Q8ILP3 · P113_PLAF7
- ProteinSurface protein P113
- GeneP113
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids969 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Membrane receptor which tethers secreted RH5 to the merozoite membrane during merozoite invasion of host erythocytes.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Cellular Component | symbiont-containing vacuole membrane |
Names & Taxonomy
Protein names
- Recommended nameSurface protein P113
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionQ8ILP3
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, glycosylation, modified residue (large scale data), lipidation, propeptide.
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Signal | 1-22 | UniProt | |||||
Sequence: MKIPFFILHILLLQFLLCLIRC | |||||||
Chain | PRO_5019107734 | 23-945 | UniProt | Surface protein P113 | |||
Sequence: YVHNDVIKFGEENSLKCSQGNLYVLHCEVQCLNGNNEIIHKRCNDDIEKKCNGNNKCIYFFEYELRKKTQSFRNKNSIEISECVESEQNEVKTSTTCLLSNSFILDEAFIQYFFFIKNKNEEPVICKDGNINIKSALLHSPFCEIKLKDISEYIRKKCDNNKECLIDPLDVQKNLLNEEDPCYINNSYVSVNVVCNKEEEIGDESTDSSSMEIQDSTSNEQDENVKGMSSSQEMNSNNDENKNQDNESDDDVNNNNNNNNDDQDEQGNDGDVTSSMNKNEDNKDLEHGSSNDVNNNTDTLVNNKENKEFVLKEKSSLTSKINKELAHRTALFNKLADNISLLLNKKYDSFEIKDVLEDRYNEMKRDANPDVYYIYLMDTLDIEKIEDINLEEVKMSLLASLKETMNKIDTIEKKIEEFKNKYISLYNKVKTTMPELFDLNEDLVLLYNDFPFDNGMISSDIFFKYNPSENIMDHQEMVKKGSITEDELRIVNDLEPLDNYRRRKRITELRKILVEKLRILYLEKNNLFNTQASCIKSYCYKNPLNLKTLEVLLKKNYYRLKENKDYDVVSSIIQHLDNVDANKKKKWLTHERILKKLQVLIAEGYKRINEKEKDIDRRMAVYNALYEKAQSYNLQKLFNDSNDFLKKYAIMGNSFDDGDEVFGSQSSNFNIFDSNNTDQNNEQEQPKQDDQLLNNNNDDVLSESNNENKEKTSDDATHKETQEKSDQEPSQNIQEDNSDEKHAENEENVEQIETDSNVSEEANDENKDNMQTTTDEGTEELQQNDEDAESLTKENSKSEEQENEDSTDAEAIDKEEVETEEKGKDEQKKDEQKEQDEEEDGEKENKHKSSETTNETVTDIEENKNEVKGEEHLQGSEQSIEASESSQKDETKETEDKEEYVNANDDESSEEDTTPNETNKTDN | |||||||
Glycosylation | 207 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 268 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 317 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 360 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 504 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 661 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 697 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 776 | PTMeXchange | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 778 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 779 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 781 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 812 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 818 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 820 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 828 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 829 | PTMeXchange | Phosphothreonine | ||||
Sequence: T | |||||||
Glycosylation | 876 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Modified residue (large scale data) | 880 | PTMeXchange | Phosphothreonine | ||||
Sequence: T | |||||||
Modified residue (large scale data) | 901 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 930 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Glycosylation | 938 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Glycosylation | 941 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Lipidation | 945 | UniProt | GPI-anchor amidated asparagine | ||||
Sequence: N | |||||||
Glycosylation | 945 | UniProt | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | |||||||
Propeptide | PRO_0000448667 | 946-969 | UniProt | Removed in mature form | |||
Sequence: GSSFFFAMSNALLVILLLLFIEFL |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Developmental stage
Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).
Interaction
Subunit
Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186).
Within the complex, interacts with RH5 (via N-terminus); the interaction tethers RH5 to the merozoite membrane (PubMed:28186186).
Within the complex, interacts with RH5 (via N-terminus); the interaction tethers RH5 to the merozoite membrane (PubMed:28186186).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 223-328 | Disordered | ||||
Sequence: IGDESTDSSSMEIQDSTSNEQDENVKGMSSSQEMNSNNDENKNQDNESDDDVNNNNNNNNDDQDEQGNDGDVTSSMNKNEDNKDLEHGSSNDVNNNTDTLVNNKEN | ||||||
Compositional bias | 229-261 | Polar residues | ||||
Sequence: DSSSMEIQDSTSNEQDENVKGMSSSQEMNSNND | ||||||
Compositional bias | 272-297 | Polar residues | ||||
Sequence: DDVNNNNNNNNDDQDEQGNDGDVTSS | ||||||
Compositional bias | 311-326 | Polar residues | ||||
Sequence: SSNDVNNNTDTLVNNK | ||||||
Compositional bias | 688-724 | Polar residues | ||||
Sequence: SSNFNIFDSNNTDQNNEQEQPKQDDQLLNNNNDDVLS | ||||||
Region | 688-947 | Disordered | ||||
Sequence: SSNFNIFDSNNTDQNNEQEQPKQDDQLLNNNNDDVLSESNNENKEKTSDDATHKETQEKSDQEPSQNIQEDNSDEKHAENEENVEQIETDSNVSEEANDENKDNMQTTTDEGTEELQQNDEDAESLTKENSKSEEQENEDSTDAEAIDKEEVETEEKGKDEQKKDEQKEQDEEEDGEKENKHKSSETTNETVTDIEENKNEVKGEEHLQGSEQSIEASESSQKDETKETEDKEEYVNANDDESSEEDTTPNETNKTDNGS | ||||||
Compositional bias | 725-771 | Basic and acidic residues | ||||
Sequence: ESNNENKEKTSDDATHKETQEKSDQEPSQNIQEDNSDEKHAENEENV | ||||||
Compositional bias | 782-796 | Basic and acidic residues | ||||
Sequence: EEANDENKDNMQTTT | ||||||
Compositional bias | 808-824 | Basic and acidic residues | ||||
Sequence: EDAESLTKENSKSEEQE | ||||||
Compositional bias | 838-853 | Basic and acidic residues | ||||
Sequence: EVETEEKGKDEQKKDE | ||||||
Compositional bias | 861-921 | Basic and acidic residues | ||||
Sequence: EDGEKENKHKSSETTNETVTDIEENKNEVKGEEHLQGSEQSIEASESSQKDETKETEDKEE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length969
- Mass (Da)112,574
- Last updated2003-03-01 v1
- Checksum323C98B89520153C
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 229-261 | Polar residues | ||||
Sequence: DSSSMEIQDSTSNEQDENVKGMSSSQEMNSNND | ||||||
Compositional bias | 272-297 | Polar residues | ||||
Sequence: DDVNNNNNNNNDDQDEQGNDGDVTSS | ||||||
Compositional bias | 311-326 | Polar residues | ||||
Sequence: SSNDVNNNTDTLVNNK | ||||||
Compositional bias | 688-724 | Polar residues | ||||
Sequence: SSNFNIFDSNNTDQNNEQEQPKQDDQLLNNNNDDVLS | ||||||
Compositional bias | 725-771 | Basic and acidic residues | ||||
Sequence: ESNNENKEKTSDDATHKETQEKSDQEPSQNIQEDNSDEKHAENEENV | ||||||
Compositional bias | 782-796 | Basic and acidic residues | ||||
Sequence: EEANDENKDNMQTTT | ||||||
Compositional bias | 808-824 | Basic and acidic residues | ||||
Sequence: EDAESLTKENSKSEEQE | ||||||
Compositional bias | 838-853 | Basic and acidic residues | ||||
Sequence: EVETEEKGKDEQKKDE | ||||||
Compositional bias | 861-921 | Basic and acidic residues | ||||
Sequence: EDGEKENKHKSSETTNETVTDIEENKNEVKGEEHLQGSEQSIEASESSQKDETKETEDKEE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LN999946 EMBL· GenBank· DDBJ | CZT99914.1 EMBL· GenBank· DDBJ | Genomic DNA |