Q8ILP3 · P113_PLAF7

Function

function

Membrane receptor which tethers secreted RH5 to the merozoite membrane during merozoite invasion of host erythocytes.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Cellular Componentside of membrane
Cellular Componentsymbiont-containing vacuole membrane

Names & Taxonomy

Protein names

  • Recommended name
    Surface protein P113

Gene names

    • Name
      P113
    • ORF names
      PF3D7_1420700

Organism names

  • Taxonomic identifier
  • Strain
    • 3D7
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    Q8ILP3

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue (large scale data), lipidation, propeptide.

TypeIDPosition(s)SourceDescription
Signal1-22UniProt
ChainPRO_501910773423-945UniProtSurface protein P113
Glycosylation207UniProtN-linked (GlcNAc...) asparagine
Glycosylation268UniProtN-linked (GlcNAc...) asparagine
Glycosylation317UniProtN-linked (GlcNAc...) asparagine
Glycosylation360UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)504PTMeXchangePhosphoserine
Glycosylation661UniProtN-linked (GlcNAc...) asparagine
Glycosylation697UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)776PTMeXchangePhosphothreonine
Modified residue (large scale data)778PTMeXchangePhosphoserine
Glycosylation779UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)781PTMeXchangePhosphoserine
Modified residue (large scale data)812PTMeXchangePhosphoserine
Modified residue (large scale data)818PTMeXchangePhosphoserine
Modified residue (large scale data)820PTMeXchangePhosphoserine
Modified residue (large scale data)828PTMeXchangePhosphoserine
Modified residue (large scale data)829PTMeXchangePhosphothreonine
Glycosylation876UniProtN-linked (GlcNAc...) asparagine
Modified residue (large scale data)880PTMeXchangePhosphothreonine
Modified residue (large scale data)901PTMeXchangePhosphoserine
Modified residue (large scale data)930PTMeXchangePhosphoserine
Glycosylation938UniProtN-linked (GlcNAc...) asparagine
Glycosylation941UniProtN-linked (GlcNAc...) asparagine
Lipidation945UniProtGPI-anchor amidated asparagine
Glycosylation945UniProtN-linked (GlcNAc...) asparagine
PropeptidePRO_0000448667946-969UniProtRemoved in mature form

Keywords

Proteomic databases

PTM databases

Expression

Developmental stage

Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).

Interaction

Subunit

Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186).
Within the complex, interacts with RH5 (via N-terminus); the interaction tethers RH5 to the merozoite membrane (PubMed:28186186).

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region223-328Disordered
Compositional bias229-261Polar residues
Compositional bias272-297Polar residues
Compositional bias311-326Polar residues
Compositional bias688-724Polar residues
Region688-947Disordered
Compositional bias725-771Basic and acidic residues
Compositional bias782-796Basic and acidic residues
Compositional bias808-824Basic and acidic residues
Compositional bias838-853Basic and acidic residues
Compositional bias861-921Basic and acidic residues

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    969
  • Mass (Da)
    112,574
  • Last updated
    2003-03-01 v1
  • Checksum
    323C98B89520153C
MKIPFFILHILLLQFLLCLIRCYVHNDVIKFGEENSLKCSQGNLYVLHCEVQCLNGNNEIIHKRCNDDIEKKCNGNNKCIYFFEYELRKKTQSFRNKNSIEISECVESEQNEVKTSTTCLLSNSFILDEAFIQYFFFIKNKNEEPVICKDGNINIKSALLHSPFCEIKLKDISEYIRKKCDNNKECLIDPLDVQKNLLNEEDPCYINNSYVSVNVVCNKEEEIGDESTDSSSMEIQDSTSNEQDENVKGMSSSQEMNSNNDENKNQDNESDDDVNNNNNNNNDDQDEQGNDGDVTSSMNKNEDNKDLEHGSSNDVNNNTDTLVNNKENKEFVLKEKSSLTSKINKELAHRTALFNKLADNISLLLNKKYDSFEIKDVLEDRYNEMKRDANPDVYYIYLMDTLDIEKIEDINLEEVKMSLLASLKETMNKIDTIEKKIEEFKNKYISLYNKVKTTMPELFDLNEDLVLLYNDFPFDNGMISSDIFFKYNPSENIMDHQEMVKKGSITEDELRIVNDLEPLDNYRRRKRITELRKILVEKLRILYLEKNNLFNTQASCIKSYCYKNPLNLKTLEVLLKKNYYRLKENKDYDVVSSIIQHLDNVDANKKKKWLTHERILKKLQVLIAEGYKRINEKEKDIDRRMAVYNALYEKAQSYNLQKLFNDSNDFLKKYAIMGNSFDDGDEVFGSQSSNFNIFDSNNTDQNNEQEQPKQDDQLLNNNNDDVLSESNNENKEKTSDDATHKETQEKSDQEPSQNIQEDNSDEKHAENEENVEQIETDSNVSEEANDENKDNMQTTTDEGTEELQQNDEDAESLTKENSKSEEQENEDSTDAEAIDKEEVETEEKGKDEQKKDEQKEQDEEEDGEKENKHKSSETTNETVTDIEENKNEVKGEEHLQGSEQSIEASESSQKDETKETEDKEEYVNANDDESSEEDTTPNETNKTDNGSSFFFAMSNALLVILLLLFIEFL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias229-261Polar residues
Compositional bias272-297Polar residues
Compositional bias311-326Polar residues
Compositional bias688-724Polar residues
Compositional bias725-771Basic and acidic residues
Compositional bias782-796Basic and acidic residues
Compositional bias808-824Basic and acidic residues
Compositional bias838-853Basic and acidic residues
Compositional bias861-921Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN999946
EMBL· GenBank· DDBJ
CZT99914.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp