Q8I7M8 · CDK17_CAEEL

  • Protein
    Cyclin-dependent kinase 17
  • Gene
    pct-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Serine/threonine-protein kinase, which, in association with cyy-1, regulates the trafficking of synaptic vesicles in the DA9 motor neuron and probably also in the DD motor neurons and in RIA interneurons.

Isoform c

Sufficient for synaptic vesicle trafficking in the DA9 motor neuron.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site334-342ATP (UniProtKB | ChEBI)
Binding site357ATP (UniProtKB | ChEBI)
Active site449Proton acceptor
Binding site454Mg2+ (UniProtKB | ChEBI)
Binding site467Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentaxon
Cellular Componentaxon cytoplasm
Cellular Componentcyclin-dependent protein kinase holoenzyme complex
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functioncyclin-dependent protein serine/threonine kinase activity
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Biological Processanterograde axonal transport
Biological Processprotein phosphorylation
Biological Processsynaptic vesicle transport

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cyclin-dependent kinase 17
  • EC number
  • Alternative names
    • Cell division protein kinase 17
    • PCTAIRE-motif protein kinase

Gene names

    • Name
      pct-1
    • ORF names
      C07G1.3

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q8I7M8
  • Secondary accessions
    • G5EDS3

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Cell projection, axon
Note: Evenly distributed in the dendrite, the axon and the cell body of the DA motor neuron.

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis467In wy575; abnormal localization of several synaptic vesicle components and active zone proteins in the cell body and in the dendrite of DA9 motor neuron. No other phenotype except a slightly smaller progeny size.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004333901-667Cyclin-dependent kinase 17

Proteomic databases

Expression

Gene expression databases

    • WBGene00003961Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues

Interaction

Subunit

Interacts with cyy-1; the interaction is required to activate pct-1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q8I7M8cyy-1 P346242EBI-2918577, EBI-2696495

Complex viewer

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region1-70Disordered
Region85-184Disordered
Compositional bias99-144Acidic residues
Compositional bias148-164Polar residues
Domain328-609Protein kinase
Region642-667Disordered
Compositional bias644-667Basic residues

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8I7M8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    667
  • Mass (Da)
    76,153
  • Last updated
    2003-03-01 v1
  • Checksum
    8570731607218A3F
MTAYSPADSNAEARLLSGGSDPISDTENLLDLAYEVGTSSSDNTRYDRESENDEEEIGVGWEDTTSSSLNKRMCKSATFHDFCDDSEYSRRPVTTLHEEDFDEEEEDEFEDASDRRNLDEDDVEYEDEDDEDDIVVEEEEITPEDIEHSPTGVTTQTTPPSNNTSKSKKKKKRKSDEEDGLRKMKKSSTFASFLNMFVSRRRSGRDSGERLMSRSTCMLRPSISLSVVQESMILGSDGESVEVSPCTSDQTPTGVPPRYIVNVKMRQKTARKWSEEEIQKRLSLPADLRLPVAVVDKLNRTPTLDQPLTRKNRRASLSEIGFGKLETYEKLDKLGEGTYATVFRGRSILTNKFVALKEIRLEQEEGAPCTAIREVSLLRNLRHANVVTLHDIIHTDRLLTLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCHQRRVLHRDLKPQNLLITAKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMIAGRALFPGGTPTEQLGLIFRTLGSPRPDRHPTICEKPTFYPYANRHYNPDPLCRQIPRIDAHGFELLMKFLQYEGKDRVSAAEAVKHPFLRTIAVKCCHLRDEQSVLEADGIHIERELLASDHHHSSRRHHRGTLVKDKYRMHSSHHT

Q8I7M8-2

  • Name
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-225: MTAYSPADSNAEARLLSGGSDPISDTENLLDLAYEVGTSSSDNTRYDRESENDEEEIGVGWEDTTSSSLNKRMCKSATFHDFCDDSEYSRRPVTTLHEEDFDEEEEDEFEDASDRRNLDEDDVEYEDEDDEDDIVVEEEEITPEDIEHSPTGVTTQTTPPSNNTSKSKKKKKRKSDEEDGLRKMKKSSTFASFLNMFVSRRRSGRDSGERLMSRSTCMLRPSISL → MKKLKRRLSAAFRPGSNNNVSITSSGGSYYDSDCEGRNNIVIGYGMMSAPLHGRTWTLSESMSHLSDKNGAILEECAVVDPTALLRVSRGGTAGRRYDTNVNYINGMHVPPPRTHSLYYPRGYNSRRNSYYGSNA

Features

Showing features for alternative sequence, compositional bias.

Type
IDPosition(s)Description
Alternative sequenceVSP_0577631-225in isoform a
Compositional bias99-144Acidic residues
Compositional bias148-164Polar residues
Compositional bias644-667Basic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF129110
EMBL· GenBank· DDBJ
AAD37120.1
EMBL· GenBank· DDBJ
mRNA
FO080125
EMBL· GenBank· DDBJ
CCD61393.1
EMBL· GenBank· DDBJ
Genomic DNA
FO080125
EMBL· GenBank· DDBJ
CCD61395.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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