEnsembl
rs2066884562128H>REnsembl
rs1326446814130Q>LgnomAD
VAR_037052
COSV64785391
rs2236194
131A>DUniProt
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs2236194131A>G1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSV64785451131A>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs2066884418131A>TgnomAD
rs1405066828132L>PTOPMed
rs1405066828132L>QTOPMed
rs1334492401135G>ATOPMed
gnomAD
rs1334492401135G>DTOPMed
gnomAD
rs1233842365135G>RTOPMed
gnomAD
rs1233842365135G>STOPMed
gnomAD
rs1334492401135G>VTOPMed
gnomAD
rs1330331227137G>SgnomAD
rs200873761139A>V1000Genomes
ExAC
TOPMed
gnomAD
rs1280432753140L>PTOPMed
gnomAD
rs2066883721141E>DTOPMed
rs1367703395142P>HgnomAD
TCGA novel142P>S
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs778884781144Y>HExAC
gnomAD
rs2066883597144Y>SEnsembl
rs1386508946145V>LTOPMed
gnomAD
rs1386508946145V>MTOPMed
gnomAD
rs1568708090147A>DEnsembl
COSV64787628
rs1256223155
147A>Tcosmic curated
gnomAD
rs1466958421148L>PgnomAD
rs1174863559148L>VTOPMed
gnomAD
rs1377434869149H>NgnomAD
VAR_037053
COSV64785053
rs872808
151C>GUniProt
cosmic curated
1000Genomes
ESP
ExAC
TOPMed
dbSNP
gnomAD
rs872808151C>R1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs872808151C>S1000Genomes
ESP
ExAC
TOPMed
gnomAD
COSV100941631
rs1248318710
151C>Ycosmic curated
TOPMed
gnomAD
rs1463191489152L>PTOPMed
gnomAD
rs1277427818153Q>HgnomAD
rs1200979348154I>FgnomAD
rs946673985156I>MTOPMed
gnomAD
TCGA novel157A>=
Variant assessed as Somatic; LOW impact. (NCI-TCGA)
NCI-TCGA
rs1052109367157A>ETOPMed
gnomAD
rs201902703157A>S1000Genomes
ExAC
TOPMed
gnomAD
rs201902703157A>T1000Genomes
ExAC
TOPMed
gnomAD
rs1052109367157A>VTOPMed
gnomAD
rs1249528709158L>VTOPMed
rs768363146161F>SExAC
gnomAD
rs1311318985162V>DgnomAD
rs1321817791162V>FTOPMed
gnomAD
rs1231388302163C>SVariant of uncertain significance (Ensembl)TOPMed
gnomAD
rs2066811764166Q>*Ensembl
rs1288898886166Q>HTOPMed
gnomAD
rs1601276957167V>GEnsembl
rs112977482168V>AEnsembl
COSV53901173
rs573831787
169S>Rcosmic curated
1000Genomes
ExAC
TOPMed
gnomAD
COSV53901057
rs745364728
170V>M
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
ExAC
TOPMed
dbSNP
gnomAD
COSV53901424
rs141841184
172T>MVariant of uncertain significance (Ensembl)cosmic curated
ESP
ExAC
TOPMed
gnomAD
VAR_037054
rs11556207
173E>D
UniProt
Ensembl
dbSNP
rs780536321173E>GgnomAD
rs780536321173E>VgnomAD
rs555765679174E>K1000Genomes
ExAC
TOPMed
gnomAD
rs533912810175E>D1000Genomes
ExAC
gnomAD
rs1601276839175E>KEnsembl
COSV53903459176D>N
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs201583735177S>N1000Genomes
ExAC
TOPMed
gnomAD
rs200940789178F>L1000Genomes
ExAC
gnomAD
rs758385036179D>YExAC
gnomAD
rs2066776487180F>CTOPMed
gnomAD
TCGA novel180F>L
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA
rs2066776487180F>STOPMed
gnomAD
rs376587085181I>MESP
TOPMed
gnomAD
rs535399604181I>TVariant of uncertain significance (Ensembl)1000Genomes
ExAC
COSV99416797
rs1438919798
185D>Vcosmic curated
gnomAD
rs760720826186P>QExAC
TOPMed
gnomAD
rs2066776162186P>STOPMed
rs2123050880187F>L1000Genomes
rs2066776095187F>SEnsembl
rs80100531188P>L1000Genomes
ESP
ExAC
TOPMed
gnomAD
rs752484769188P>SExAC
gnomAD
rs1305092202190Y>CTOPMed
gnomAD
rs759225370190Y>HExAC
TOPMed
gnomAD
TCGA novel190Y>P
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA
rs2123050687191H>REnsembl
COSV99416987191H>Y
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs2066775578192V>DTOPMed
rs770669548193N>SExAC
TOPMed
gnomAD
COSV105091380
rs1450879995
197S>Fcosmic curated
TOPMed
gnomAD
COSV53901394
rs762342864
197S>Pcosmic curated
ExAC
gnomAD
rs762342864197S>TExAC
gnomAD
rs772849486198S>NExAC
gnomAD
COSV53900801
COSV53900801,COSV99416874
COSV99416874
199L>F
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
COSV53900801
COSV53900801,COSV99416874
COSV99416874
199L>I
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1187458155200L>SgnomAD
rs748691145202K>EExAC
TOPMed
gnomAD
rs748691145202K>QExAC
TOPMed
gnomAD
rs1258237902202K>RgnomAD
rs1313538380203Q>ETOPMed
rs781492419203Q>HExAC
TOPMed
gnomAD
rs2123050258204V>AEnsembl
rs769026539204V>LExAC
TOPMed
gnomAD
rs769026539204V>MExAC
TOPMed
gnomAD
COSV99416515205Y>*
Variant assessed as Somatic; HIGH impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs747422095205Y>FExAC
gnomAD
rs2123041054207P>HEnsembl
COSV99417017207P>L
Variant assessed as Somatic; MODERATE impact. (NCI-TCGA)
NCI-TCGA Cosmic
cosmic curated
rs1233052054207P>STOPMed
gnomAD
rs1233052054207P>TTOPMed
gnomAD
rs750109793208A>VVariant of uncertain significance (Ensembl)ExAC
gnomAD
rs1294518604209*>=gnomAD
rs1435178671209*>LTOPMed
gnomAD
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