Q8IBG1 · DYHC1_PLAF7
- ProteinDynein heavy chain-like protein 1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids5065 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).
Biotechnology
Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell cortex | |
Cellular Component | cytoplasmic dynein complex | |
Cellular Component | cytoplasmic microtubule | |
Cellular Component | microtubule associated complex | |
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | dynein intermediate chain binding | |
Molecular Function | dynein light intermediate chain binding | |
Molecular Function | microtubule motor activity | |
Molecular Function | minus-end-directed microtubule motor activity | |
Biological Process | cytoplasmic microtubule organization | |
Biological Process | microtubule-based movement | |
Biological Process | mitotic spindle organization | |
Biological Process | nuclear migration |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDynein heavy chain-like protein 1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionQ8IBG1
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000356828 | 1-5065 | UniProt | Dynein heavy chain-like protein 1 | |||
Sequence: MELEKTHLINYFLEICPTVLDCSRKELQSVLIKKEEEKIRKFLLDKNINLIVIGKEGNDNVEREMDDKENDNVDINMNEEYNSMRTSNLDNKYNNFLFVELMINYKCVTKSISIAFMKRNKENFLSLNDKIDNRNKINLSNELLMFVCGQNDCNTPLDLVYLYLSQGFNNIFDAASGYGQNISGPDSSHFNYGTKKDVENMFSINNKYIGYEGENKVSNILMNNVSKKLNELLISMKNAQIDLNIPIINLHVDKRIKKLLEENPNVDDMKPDKLKQLCESQEFINQLQKDVTKWIEDIQKLTRLNGEFKSGGSALSEINFWIGYENALYQLESQLKNPEVILTLHILKNAKRYFATMSFDSDIQLKQSKEYVLNVNILMKDFPIEDLLGATSIQQIIQAVRNIFNHLKKLKNTTKYPLSRSYNFVESLSRDLNNTMKKVLCTQSLMNMDYEEFDVLISGCVEIFRLWNEEMRIFKDMVRELIKKRSFNERAPAKMVFEHIHLQERLDEIKKFRKQHEKFKSVISTVFGSNNKSLGINLYKDINTAYNIFLSLDPLDLSKNGEDNWEKAKLSYESKVNRVESQITFKLRDQLGGSKTSAEMFHAFSKFNPLFFRPKIRGAIQEYQNTLIQIVVDDLRKLQMIYINGYLKSDSQKVSTIRDIPLVAGSIIWAKQIERKLEDSLKRIENVLGRGWEQHSEGKILRQNIDNFKNLLSQNKTFEKWLKNIKSADKFDMYDNIINIKKLGGNNYEILANYDFQFFNIFKEVRYLQSINLRVPYSIKVKADETKLIYPYALTLQKTFRTYMKICISMDNQAKDVPFNQTIKKLVAAIHNTVQNKIKEGIYLHWDSDIIETYVRKLSETINTFEFMVDEAMNKNKIVLDSLEKMKTCEVCFDCNELKSLIEIIQKKADELYLEHYRNVHIWIEELNIHINKILTERLEEIIKTWTCEFVNWPNNGKRFICKENIHEFKIKNQKFYLHPSIDSMRQIWFSKLSDAINIICGITRIKNIYQKKEKTNEKIQIKSKGKNTNNEKDDDYIYYTNDSNNKNNIYKNKCDDNNNNIVINDVILDNTYKYIIYFIDKKIYDNAIKSINDMVDKAQKYESIWLQYKTLWQIEIGDIISSFGEDIETWKIFMNEIKQTENTFDTLDTEKYFGPIVIDYRILQSKVSSKFEIWQKEIVSEFSKKLGEKTLYLKEEIEKALYDLNTQSELKNETEITAMHILSMTPKDIVGIMNTYDMDILSKTCNSIYNFIEKINEINKKEELEWSKKCDLLKQSEVLLEKQRYTFPTNWLYIDNIIGKLETVKQICKYQIKLIKDYLPYIQSMVLDFDRKVQNNIKELFEEWNKNKPSHGNANSTKALQIITTFEERIDIINEQYEISEKIRKLLELENSESEIGFHVSPNILKEEINCVKGIWDELKIIYSNICDMKKMLWSNVDPKDVKHRLNNLLESIKKIPAKYRQYEIFDNVQNEIQQYLKTYSLLLDLKSESLKERHWKLILQKLNIKIYYNKLTLGNLWSLHLCIHENVLSEILNQAQGEMALEQFLRGLKDTWNEYELELVQYQNKCKLIKGWNDIFSTIDDHLNAIQSMKISSYIKIFEEETFTWDDKLNRLRNLLDVWMNVQRKWVYLEGVLKGSSDIKSLLPQEYNRFKIIDSDFINIMKKTSDKPKLLELFQMEGFQKQLDRLSDSLSKIQKALGEYLEKQRNKFPRFYFVGDEDLLEMIGNSKDAKIIQRNVNKMFAGINSFILKENTNDIILGMSSREGEEVLFLEALNISSFNTLKEWLIVLEKSMKSSLEFYLDEAAKEILEMDMIECTKIENNKILLWSEKYPNQIILLCLQILWTTNIENELINFSKNPPDESNTLFHKSEKICLNLLEFLAVNVVKQKDHRTRQKFVQMITELVHQRDVIRILIDKNVNNVNSFIWLQYMRYYWDSKKKENKINLIIKMADATFEYGYEYLGMCEKLVQTELTDACFLTLTQALKMKLGGNPFGPAGTGKTESVKALGAQLGRYVLVFNCDESFDFTAMGRIFVGLCQVGAWGCFDEFNRLEERILSAVSEQILTIQTSLVQRKNEIEILNKKIGLNKNVGIFVTMNPGYAGRSNLPDNLKQLFRSFAMIEPNKQLIVEVTLFSQGFISAEHLSSKIVSLFDLCSEQLSKQPHYDFGLRSLKSVLNSAGNLKRLTLLKDESKYVQNNQIGFNETLDNNNNNDNNNERKTTTNTNESNIISMEQTLLLKSVCDTVYPKLVSSDIILIQSLLKGVFPNVNVGDLEEKGLINEIHRLCKLRHFTPEEKWITKICQIYQIMKLQHGVMLVGDVGTGKSSAWKILLDSLEALDNIKGVSYVIDAKSLDKEEIYGKLDNINLEWTDGVFTGILRKIIYNSSTQSGNTNKRHWIVFDGDVDPEWAENLNSVLDDNKLLTLPNGERLPIPESVRILFEVDTLKHATLATVSRCGMIWFSRDILSPIILFKHKLNMLKYGDNDYPRKMDKFKLLLINNNERITEKNQNGNENGNENEKKNINIINNNNSNNSNNIYSMNHMNNYNVNANEHNLQQFDNIDSENIMDNIRMNSRIFFEENEQETSSSYIIRTIPYRAVNIISDYFEENEFVHQCLVEAENYEHVMDYEYIRVIESTCLLLQKGFDNLVKKNEKINNTLSDDDIEKYISKWLVVSILWGIGGSLNLETREKFSMFVQSICSIPLPNDLLSKGKMPNMDNTNKISNTLLDYQPNIEDGEWINWKELVQIIDVDRTEISDATLVIETMDTIRHETILEGWLHLKKPFILCGPPGSGKTMTLTSVLKKSSEFDIASLNFSSGSLPNLLLQTFDHYCEYVKTTSELVLRPLQPGKWLIIFADEINLPTPDKYDTQRIIMFMRQIYESQGFWKYDVNNNSWNWVKIERITFAGACNPPTDAGRNPLSNRFLRHTSVLYVDFPGYESLKQIYGTFNRAILRKFPQSSHMADNLTQAMVDFYTKFSETFTIDMQPHYIYSPRELTRWKLALYETLESCDELKTKDLVRLCICEGLRIFQDRLIYKKEKKETDKIIDDIFKYSFPDITKEDLLRPILFNSYMKNYYTEIDKKDLKVLILSKLKIFNEEEINVQLVLFDDVLDHITRIDRVLRLPLGHLLLVGASGAGKTILSRFVSWINGLSVFQIRAGRNYTTESFEADLRHIMKRAGIKEEKITFIFDESNVLGPAFLERMNALLASGEVPGLFEGDNYITLINECKSAYRSNIGLDESDIFKKFTKQVQQNLHIVFTMNPANPDFANRQATSPALFNRCVIDWFGDWPYSALLQVASEFIFNLILPDNNFYMDYVGNEDGPIKGKIQYKNNKAYFLSRAIVEIHNSVVHINNVLMKKGNRYNYMTPRDFLDFIKHFLKIIDEKKEEVSSQKNHLNSGLNKLKDTEIQVAELRNSLAIKKKTLAEKDLEAEEKMKLMIEQQTETEDKKKKAEILSKKLDEQFIIIDQRKEVVRKELSEVEPKFREAEEAVKNIPKKNFDELRAMANPPILVRNAVEAVAILIMNEGDKNVTWEDARKIMKGQDFINKVLYLDKKAVKPQTSSQIKKRINNNDWDVERINKASRAAGPLAKWVESVITFLNILETVQPLEKEIEKLQEETKVAEDQYNEQRDIICELEKKLVQYKNDYAQLISQVQNIKQEMEMVENKIKRSINLIDNLKSEKERWSETFINLEEASETFVGDCLIAAAFCAYIGFFEHYERQRLKRTWGEIIKMHYIKYRNDLSFIEFLSRPSERLQWIGNELPSDDLSIENAIIINNYIRYPMIIDPSDQATTFLLNQYSDKKILKTSFSDKNFIKNLESALRFGSTLLVYDVEKIDAILNSVLNQETHKQGGRLLITIGDSEVDFSPSFNLFLTSRDAHFQFTPDLCSRVTFVNFTLTPSSLQNQCLNMILKNERPDIDKKRCDLLKLQGEYKVKIRELEESLLLELSNVKGNILDDDNVISTMEKLKVQGAEASKEVNIAEEVMVEVENVSNQYLFLAQGSARIYFILQHLCNINFLYQYDLNFFFNIMKDMFNNDHLLSIVKKKDHYKERLKVLEDLLFSLTYNRVARGLLQEDRYVFGLQLCYVKSIINPNIDMDQSYLHYLLKDHYSNQEIDEFEHKKIEKNLLPEYNDEQINALNNLIKHKSFSNLKKCILNNKQKWIELLHSAEPEELVCSILNDMNMSEESMDKSDEMLNKNKNLNILNNVEFGKDDDIPEEKRYINNDNTNMDTTTKNNNNMNNNNNMNNNNNYMLQNKNDISSCLKESLIIKAIRPDKLENCFNKIINHILGRDFLWIPELSMNDFEKYVKENANGNIPIVLISSPGFDPSNKVQQLSEKCKIPLFSIAMGSEEGYISAERVIFTAQSNGGWVLLKNIHISTKWLHELEKNIHKATTNKNFRLFLTMEFNPRIPQSLMRISLTFMFEPPVGIKFSILRSFSLFLENRELCEPKIARLRLYFIVSYLHAIILERRRYTPIGWTKKYEFSDSDLMCALSVVDSWLDKASTKIGKNVSEHIDPCNIPWEAIKKILNEAIYGGRLDNMVDQKILDTFIDHLMNSNSFETDFKLNICNSTSLNKDFLVSPDLFRNINDYINWTNNMSNTDLPAWLGFGQQAEGLLTTRTNFSIISKWNILYSKSRSDVYEPLPHSPLTKSLNEEKYISFEQYKIKNIKEKTIKDKDKNKDEDKNKNKENDDNNKKHIGNNKLVISSSERTESETSESSCTVSRSIHVYSNNENILFINKILENLPQNIPCLEKNEEKLRNAVFRCFERENNLFSDLLKLIKTNLNQLKNVLEEKVKYTNKIRALAKDLNSFNVPSNWLLDGNTTNLNLTNWLKELINRLYQIIVITLEFNEKSCIDINEKKKQKNINIENNEDHNLNDFYKRNNDNILSHFKLNNKEKKLSINFIWLGGLFYPRAFITATRQLSAFKFKNSLDDLELSVLIGNNNNMKYDDMIHFTITCLSIEGAEWSNKDNCLILSDELTIDLPPVTLTWEKKEILKQKQKESSSSLHFMNLPIYLDKSRNSFIGFWNFPVSKGISEQIWYQRGVAIFLSKTY | |||||||
Modified residue (large scale data) | 1268 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 4669 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Developmental stage
Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.
Keywords
- Developmental stage
Interaction
Subunit
Consists of at least two heavy chains and a number of intermediate and light chains.
Protein-protein interaction databases
Family & Domains
Features
Showing features for region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-1957 | Stem | ||||
Sequence: MELEKTHLINYFLEICPTVLDCSRKELQSVLIKKEEEKIRKFLLDKNINLIVIGKEGNDNVEREMDDKENDNVDINMNEEYNSMRTSNLDNKYNNFLFVELMINYKCVTKSISIAFMKRNKENFLSLNDKIDNRNKINLSNELLMFVCGQNDCNTPLDLVYLYLSQGFNNIFDAASGYGQNISGPDSSHFNYGTKKDVENMFSINNKYIGYEGENKVSNILMNNVSKKLNELLISMKNAQIDLNIPIINLHVDKRIKKLLEENPNVDDMKPDKLKQLCESQEFINQLQKDVTKWIEDIQKLTRLNGEFKSGGSALSEINFWIGYENALYQLESQLKNPEVILTLHILKNAKRYFATMSFDSDIQLKQSKEYVLNVNILMKDFPIEDLLGATSIQQIIQAVRNIFNHLKKLKNTTKYPLSRSYNFVESLSRDLNNTMKKVLCTQSLMNMDYEEFDVLISGCVEIFRLWNEEMRIFKDMVRELIKKRSFNERAPAKMVFEHIHLQERLDEIKKFRKQHEKFKSVISTVFGSNNKSLGINLYKDINTAYNIFLSLDPLDLSKNGEDNWEKAKLSYESKVNRVESQITFKLRDQLGGSKTSAEMFHAFSKFNPLFFRPKIRGAIQEYQNTLIQIVVDDLRKLQMIYINGYLKSDSQKVSTIRDIPLVAGSIIWAKQIERKLEDSLKRIENVLGRGWEQHSEGKILRQNIDNFKNLLSQNKTFEKWLKNIKSADKFDMYDNIINIKKLGGNNYEILANYDFQFFNIFKEVRYLQSINLRVPYSIKVKADETKLIYPYALTLQKTFRTYMKICISMDNQAKDVPFNQTIKKLVAAIHNTVQNKIKEGIYLHWDSDIIETYVRKLSETINTFEFMVDEAMNKNKIVLDSLEKMKTCEVCFDCNELKSLIEIIQKKADELYLEHYRNVHIWIEELNIHINKILTERLEEIIKTWTCEFVNWPNNGKRFICKENIHEFKIKNQKFYLHPSIDSMRQIWFSKLSDAINIICGITRIKNIYQKKEKTNEKIQIKSKGKNTNNEKDDDYIYYTNDSNNKNNIYKNKCDDNNNNIVINDVILDNTYKYIIYFIDKKIYDNAIKSINDMVDKAQKYESIWLQYKTLWQIEIGDIISSFGEDIETWKIFMNEIKQTENTFDTLDTEKYFGPIVIDYRILQSKVSSKFEIWQKEIVSEFSKKLGEKTLYLKEEIEKALYDLNTQSELKNETEITAMHILSMTPKDIVGIMNTYDMDILSKTCNSIYNFIEKINEINKKEELEWSKKCDLLKQSEVLLEKQRYTFPTNWLYIDNIIGKLETVKQICKYQIKLIKDYLPYIQSMVLDFDRKVQNNIKELFEEWNKNKPSHGNANSTKALQIITTFEERIDIINEQYEISEKIRKLLELENSESEIGFHVSPNILKEEINCVKGIWDELKIIYSNICDMKKMLWSNVDPKDVKHRLNNLLESIKKIPAKYRQYEIFDNVQNEIQQYLKTYSLLLDLKSESLKERHWKLILQKLNIKIYYNKLTLGNLWSLHLCIHENVLSEILNQAQGEMALEQFLRGLKDTWNEYELELVQYQNKCKLIKGWNDIFSTIDDHLNAIQSMKISSYIKIFEEETFTWDDKLNRLRNLLDVWMNVQRKWVYLEGVLKGSSDIKSLLPQEYNRFKIIDSDFINIMKKTSDKPKLLELFQMEGFQKQLDRLSDSLSKIQKALGEYLEKQRNKFPRFYFVGDEDLLEMIGNSKDAKIIQRNVNKMFAGINSFILKENTNDIILGMSSREGEEVLFLEALNISSFNTLKEWLIVLEKSMKSSLEFYLDEAAKEILEMDMIECTKIENNKILLWSEKYPNQIILLCLQILWTTNIENELINFSKNPPDESNTLFHKSEKICLNLLEFLAVNVVKQKDHRTRQKFVQMITELVHQRDVIRILIDKNVNNVNSFIWLQYMRYYWDSKKKENKINLIIKMADATFE | ||||||
Coiled coil | 1677-1705 | |||||
Sequence: QMEGFQKQLDRLSDSLSKIQKALGEYLEK | ||||||
Region | 1958-2179 | AAA 1 | ||||
Sequence: YGYEYLGMCEKLVQTELTDACFLTLTQALKMKLGGNPFGPAGTGKTESVKALGAQLGRYVLVFNCDESFDFTAMGRIFVGLCQVGAWGCFDEFNRLEERILSAVSEQILTIQTSLVQRKNEIEILNKKIGLNKNVGIFVTMNPGYAGRSNLPDNLKQLFRSFAMIEPNKQLIVEVTLFSQGFISAEHLSSKIVSLFDLCSEQLSKQPHYDFGLRSLKSVLNS | ||||||
Region | 2203-2223 | Disordered | ||||
Sequence: FNETLDNNNNNDNNNERKTTT | ||||||
Region | 2281-2632 | AAA 2 | ||||
Sequence: NEIHRLCKLRHFTPEEKWITKICQIYQIMKLQHGVMLVGDVGTGKSSAWKILLDSLEALDNIKGVSYVIDAKSLDKEEIYGKLDNINLEWTDGVFTGILRKIIYNSSTQSGNTNKRHWIVFDGDVDPEWAENLNSVLDDNKLLTLPNGERLPIPESVRILFEVDTLKHATLATVSRCGMIWFSRDILSPIILFKHKLNMLKYGDNDYPRKMDKFKLLLINNNERITEKNQNGNENGNENEKKNINIINNNNSNNSNNIYSMNHMNNYNVNANEHNLQQFDNIDSENIMDNIRMNSRIFFEENEQETSSSYIIRTIPYRAVNIISDYFEENEFVHQCLVEAENYEHVMDYEYI | ||||||
Region | 2507-2529 | Disordered | ||||
Sequence: EKNQNGNENGNENEKKNINIINN | ||||||
Region | 2751-3004 | AAA 3 | ||||
Sequence: DVDRTEISDATLVIETMDTIRHETILEGWLHLKKPFILCGPPGSGKTMTLTSVLKKSSEFDIASLNFSSGSLPNLLLQTFDHYCEYVKTTSELVLRPLQPGKWLIIFADEINLPTPDKYDTQRIIMFMRQIYESQGFWKYDVNNNSWNWVKIERITFAGACNPPTDAGRNPLSNRFLRHTSVLYVDFPGYESLKQIYGTFNRAILRKFPQSSHMADNLTQAMVDFYTKFSETFTIDMQPHYIYSPRELTRWKLA | ||||||
Region | 3097-3367 | AAA 4 | ||||
Sequence: IFNEEEINVQLVLFDDVLDHITRIDRVLRLPLGHLLLVGASGAGKTILSRFVSWINGLSVFQIRAGRNYTTESFEADLRHIMKRAGIKEEKITFIFDESNVLGPAFLERMNALLASGEVPGLFEGDNYITLINECKSAYRSNIGLDESDIFKKFTKQVQQNLHIVFTMNPANPDFANRQATSPALFNRCVIDWFGDWPYSALLQVASEFIFNLILPDNNFYMDYVGNEDGPIKGKIQYKNNKAYFLSRAIVEIHNSVVHINNVLMKKGNRY | ||||||
Region | 3386-3701 | Stalk | ||||
Sequence: IDEKKEEVSSQKNHLNSGLNKLKDTEIQVAELRNSLAIKKKTLAEKDLEAEEKMKLMIEQQTETEDKKKKAEILSKKLDEQFIIIDQRKEVVRKELSEVEPKFREAEEAVKNIPKKNFDELRAMANPPILVRNAVEAVAILIMNEGDKNVTWEDARKIMKGQDFINKVLYLDKKAVKPQTSSQIKKRINNNDWDVERINKASRAAGPLAKWVESVITFLNILETVQPLEKEIEKLQEETKVAEDQYNEQRDIICELEKKLVQYKNDYAQLISQVQNIKQEMEMVENKIKRSINLIDNLKSEKERWSETFINLEEAS | ||||||
Coiled coil | 3388-3466 | |||||
Sequence: EKKEEVSSQKNHLNSGLNKLKDTEIQVAELRNSLAIKKKTLAEKDLEAEEKMKLMIEQQTETEDKKKKAEILSKKLDEQ | ||||||
Region | 3754-3983 | AAA 5 | ||||
Sequence: LSRPSERLQWIGNELPSDDLSIENAIIINNYIRYPMIIDPSDQATTFLLNQYSDKKILKTSFSDKNFIKNLESALRFGSTLLVYDVEKIDAILNSVLNQETHKQGGRLLITIGDSEVDFSPSFNLFLTSRDAHFQFTPDLCSRVTFVNFTLTPSSLQNQCLNMILKNERPDIDKKRCDLLKLQGEYKVKIRELEESLLLELSNVKGNILDDDNVISTMEKLKVQGAEASK | ||||||
Coiled coil | 3970-3997 | |||||
Sequence: TMEKLKVQGAEASKEVNIAEEVMVEVEN | ||||||
Region | 4289-4507 | AAA 6 | ||||
Sequence: FNKIINHILGRDFLWIPELSMNDFEKYVKENANGNIPIVLISSPGFDPSNKVQQLSEKCKIPLFSIAMGSEEGYISAERVIFTAQSNGGWVLLKNIHISTKWLHELEKNIHKATTNKNFRLFLTMEFNPRIPQSLMRISLTFMFEPPVGIKFSILRSFSLFLENRELCEPKIARLRLYFIVSYLHAIILERRRYTPIGWTKKYEFSDSDLMCALSVVDS | ||||||
Compositional bias | 4686-4708 | Basic and acidic residues | ||||
Sequence: KDKNKDEDKNKNKENDDNNKKHI | ||||||
Region | 4686-4727 | Disordered | ||||
Sequence: KDKNKDEDKNKNKENDDNNKKHIGNNKLVISSSERTESETSE | ||||||
Compositional bias | 4709-4727 | Polar residues | ||||
Sequence: GNNKLVISSSERTESETSE |
Domain
Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.
Sequence similarities
Belongs to the dynein heavy chain family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length5,065
- Mass (Da)591,698
- Last updated2021-09-29 v3
- Checksum0C548A290C5207F9
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 4686-4708 | Basic and acidic residues | ||||
Sequence: KDKNKDEDKNKNKENDDNNKKHI | ||||||
Compositional bias | 4709-4727 | Polar residues | ||||
Sequence: GNNKLVISSSERTESETSE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL844506 EMBL· GenBank· DDBJ | CZT62681.1 EMBL· GenBank· DDBJ | Genomic DNA |