Q8IBG1 · DYHC1_PLAF7

Function

function

Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).

Biotechnology

Possible candidate for an effective malaria vaccine as determined by epitope response in sera.

Features

Showing features for binding site.

150655001,0001,5002,0002,5003,0003,5004,0004,5005,000
TypeIDPosition(s)Description
Binding site1996-2003ATP (UniProtKB | ChEBI)
Binding site2319-2326ATP (UniProtKB | ChEBI)
Binding site2790-2797ATP (UniProtKB | ChEBI)
Binding site3135-3142ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell cortex
Cellular Componentcytoplasmic dynein complex
Cellular Componentcytoplasmic microtubule
Cellular Componentmicrotubule associated complex
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functiondynein intermediate chain binding
Molecular Functiondynein light intermediate chain binding
Molecular Functionmicrotubule motor activity
Molecular Functionminus-end-directed microtubule motor activity
Biological Processcytoplasmic microtubule organization
Biological Processmicrotubule-based movement
Biological Processmitotic spindle organization
Biological Processnuclear migration

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dynein heavy chain-like protein 1

Gene names

    • ORF names
      MAL7P1.162, PF3D7_0729900

Organism names

Accessions

  • Primary accession
    Q8IBG1
  • Secondary accessions
    • A0A143ZY83
    • C0H4Q3

Proteomes

Organism-specific databases

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003568281-5065UniProtDynein heavy chain-like protein 1
Modified residue (large scale data)1268PTMeXchangePhosphoserine
Modified residue (large scale data)4669PTMeXchangePhosphoserine

Proteomic databases

Expression

Developmental stage

Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.

Keywords

Interaction

Subunit

Consists of at least two heavy chains and a number of intermediate and light chains.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, coiled coil, compositional bias.

TypeIDPosition(s)Description
Region1-1957Stem
Coiled coil1677-1705
Region1958-2179AAA 1
Region2203-2223Disordered
Region2281-2632AAA 2
Region2507-2529Disordered
Region2751-3004AAA 3
Region3097-3367AAA 4
Region3386-3701Stalk
Coiled coil3388-3466
Region3754-3983AAA 5
Coiled coil3970-3997
Region4289-4507AAA 6
Compositional bias4686-4708Basic and acidic residues
Region4686-4727Disordered
Compositional bias4709-4727Polar residues

Domain

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

Sequence similarities

Belongs to the dynein heavy chain family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    5,065
  • Mass (Da)
    591,698
  • Last updated
    2021-09-29 v3
  • Checksum
    0C548A290C5207F9

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias4686-4708Basic and acidic residues
Compositional bias4709-4727Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL844506
EMBL· GenBank· DDBJ
CZT62681.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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