Q8IIW9 · SUFD_PLAF7

Function

function

Participates in the sulfur mobilization (SUF) pathway for iron-sulfur (Fe-S) cluster biogenesis (PubMed:28695709).
As part of a complex consisting of SufB-SufC2-SufD, involved in assembly of [4Fe-4S] clusters (PubMed:28695709).
Enhances the ATPase activity of SufC (PubMed:28695709).

Pathway

Cofactor biosynthesis; iron-sulfur cluster biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapicoplast
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionmetal ion binding
Biological Processiron-sulfur cluster assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Iron-sulfur cluster assembly protein SufD
  • Short names
    PfSufD

Gene names

    • Name
      SufD
    • ORF names
      PF3D7_1103400

Organism names

  • Taxonomic identifier
  • Strain
    • 3D7
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    Q8IIW9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Disruption phenotype

Parasites require exogenously provided mevalonate for survival (PubMed:37166116).
No significant effects on apicoplast morphology (PubMed:37166116).

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00004595901-1462UniProtIron-sulfur cluster assembly protein SufD
Modified residue (large scale data)716PTMeXchangePhosphoserine

Post-translational modification

Proteolytically cleaved.

Proteomic databases

Interaction

Subunit

Component of a complex composed of SufB, SufC and SufD in a stoichiometric ratio of 1:2:1 (PubMed:28695709).
Interacts with SufB (PubMed:28695709).
Interacts with SufC; the interaction enhances the ATPase activity of SufC (PubMed:28695709).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region500-525Disordered
Region938-970Disordered
Compositional bias944-963Polar residues
Compositional bias1111-1142Polar residues
Region1111-1153Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,462
  • Mass (Da)
    172,391
  • Last updated
    2003-03-01 v1
  • Checksum
    0612BA55689D6A14
MPNIFLSNYIFIFILLTNKFLKTFDYVESKHWNNICLKDLYDKNDIKLNKTNKLKLKYKNFMFSDLKKQKKRKETETATGTITQKQKHTKKKKLHGQTNGYFIKRNKIQHIFANIPYNNNFKKINQDIYTFKNVNYHPKNANKKVYLKINNATHLETIKTYITKCIKNYRHQNEEKTQKKIRNYNNIIQYYVSRKNNNNNNNNRFIHTYNMLFINIFYNIISKNRNEKKKKNRKTDFQKYLRKYEELYQKFTPENDAENNDINNDKNNSDLISQINKKNISNIIINEWCLRNNNEKYNSTLMYDYISNMHNTEYQDITCVNNFIKNNEMIEKETWEHKQKPYLTYKYEFKYRDPINRKNKLYQYEYYIPKLITYEEDISTEPKFVPSNFKSPKCYNNSPVNALTTSGFSSRNIDTFGKERNKIYSFNTPTDVKRNIFFDDLILISSSYNQHFFPNLNFLLNLHTLQILIRDKTAIETDYMIDKFDQLKEKLIQINSPHVIDNNQNDDIDNNNNNNNNNNNCDNPYNKRIIPINNKSTNNDACTIDNISNIQHRKNQTNDQNNKSKDDEINEEISSNLTYKKTLFDDKIQLFKNKYDKNILDDKDFVQLWKYNEKGEIVETINKIPIPKIYLNIDDPKYLSWKILQNSGKTAFKEIPTPNRKLEAWRQQVNLKTFYKQNFDSSISLRNISKEELVDYKMKIVDNTFEKNEKVQNDISDHFDNIKMDNQQNEEKVELNENINYYNSDNINGDNINGDNINGDNINGDNINGDNINGDNINGDNINGDNINGDNINGDNINGDNINDDNINDDNINDVNNNHNNNHNSDNHYYYGDTHKINNQNKKNVNETINISENTNMDDNNNNEIYSQNYKEQRIKNQDISNNAYNFNKEHIDKCKRKYKKAFYTLVVRDGIVDEYLSDDINILKNLDNKLKKKSEINQNKENENENENNSQSDNNTTKQHIQDEQGTEQKKSKIFVGSFFNVKDVEIEYLINKELYFIPEHSNWYKTNTQPFIRGQIGKQSRKFDNDYPIYDYRKSDFGMAKFSSLNLASIKDCAVVYLDENIDLSDKFIHVIFIATSKNEDIDNNNNNNDNNNDNDIYEKQSKYNVYENIPSNNKQTNSNNNSEYNNEQNNCSNKQITNDEQNDNEYEKEESIQKCHMEKVISSHDDTIQNCDIEKNECKENKKSKYTQIKLTEYHTHNPITNPRLVVYVKGNSKINIYESHISLNKSNSGLVNGFSRICLEEKSNVKHTLSQELGNNVWHFHNVSVKNGLNANYKFVDVLLGSLSSRINLQIEGEKGCKQESYGLSLLEDKQNISQYEMFHHEHPSMETNQLFKCLVSDKAHAVWRSRGRIERNAIKAKLNTLCKSILLNFGASAVCIPTLEIIPSDIECANHGATISDLEKEPIFSLMTRGISERNAREIMMNSFVKEILDHISDENLKNRVYQKVLKFSQKYKSSTY

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias944-963Polar residues
Compositional bias1111-1142Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN999945
EMBL· GenBank· DDBJ
CZT98699.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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