this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3 but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.
Finally downregulation of hvrk3 using siRNA reduced the amplitude and lengthened the period of the cellular bioluminescence rhythm. Taken together these data suggest that VRK3 plays a role in setting the amplitude and period length of circadian rhythms in mammalian cells.
Data from molecular dynamic simulations suggest that bivalent cations play key structural roles in stabilization of VRK1/VRK2; bivalent cations have no obvious effects on VRK3. These kinases are targets in search for antineoplastic agents. (review)
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