Q8I8V0 · TAD2B_DROME
- ProteinTranscriptional adapter 2B
- GeneAda2b
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids555 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for the function of some acidic activation domains, which activate transcription from a distant site. Binds double-stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 13 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 16 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 27 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 30 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 36 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 39 | Zn2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: C | ||||||
Binding site | 49 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 53 | Zn2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | polytene chromosome | |
Cellular Component | SAGA complex | |
Cellular Component | SAGA-type complex | |
Molecular Function | chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | transcription coactivator activity | |
Molecular Function | zinc ion binding | |
Biological Process | chromatin remodeling | |
Biological Process | regulation of DNA-templated transcription | |
Biological Process | regulation of terminal button organization | |
Biological Process | regulation of transcription by RNA polymerase II | |
Biological Process | wing disc pattern formation |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameTranscriptional adapter 2B
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ8I8V0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000283734 | 1-555 | Transcriptional adapter 2B | |||
Sequence: MTTIADLFTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTSILSVFRGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGTIGRATWTPAQSQRPRLIDHTGDDDAGPLGTNALSTLPPLEINSDEAMQLGYMPNRDSFEREYDPTAEQLISNISLSSEDTEVDVMLKLAHVDIYTRRLRERARRKRMVRDYQLVSNFFRNRNYAQQQGLTKEQREFRDRFRVYAQFYTCNEYERLLGSLEREKELRIRQSELYRYRYNGLTKIAECTHFEQHAATATHRSTGPYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALLPSKNYLDSCRGSSAATMLQTTGMVMGVTVDSGATTGVTSTATTMANLPTNSAKGSQQHLQPLQQHPQLLQSGNQHKMQNEAAGGGSDQVPSMSLKLRTQLEELKHLPQPPGSELLSHNELDLCKKHNITPTTYLSVKTVCLSGAPSLGSPMETSLRKFFIKCGWLSH |
Proteomic databases
Expression
Developmental stage
Expressed both maternally and zygotically throughout development.
Gene expression databases
Interaction
Subunit
Interacts with Gcn5 and Ada3 as part of a GCN5-containing ADA multiprotein complex (PubMed:12482983).
Associated with a SAGA-type complex that also contains Taf5, e(y)1/Taf9, Taf10, Spt3 and Taf1 (PubMed:12697829).
Associated with a SAGA-type complex that also contains Taf5, e(y)1/Taf9, Taf10, Spt3 and Taf1 (PubMed:12697829).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q8I8V0 | Gcn5 O76216 | 7 | EBI-109247, EBI-867710 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for zinc finger, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Zinc finger | 8-63 | ZZ-type | ||||
Sequence: FTKYNCTNCQDDIQGIRVHCAECENFDLCLQCFAAGAEIGAHQNNHSYQFMDTGTS | ||||||
Domain | 69-121 | SANT | ||||
Sequence: RGKGAWTAREEIRLLDAIEQYGFGNWEDISKHIETKSAEDAKEEYVNKFVNGT | ||||||
Region | 318-372 | Disordered | ||||
Sequence: THRSTGPYGHGKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAP | ||||||
Compositional bias | 328-372 | Polar residues | ||||
Sequence: GKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAP |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8I8V0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameB
- Length555
- Mass (Da)62,031
- Last updated2003-03-01 v1
- Checksum89079A24FF11F381
Q8I8V0-2
- NameA
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0B4KFU2 | A0A0B4KFU2_DROME | Ada2b | 418 |
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 328-372 | Polar residues | ||||
Sequence: GKTDHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAP | ||||||
Alternative sequence | VSP_052370 | 331-418 | in isoform A | |||
Sequence: DHTHTSNGSHRPPSSSLHSPQPNLRKVEMSSGGEASSNSIAPRNTLHIADPTCSGALLPSKNYLDSCRGSSAATMLQTTGMVMGVTVD → LHCIINAPNNERSNGSIRQCLTTGPHAYLQWKSSAAKLFLALPTTESQKGRNVKRRRGKFKFNRTKKHAPHRRPDLLRRIIAQQKLLG | ||||||
Alternative sequence | VSP_052371 | 419-555 | in isoform A | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY142213 EMBL· GenBank· DDBJ | AAN52141.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014297 EMBL· GenBank· DDBJ | AAF54199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AE014297 EMBL· GenBank· DDBJ | AAZ52519.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY058546 EMBL· GenBank· DDBJ | AAL13775.1 EMBL· GenBank· DDBJ | mRNA |