Q8IID4 · DYHC2_PLAF7
- ProteinDynein heavy chain-like protein 2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids5251 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
Biotechnology
Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 1895-1902 | ATP (UniProtKB | ChEBI) | |||
Binding site | 2224-2231 | ATP (UniProtKB | ChEBI) | |||
Binding site | 2546-2553 | ATP (UniProtKB | ChEBI) | |||
Binding site | 2890-2897 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | dynein complex | |
Cellular Component | microtubule | |
Cellular Component | microtubule associated complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | cytoskeletal motor activity | |
Molecular Function | dynein intermediate chain binding | |
Molecular Function | dynein light intermediate chain binding | |
Molecular Function | microtubule motor activity | |
Molecular Function | minus-end-directed microtubule motor activity | |
Biological Process | microtubule-based movement |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDynein heavy chain-like protein 2
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionQ8IID4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | ||
---|---|---|---|---|---|---|
Chain | PRO_0000370750 | 1-5251 | UniProt | Dynein heavy chain-like protein 2 | ||
Modified residue (large scale data) | 154 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 1043 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 4029 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 4105 | PTMeXchange | Phosphothreonine | |||
Modified residue (large scale data) | 4115 | PTMeXchange | Phosphothreonine | |||
Modified residue (large scale data) | 4195 | PTMeXchange | Phosphothreonine | |||
Modified residue (large scale data) | 4205 | PTMeXchange | Phosphothreonine | |||
Modified residue (large scale data) | 4812 | PTMeXchange | Phosphoserine | |||
Modified residue (large scale data) | 4815 | PTMeXchange | Phosphoserine | |||
Proteomic databases
Expression
Keywords
- Developmental stage
Interaction
Subunit
Consists of at least two heavy chains and a number of intermediate and light chains.
Protein-protein interaction databases
Family & Domains
Features
Showing features for repeat, compositional bias, region, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Repeat | 37-87 | Kelch 1 | |||
Repeat | 95-143 | Kelch 2 | |||
Compositional bias | 140-173 | Polar residues | |||
Region | 140-188 | Disordered | |||
Compositional bias | 174-188 | Basic and acidic residues | |||
Repeat | 266-317 | Kelch 3 | |||
Repeat | 318-367 | Kelch 4 | |||
Repeat | 372-421 | Kelch 5 | |||
Region | 686-732 | Disordered | |||
Coiled coil | 1155-1225 | ||||
Coiled coil | 1544-1610 | ||||
Region | 1554-1598 | Disordered | |||
Repeat | 1639-1685 | Kelch 6 | |||
Region | 1802-1825 | Disordered | |||
Coiled coil | 2136-2188 | ||||
Region | 2152-2171 | Disordered | |||
Repeat | 2447-2494 | Kelch 7 | |||
Compositional bias | 3138-3152 | Polar residues | |||
Region | 3138-3163 | Disordered | |||
Compositional bias | 3652-3676 | Polar residues | |||
Region | 3652-3686 | Disordered | |||
Compositional bias | 4042-4060 | Basic and acidic residues | |||
Region | 4042-4250 | Disordered | |||
Compositional bias | 4061-4091 | Acidic residues | |||
Compositional bias | 4092-4250 | Basic and acidic residues | |||
Region | 4280-4299 | Disordered | |||
Compositional bias | 4773-4800 | Polar residues | |||
Region | 4773-4824 | Disordered | |||
Region | 4910-4948 | Disordered | |||
Domain
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
Sequence similarities
Belongs to the dynein heavy chain family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length5,251
- Mass (Da)617,381
- Last updated2003-03-01 v1
- MD5 ChecksumCB3AFFDF5C6B8F5EEE634761A3721529
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 140-173 | Polar residues | |||
Compositional bias | 174-188 | Basic and acidic residues | |||
Compositional bias | 3138-3152 | Polar residues | |||
Compositional bias | 3652-3676 | Polar residues | |||
Compositional bias | 4042-4060 | Basic and acidic residues | |||
Compositional bias | 4061-4091 | Acidic residues | |||
Compositional bias | 4092-4250 | Basic and acidic residues | |||
Compositional bias | 4773-4800 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
LN999945 EMBL· GenBank· DDBJ | CZT98891.1 EMBL· GenBank· DDBJ | Genomic DNA |