Q8I8U2 · AP1G_DICDI
- ProteinAP-1 complex subunit gamma
- Geneap1g1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids895 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Also involved in early steps of phagocytosis and macropinocytosis.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | AP-1 adaptor complex | |
Cellular Component | clathrin coat of trans-Golgi network vesicle | |
Cellular Component | cytosol | |
Molecular Function | clathrin adaptor activity | |
Molecular Function | clathrin binding | |
Biological Process | Golgi to endosome transport | |
Biological Process | Golgi to vacuole transport | |
Biological Process | intracellular protein transport |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAP-1 complex subunit gamma
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Amoebozoa > Evosea > Eumycetozoa > Dictyostelia > Dictyosteliales > Dictyosteliaceae > Dictyostelium
Accessions
- Primary accessionQ8I8U2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 871 | Decrease in the interaction with rhgA. | ||||
Sequence: R → Q | ||||||
Mutagenesis | 873 | Decrease in the interaction with rhgA. | ||||
Sequence: K → Q |
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000328679 | 1-895 | AP-1 complex subunit gamma | |||
Sequence: MSSKLRDLIKTVRSCKTAAEERSQIAKESALIRTAMKEEDLESRQRNVAKLLYIHMLGYPTQFGQMECLKLIVSPSYADKRIGYLGLMLLLDEKQEVLLLATNCIRGDIMNSNQFIVGVSLCAFGNICSTAMARDISPEIEKVISHSNPYIRKKAALCAIRVLRKVPDLTENYIPKIKALLSERNHAVILTALTLIIEICEMDSTQIIHFKKMVPQLVRILKSLTSSGYLPEHDIGGVTDPFLQVKILRLLRILGQNDPEASDAMNDILAQVSTNTDSTKNVGNAILYECVQTIMTIESENGLKVMAINILGRFLLNRDNNIRYVALNTLSRVVNTDIQAVQRHRNTIVECLKDPDVSIRCRALDLIYSLVTESNIRVLVRELLNFLLIADAQFKSELVAKLCIVTEKYAPNKRWQIDTILRVMSIAGNFIPDEVPSNLIQLISSTPELSSYAVQKLYLALKQDITQQPLTQVGLWCIGEYGDLLVADKSQLPKDEDGLSLNVSEQAVIDIIDLIFRHATTTQATRQYSLTSLAKLSSRFSQSSLQRIKTMIDNYKQNINLELQQRACEYSTLFDFDKKASILDRMPPIEKQEESPHIGNKNIPTQTPPQQHYQQQQQQPQQQSSQFGSILDGLDSPTQSSANSGNNNNNNNKQGGNAMSLLEDIFGSAPTPTSNGNMNNNNNMNNMNNNMNNNYAMGGMGMNNNNNNSMGGMMNNNNNNNNNNNNNNNNNKSQASALLDIMGDLQLTPTPQQPQSQSQQALSPTNQTSVLQPVPQPLTFLVYQKHGLNISYECSKPQPNNLSLTNINMVITNTGSSPITNFSLQAAVPKYLKIQLLAPSSTVIPPNNSGEVTQVSKVLNSQQGQKPILLRLKLDFQINGQPFSDVPDTPLPSLF |
Proteomic databases
Interaction
Subunit
Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit and beta-type subunit), a medium adaptin (mu-type subunit) and a small adaptin (sigma-type subunit) (By similarity).
Interacts with rhgA
Interacts with rhgA
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 130-166 | HEAT 1 | ||||
Sequence: TAMARDISPEIEKVISHSNPYIRKKAALCAIRVLRKV | ||||||
Repeat | 167-205 | HEAT 2 | ||||
Sequence: PDLTENYIPKIKALLSERNHAVILTALTLIIEICEMDST | ||||||
Repeat | 211-256 | HEAT 3 | ||||
Sequence: KKMVPQLVRILKSLTSSGYLPEHDIGGVTDPFLQVKILRLLRILGQ | ||||||
Repeat | 301-339 | HEAT 4 | ||||
Sequence: NGLKVMAINILGRFLLNRDNNIRYVALNTLSRVVNTDIQ | ||||||
Repeat | 341-376 | HEAT 5 | ||||
Sequence: VQRHRNTIVECLKDPDVSIRCRALDLIYSLVTESNI | ||||||
Region | 591-687 | Disordered | ||||
Sequence: KQEESPHIGNKNIPTQTPPQQHYQQQQQQPQQQSSQFGSILDGLDSPTQSSANSGNNNNNNNKQGGNAMSLLEDIFGSAPTPTSNGNMNNNNNMNNM | ||||||
Compositional bias | 598-658 | Polar residues | ||||
Sequence: IGNKNIPTQTPPQQHYQQQQQQPQQQSSQFGSILDGLDSPTQSSANSGNNNNNNNKQGGNA | ||||||
Compositional bias | 667-687 | Polar residues | ||||
Sequence: GSAPTPTSNGNMNNNNNMNNM | ||||||
Region | 706-733 | Disordered | ||||
Sequence: NNNSMGGMMNNNNNNNNNNNNNNNNNKS | ||||||
Region | 746-770 | Disordered | ||||
Sequence: QLTPTPQQPQSQSQQALSPTNQTSV | ||||||
Domain | 775-893 | GAE | ||||
Sequence: PQPLTFLVYQKHGLNISYECSKPQPNNLSLTNINMVITNTGSSPITNFSLQAAVPKYLKIQLLAPSSTVIPPNNSGEVTQVSKVLNSQQGQKPILLRLKLDFQINGQPFSDVPDTPLPS |
Sequence similarities
Belongs to the adaptor complexes large subunit family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length895
- Mass (Da)99,625
- Last updated2003-03-01 v1
- ChecksumE57EA316FEA6FD84
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 598-658 | Polar residues | ||||
Sequence: IGNKNIPTQTPPQQHYQQQQQQPQQQSSQFGSILDGLDSPTQSSANSGNNNNNNNKQGGNA | ||||||
Compositional bias | 667-687 | Polar residues | ||||
Sequence: GSAPTPTSNGNMNNNNNMNNM |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY144597 EMBL· GenBank· DDBJ | AAN41659.1 EMBL· GenBank· DDBJ | mRNA | ||
AAFI02000044 EMBL· GenBank· DDBJ | EAL66400.1 EMBL· GenBank· DDBJ | Genomic DNA |