Q8IMW2 · Q8IMW2_DROME
- Proteinubiquitinyl hydrolase 1
- Genepuf
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids3912 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
Catalytic activity
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | cysteine-type deubiquitinase activity | |
Biological Process | positive regulation of cell growth | |
Biological Process | post-translational protein modification | |
Biological Process | protein deubiquitination | |
Biological Process | regulation of protein stability | |
Biological Process | wing disc development |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameubiquitinyl hydrolase 1
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8IMW2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 101-172 | Disordered | ||||
Sequence: AQQQREQQRDEASAQAEAKESSAPAEEPKKEEPSGSAGEEAQGSGDGPAKKPPVGPCTPPPPQTANPQHKSH | ||||||
Compositional bias | 110-136 | Basic and acidic residues | ||||
Sequence: DEASAQAEAKESSAPAEEPKKEEPSGS | ||||||
Compositional bias | 152-166 | Pro residues | ||||
Sequence: PPVGPCTPPPPQTAN | ||||||
Region | 518-590 | Disordered | ||||
Sequence: NVTASSSDSGSIEGSNTEDDHVGADDSSIASGGGGGGVGNKSPIDGVTPCKQARHRRHICDPTTEKGKQISPE | ||||||
Compositional bias | 567-590 | Basic and acidic residues | ||||
Sequence: CKQARHRRHICDPTTEKGKQISPE | ||||||
Compositional bias | 660-683 | Acidic residues | ||||
Sequence: DVPSSDEADGEADGDGEGELLADS | ||||||
Region | 660-688 | Disordered | ||||
Sequence: DVPSSDEADGEADGDGEGELLADSDECSD | ||||||
Region | 851-878 | Disordered | ||||
Sequence: VVSGGKQHHSPKASQGSSTSGSTPVQPS | ||||||
Compositional bias | 858-878 | Polar residues | ||||
Sequence: HHSPKASQGSSTSGSTPVQPS | ||||||
Compositional bias | 1491-1511 | Polar residues | ||||
Sequence: SRRGESNGNVAMGNTPEQVRV | ||||||
Region | 1491-1611 | Disordered | ||||
Sequence: SRRGESNGNVAMGNTPEQVRVKKSSMGRRRNSNEQPPPPPPEVKMSKEQLCELEAPLTPTPSTGLQDVETEASSSSGGDKENQPKQHSKRQKKGETFEQEKERPVGCSTPPSPTPPPPALS | ||||||
Compositional bias | 1549-1571 | Polar residues | ||||
Sequence: PTPSTGLQDVETEASSSSGGDKE | ||||||
Compositional bias | 1572-1592 | Basic and acidic residues | ||||
Sequence: NQPKQHSKRQKKGETFEQEKE | ||||||
Domain | 2015-2380 | USP | ||||
Sequence: VGLTNLGATCYMASCVQHLYMMPQARAAVLRVPPNAARKHGPTLLELQRMFAYLLESERKSYNPRSFCRVYQMDHQPLNTGEQKDMAEFFIDLVSKLEDMTPDLKHLVKRLFCGSLSNNVVSLDCGHVSRTAEDFYTVRCQVADMRNLQESLDEVTVKDTLEGDNMYTCSQCGKKVRAEKRACFKKLPQILCFNTMRYTFNMVTMLKEKVNTHFSFPLRLNMCHYVEKTLMPQQYKEERERRQKEKEGADGSGDGNDNEKAEATLDDDIEECYEYELVGVTVHTGTADGGHYYSFIKERTKTSYHTHERWFLFNDAEVKPFDPSQIAAECFGGEMTSKTYDSVTEKYLDFSFEKTNSAYMLFYERR | ||||||
Region | 2249-2274 | Disordered | ||||
Sequence: YKEERERRQKEKEGADGSGDGNDNEK | ||||||
Region | 2391-2529 | Disordered | ||||
Sequence: ELLVTPTPSPTVEEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDEKPTEMTTVSTEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKA | ||||||
Compositional bias | 2403-2493 | Basic and acidic residues | ||||
Sequence: EEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDEKPTEMTTV | ||||||
Compositional bias | 2494-2529 | Polar residues | ||||
Sequence: STEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKA | ||||||
Coiled coil | 3295-3322 | |||||
Sequence: QKKQQQQQQQLEQQLQLQQQQMLQKQQQ | ||||||
Region | 3322-3344 | Disordered | ||||
Sequence: QQSQSQTQTPQSPQQKEKQLQQQ | ||||||
Compositional bias | 3657-3701 | Basic and acidic residues | ||||
Sequence: SERFRKESERDPFPNKKQKRDSQKIKEKEHPQPESEKETSTENDK | ||||||
Region | 3657-3776 | Disordered | ||||
Sequence: SERFRKESERDPFPNKKQKRDSQKIKEKEHPQPESEKETSTENDKPSDVSMESSGNAEQATDSTKPPTPAGSDDEQMDKTSVPSSDDETELEDELQPTPKRNKKASNKKTAQDRVNEERE | ||||||
Compositional bias | 3702-3734 | Polar residues | ||||
Sequence: PSDVSMESSGNAEQATDSTKPPTPAGSDDEQMD | ||||||
Compositional bias | 3750-3776 | Basic and acidic residues | ||||
Sequence: ELQPTPKRNKKASNKKTAQDRVNEERE | ||||||
Region | 3800-3912 | Disordered | ||||
Sequence: ASVPSSGATKEPSEEPCGEASTSAAAAVKLSRPKGACTPPEPITDVNDTRCNIDTETEAEADEQSPKTSQTNGSQQNESPPAATSADTAPANPSPAPAAAVASTSQAASPTQI | ||||||
Compositional bias | 3863-3890 | Polar residues | ||||
Sequence: QSPKTSQTNGSQQNESPPAATSADTAPA | ||||||
Compositional bias | 3897-3912 | Polar residues | ||||
Sequence: AAAVASTSQAASPTQI |
Sequence similarities
Belongs to the peptidase C19 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length3,912
- Mass (Da)440,388
- Last updated2015-04-01 v2
- ChecksumBD80DDFE8D04291F
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q9VC56 | PUF_DROME | puf | 3912 | ||
A0A0B4LIK5 | A0A0B4LIK5_DROME | puf | 3921 | ||
A0A0B4KHF3 | A0A0B4KHF3_DROME | puf | 3921 | ||
A0A0B4KI06 | A0A0B4KI06_DROME | puf | 3930 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 110-136 | Basic and acidic residues | ||||
Sequence: DEASAQAEAKESSAPAEEPKKEEPSGS | ||||||
Compositional bias | 152-166 | Pro residues | ||||
Sequence: PPVGPCTPPPPQTAN | ||||||
Compositional bias | 567-590 | Basic and acidic residues | ||||
Sequence: CKQARHRRHICDPTTEKGKQISPE | ||||||
Compositional bias | 660-683 | Acidic residues | ||||
Sequence: DVPSSDEADGEADGDGEGELLADS | ||||||
Compositional bias | 858-878 | Polar residues | ||||
Sequence: HHSPKASQGSSTSGSTPVQPS | ||||||
Compositional bias | 1491-1511 | Polar residues | ||||
Sequence: SRRGESNGNVAMGNTPEQVRV | ||||||
Compositional bias | 1549-1571 | Polar residues | ||||
Sequence: PTPSTGLQDVETEASSSSGGDKE | ||||||
Compositional bias | 1572-1592 | Basic and acidic residues | ||||
Sequence: NQPKQHSKRQKKGETFEQEKE | ||||||
Compositional bias | 2403-2493 | Basic and acidic residues | ||||
Sequence: EEKSEAEEPTKMETSSSEIKADVDVEVEVEEKDKEKPAQTDTESKETPAKEEIADDKSKQDEPEEKKIEKQSREGEEKSETDEKPTEMTTV | ||||||
Compositional bias | 2494-2529 | Polar residues | ||||
Sequence: STEEEKQPTANCDNHQQNNNSNSKASNDQQPSTSKA | ||||||
Compositional bias | 3657-3701 | Basic and acidic residues | ||||
Sequence: SERFRKESERDPFPNKKQKRDSQKIKEKEHPQPESEKETSTENDK | ||||||
Compositional bias | 3702-3734 | Polar residues | ||||
Sequence: PSDVSMESSGNAEQATDSTKPPTPAGSDDEQMD | ||||||
Compositional bias | 3750-3776 | Basic and acidic residues | ||||
Sequence: ELQPTPKRNKKASNKKTAQDRVNEERE | ||||||
Compositional bias | 3863-3890 | Polar residues | ||||
Sequence: QSPKTSQTNGSQQNESPPAATSADTAPA | ||||||
Compositional bias | 3897-3912 | Polar residues | ||||
Sequence: AAAVASTSQAASPTQI |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE014297 EMBL· GenBank· DDBJ | AAN14009.2 EMBL· GenBank· DDBJ | Genomic DNA |