Q8IPX7 · EXOS3_DROME

Function

function

Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (By similarity).
In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts such as antisense RNA species, and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm (By similarity).
In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs (By similarity).
The catalytic inactive RNA exosome core complex of 9 subunits is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes (By similarity).
Required generally for normal embryonic and neuronal development (PubMed:32645003).
Also plays a critical role in the maintenance of neuronal function in mature flies by controlling the levels of specific mRNAs such as the synaptic regulator Arc1 (PubMed:32645003).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytoplasmic exosome (RNase complex)
Cellular Componentexosome (RNase complex)
Cellular Componentnuclear exosome (RNase complex)
Cellular Componentnucleolus
Molecular FunctionRNA binding
Biological Processbrain development
Biological ProcessCUT catabolic process
Biological Processexonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Biological Processlarval lymph gland hemopoiesis
Biological Processmushroom body development
Biological Processnuclear polyadenylation-dependent rRNA catabolic process
Biological Processnuclear-transcribed mRNA catabolic process
Biological Processnuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Biological Processpoly(A)-dependent snoRNA 3'-end processing
Biological Processregulation of embryonic development
Biological Processregulation of gene expression
Biological ProcessTRAMP-dependent tRNA surveillance pathway
Biological ProcessU4 snRNA 3'-end processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Exosome complex component RRP40
  • Alternative names
    • Ribosomal RNA-processing protein 40

Gene names

    • Name
      Rrp40
    • ORF names
      CG31938

Organism names

  • Taxonomic identifier
  • Strain
    • Berkeley
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora

Accessions

  • Primary accession
    Q8IPX7

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown in the whole body, neurons, glia or muscles is lethal (PubMed:32645003).
RNAi-mediated knockdown in mushroom bodies affects the morphology of the alpha- and beta-lobes as well as ellipsoid bodies (PubMed:32645003).
RNAi-mediated knockdown in the wing pouch results in severe wing development phenotypes and increase of miR-252-5p expression (PubMed:25892215).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis11Results in reduced viability, shortened lifespan, age-dependent wing posture and locomotor defects. Shows a mushroom body beta-lobe midline-crossing defect. Results in increased steady-state levels of specific neuronal mRNAs such as Arc1 and wfs1.
Mutagenesis87Results in reduced viability, shortened lifespan, age-dependent wing posture and locomotor defects. Results in increased steady-state levels of specific neuronal mRNAs such as Arc1 and wfs1.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004514581-232Exosome complex component RRP40

Proteomic databases

Expression

Gene expression databases

    • FBgn0260648Expressed in eye disc (Drosophila) and 21 other cell types or tissues

Interaction

Subunit

Component of the RNA exosome complex (PubMed:12490954).
Specifically part of the catalytically inactive RNA exosome core complex (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q8IPX7Rrp46 Q9VGZ24EBI-106288, EBI-166198

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the RRP40 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    232
  • Mass (Da)
    25,026
  • Last updated
    2003-03-01 v1
  • Checksum
    5CCAB9DEECD84C7F
MSATSTIVMPGERIAAIEELAKSKRVILGPGLRRLDDTVVASKAGPLRHKEPGTFWVDNYQRRYIPARGDLILGIVRAKAGDLYRVDIGATDTASISYLAFEAASKKNRPDLIPGDLIYARVLNASADIEPELVCVNSVGKSGKLGVLTDGFFFKCSLNLGRMLLRENCPVLAALTRELPYEIAVGVNGRIWLKAHSLKETVALANAISALEQSGCAEIDKICGNLGDFLQA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE014134
EMBL· GenBank· DDBJ
AAN10459.1
EMBL· GenBank· DDBJ
Genomic DNA
AE014134
EMBL· GenBank· DDBJ
AHN54080.1
EMBL· GenBank· DDBJ
Genomic DNA
BT023807
EMBL· GenBank· DDBJ
AAZ66314.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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