Q8I901 · Q8I901_AEDAE
- Proteinphenylalanine 4-monooxygenase
- Gene23687449
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids447 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
Catalytic activity
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 = (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine
Cofactor
Pathway
Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 1/6.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | iron ion binding | |
Molecular Function | phenylalanine 4-monooxygenase activity | |
Biological Process | L-phenylalanine catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namephenylalanine 4-monooxygenase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Nematocera > Culicoidea > Culicidae > Culicinae > Aedini > Aedes > Stegomyia
Accessions
- Primary accessionQ8I901
Proteomes
Organism-specific databases
PTM/Processing
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 33-108 | ACT | ||||
Sequence: IIFSPQQEEAGALAKMLKIFDEHRVNLLHIESRSSTRGPGYEFMVECDSKSQNLSAAIEAVRDQSDYFNIISRDYK | ||||||
Domain | 102-447 | Biopterin-dependent aromatic amino acid hydroxylase family profile | ||||
Sequence: IISRDYKDNEATVPWFPRRIRDLDRFANQILSYGAELDSDHPGFTDEKYRARRKYFADIAFNYKHGQPLPHVDYTEEEVNTWRVVFQNLTKLYPTHACREHNHVFPLLIENCGYREDNIPQLEDVSNFLKDCTGFTLRPVAGLLSSRDFLAGLAFRVFHSTQYIRHPSKPLYTPEPDVCHELLGHAPLFADPSFAQFSQEIGLASLGAPDEYIEKLATCFWFTVEFGLCRQNGELKAYGAGLLSSFGELQYCLSDKPELREFNPPQTGEQKYPITEYQPVYFVANSFDEAVQKMVAYANTIPRPFGVRYNAYTQSVEILDSKPQISNLMRNIHGEFEILQNAFKKL |
Sequence similarities
Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length447
- Mass (Da)51,134
- Last updated2003-03-01 v1
- ChecksumF34FEAC62CDFC0C2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A6I8TQR9 | A0A6I8TQR9_AEDAE | 23687449 | 456 |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY099427 EMBL· GenBank· DDBJ | AAM28250.1 EMBL· GenBank· DDBJ | mRNA |