Q8IS12 · GEFN_DICDI

Function

function

Promotes the exchange of Ras-bound GDP by GTP (By similarity).
May play a role in chemotaxis

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionguanyl-nucleotide exchange factor activity
Biological ProcessRas protein signal transduction
Biological Processresponse to differentiation-inducing factor 1

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ras guanine nucleotide exchange factor N
  • Alternative names
    • RasGEF domain-containing protein N

Gene names

    • Name
      gefN
    • Synonyms
      rasGEFN
    • ORF names
      DDB_G0275703

Organism names

Accessions

  • Primary accession
    Q8IS12
  • Secondary accessions
    • Q553C1
    • Q869N0

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003844721-1138Ras guanine nucleotide exchange factor N

Proteomic databases

Expression

Developmental stage

Expressed during development; with a peak at 12 hours.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for repeat, region, compositional bias, domain.

Type
IDPosition(s)Description
Repeat1-16LRR 1
Repeat18-39LRR 2
Repeat43-64LRR 3
Region126-180Disordered
Compositional bias142-162Polar residues
Region239-301Disordered
Region319-360Disordered
Region389-411Disordered
Region473-540Disordered
Compositional bias484-499Pro residues
Compositional bias500-540Polar residues
Region601-643Disordered
Region660-680Disordered
Domain733-855N-terminal Ras-GEF
Domain891-1118Ras-GEF

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,138
  • Mass (Da)
    125,574
  • Last updated
    2003-03-01 v1
  • Checksum
    D07BC283C05D10EF
MSYNSLTTIDIDITQLLHLKSVNLRSNKLGNSSGVSYFGSMDTLQKLNLKENYLTELPSTFYLLKLSSLKLDTFTPLYQQQQQQQNQLQRPIINSQSTSNESLIHEINRSFENLSMSEPVSPRIAALKNEKKGPPKPLPKTKGLHSSSSNINTSNNITPILMSPIHDGNKKSPSIISNNNNNNNSNSNIITSNGTVIPQLVFKNEPTGGRLRSFTLDADHISPGRELVSTGSSDEILYFNSEGGCENSDSDEPIQPLSAGRSRAQTISGKQPSIINNNNNNNSGGGSGNNNNSGGGGGSRKAFQNLIKSAKQIGSNIKNKTHHINGHSSSSQSNSTTNTPSISSTPYPTSTIKTNVSDTNTPVNYNGQQQISKVIQRVSGEIDPLYSGIDSPRTLERRNSSRDDIPISPPQGCMTPIKRLGSVEGDEISAIFSSSTDANMDVSQDYSSSTPTVNSMSYQSSFLDTFDNQSTVGSPTFYQLPVSSQPPQHPPPPPPIKDNNQPKLNQSQNLINTNSNSVTTTNNSSQTTTTTTTTTTNNNNVLNLEKLHKLDFAEDINGDERCSNPLYSKKKLAGLLFPNKHHQPSALKTAKIRFKSSKRLATTVNSNSSNNLMMSNSPLSSSSMNLLQQSNSPQYSGTPTSGSFQNQSVLSATLMSSPSMSDVFSGGNSQGGGSSLSQSGSITPVAPLSAVQGSPIGNSGSVNNIYLEGDDFIRDLMQSPIINQEIEFTSEDGVPKVKNITLKMLTSLLTHEKGQSNELNGIFFDTYLLFTSIPLVIEHLESRFLNGKNHIVKQKVITFSQKWVEVCWSDFKEEHIELLLKFLNDCSEQIEKLVTGSFALRTSLNLLLNIINMKRDGTYITEEEETFEQPAPIPDFIQLPNCVDINLMDLRPHEIARQLTILDHELLTQITKQQMLDYAVHQTNSPSIVKVTDRFNYLVLWVSTEIVLSLTIEKRIETIFKFVNIALNCWYLKNFNSAIAIIAAMSKPSIEKLKQTWGFIRNTKANAPIQELKELILPTNVARLRKIMDSVEAPFIPYLGAYFSHSIAIHAGNKSIVNEQYINMQKYDMMGKIIRSITVAQEKKYNLTPVGVLQKFLTDSFVLTEKQLYSEASKIEEKGDSYITETTKFGSIFKKKDK

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias142-162Polar residues
Compositional bias484-499Pro residues
Compositional bias500-540Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY160103
EMBL· GenBank· DDBJ
AAN46883.1
EMBL· GenBank· DDBJ
Genomic DNA
AAFI02000013
EMBL· GenBank· DDBJ
EAL69602.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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