Q8IS19 · GEFD_DICDI

Function

function

Promotes the exchange of Ras-bound GDP by GTP.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular FunctionGTPase activator activity
Molecular Functionguanyl-nucleotide exchange factor activity
Biological ProcessRas protein signal transduction
Biological Processresponse to differentiation-inducing factor 1

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras guanine nucleotide exchange factor D
  • Alternative names
    • RhoGAP domain-containing protein D

Gene names

    • Name
      gefD
    • Synonyms
      RasGEFD
    • ORF names
      DDB_G0289667

Organism names

Accessions

  • Primary accession
    Q8IS19
  • Secondary accessions
    • Q54H48

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003844621-668Ras guanine nucleotide exchange factor D

Proteomic databases

Expression

Developmental stage

Expressed during development; especially between 8 and 12 hours of development.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-224Rho-GAP
Domain237-362N-terminal Ras-GEF
Domain433-663Ras-GEF

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    668
  • Mass (Da)
    77,224
  • Last updated
    2003-03-01 v1
  • Checksum
    5858EFBC6C38D28B
MGNSKQIKRSLTGSILLKKQISQIFFKKLESIFGIALAEDTSDRLMDYLNKSIDYLLDHSVIEGLFSIEIEESKLKSTIESIESTLITDFSLTTDPCYVASTFILYFSKLPNLLLSKISSQLIHSVEISHEEYRINVIRSLLYSLPLQNRNILKMVLHFLKKFSLACNNNNNNNSENNNTIVEDIEVQSAYNRFTKAFMSTTPGNFEISCKAIRLMVMDIDEFDKLPQDIQYMVKDGESIVKAATFDRLVEKLFDLSYGFKDPDYNYTVFHTYDYYTTSVELLGKIVHYYRIACTLTTKLQMEVSITILSVAMFWMKIHHNHLMTDLQFLQKLKIFLDSVPQVPPTQVTYFTYFQTFFKPVIEPLKPLYERGNSFLGPNLTQSSGTSKKKNQLIEKMMINNNINNNNNINNNVNSNSNNNFNNNIDIDIYNIGSNIIAQQITIIDNEMLMAIPPSQFLHKSFSKESKSPQFHDMVSKFNEWARWTSSEILSKEKLVERVVTLSFFIDLAKSCVELGNYNAANAIVGGLNHSSISRLKLTWERLSTKVTQDYDRLLSLFDLSMNYKNYRDEIKSTKAKIIPYLGLFPKDLIAIEEGNDNFTNNNLINTEKFRLLYQTIKKIQSYQQPLFTFKTSEPIKQYLKNISNGLSEEKDFHSISHKLEPRQQQTQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY160093
EMBL· GenBank· DDBJ
AAN46873.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000148
EMBL· GenBank· DDBJ
EAL62545.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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