Q8IH79 · Q8IH79_DROME
- ProteinGH01059p
- Geneemb
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids697 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score1/5
Publications for Q8IH79
A novel period mutation implicating nuclear export in temperature compensation of the Drosophila circadian clock.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0020497
beta-importin Tnpo-SR promotes germline stem cell maintenance and oocyte differentiation in female Drosophila.
- CategoryFunction
- SourceFlyBase: FBgn0020497
CK2 Inhibits TIMELESS Nuclear Export and Modulates CLOCK Transcriptional Activity to Regulate Circadian Rhythms.
- CategoryPTM / Processing
- SourceFlyBase: FBgn0020497
Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in <i>Drosophila</i> Males.
- CategoriesFunction, Subcellular Location
- SourceFlyBase: FBgn0020497
Specialization of the <i>Drosophila</i> nuclear export family protein Nxf3 for piRNA precursor export.
- CategoryFunction
- SourceFlyBase: FBgn0020497
FUS-induced neurotoxicity in Drosophila is prevented by downregulating nucleocytoplasmic transport proteins.
- AnnotationNucleoporin 154 and Exportin1 (XPO1) prevented FUS-induced neurotoxicity. Moreover we show that XPO1 interacted with FUS. Silencing XPO1 significantly reduced the propensity of FUS to form inclusions upon stress.
- CategoriesFunction, Expression
- SourceFlyBase: FBgn0020497, GeneRif: 34167
Karyopherin alpha-3 is a key protein in the pathogenesis of spinocerebellar ataxia type 3 controlling the nuclear localization of ataxin-3.
- CategoriesFunction, Interaction, Subcellular Location
- SourceFlyBase: FBgn0020497
Drosophila O-GlcNAcase Deletion Globally Perturbs Chromatin O- GlcNAcylation.
- CategoriesFunction, Phenotypes & Variants
- SourceFlyBase: FBgn0020497
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.
- CategoryFunction
- SourceFlyBase: FBgn0020497
The C9orf72 repeat expansion disrupts nucleocytoplasmic transport.
- CategoryFunction
- SourceFlyBase: FBgn0020497
A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin.
- AnnotationNuclear export of TIS11 proteins is mediated by CRM1 through diverging nuclear export signals while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 folding.
- CategorySubcellular Location
- SourceGeneRif: 34167
The Hippo kinase promotes Scalloped cytoplasmic localization independently of Warts in a CRM1/Exportin1-dependent manner in Drosophila.
- AnnotationHPO promotes the translocation of SD to the cytoplasm in a CRM1-dependent manner
- CategoriesFunction, Interaction
- SourceGeneRif: 34167
Dimerization and cytoplasmic localization regulate Hippo kinase signaling activity in organ size control.
- CategoryInteraction
- SourceFlyBase: FBgn0020497
The importance of exportin and Ran for nucleocytoplasmic shuttling of the ecdysteroid receptor.
- AnnotationNuclear localization of the ecdysteroid receptor (EcR) is increased in HeLa cells if exportin-1 (CRM1) is knocked down by siRNA against exportin.
- CategoryFunction
- SourceGeneRif: 34167
The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila.
- CategoryFunction
- SourceFlyBase: FBgn0020497
Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export.
- CategorySubcellular Location
- SourceFlyBase: FBgn0020497
The nuclear transport machinery as a regulator of Drosophila development.
- CategoryFunction
- SourceFlyBase: FBgn0020497