Q8I480 · ZNRF2_PLAF7
- ProteinRING finger protein PFE0100w
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1272 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Biotechnology
Possible candidate for an effective malaria vaccine as determined by epitope response in sera.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome | |
Cellular Component | HOPS complex | |
Cellular Component | membrane | |
Molecular Function | protein-macromolecule adaptor activity | |
Molecular Function | zinc ion binding | |
Biological Process | endosome organization | |
Biological Process | intracellular protein transport | |
Biological Process | organelle fusion | |
Biological Process | vacuole organization | |
Biological Process | vesicle docking involved in exocytosis | |
Biological Process | vesicle-mediated transport |
Keywords
- Ligand
Names & Taxonomy
Protein names
- Recommended nameRING finger protein PFE0100w
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)
Accessions
- Primary accessionQ8I480
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Single-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 771-791 | Helical | ||||
Sequence: IFIPLFLDNIDFLFMFIVKFL |
Keywords
- Cellular component
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000388770 | 1-1272 | UniProt | RING finger protein PFE0100w | |||
Sequence: MFNFRNLPLFDKDNSKDTDDIKNFINSYEGIYFSSSNKFINVFLDKILIIDPSSLNVITINTDLYVVDFLFNEKNKNLIVLGKGKNSLICSVYNIRECNFTLLKKIQLSKNINNIKKTLIAKCNEYIITLENKKITFYFLNKDYSINQSELIEDGKELIENIYLSKNHILLVIKNSYVYIYQLDIKNSHISYTLIDSFNLNLSYLRESINNKKKHINKINDVSNNDPKKDNNEKNTSSNNITHNNYNDISNNNNNNNNINGVKDHINNNTLENNDEPILSIYNEDLNVLYICQNMYNVLFVLNLNNLSFEFILLENKIINLFSCKFYLILLKEVNKKFFLHIYIIYEDMKLLVSTLLLNEPISNVIFFNNLFCLLIEEEISKPEIKVDKFYFYEQLKLKLHSKLDGDALKILKRDHVTNNINICKQEEKKYKLKNEQKDVEIYNKNNTVDSTNNTIYNSEVNHYKYITNDFFLNEDVNTDIKKELYNLNHTKDNINHDTLKKQTNQNDITMSLSKDEKNNDTNKFFNENMFTLNKFFKNCRNQIKIILKERNINEIINMFKKKKLYQWLIKYANLNKNYQIININFIHKIYADFLFEKEQYENAIYEYIQTINYLETSYVIHKYLNLDLYEYLTIYLEKLHVYHHFNDEHTMMLLSCYKKQCKKKKMISFIKKNKDKINLNKTYKFLLNAGYYNIVLNLSKKYKDHFTYVSILIEKYENYEKSLKYIFKLDVENICILLFKYGYKFIKYYPQLTIYLLKKIIKKYNINLTIFIPLFLDNIDFLFMFIVKFLDKNVNINKINHIQEKQKHHYSNMYHDSDELNSVTKQKNKINSFLLYEKDNNQNHNGIPSDSHNLSDDNNSQESTTAVNLINKTNLQLDIFNGEYDYILFVTVIQILLQKYKKSMQEENQTNNQSSKQTNNQSSKQTNKQSINQSNNQSINQTNNQSIKQTNIQTNKQKGNSTTNKIINKDETNEQNNILTFNIDKLIQNNKDKNINFLSVLLLSIYNYNKGLIYTSTQMNKYDISLLFSIHKFINNTKGKINKINMDEHKPNEQTMQINSSYKILNRNFQKVIYNICINHLKLNGSLSYNYIFYYLSMLNDEKYLIKFIKKIRQDMNLSIFNLIQILKKYNKSYSCIQNMVVAYMNDMNKNINDKCIEIEKDKKELEKIKKKQLKKKYNFYLIDNAYCSICKEILSVPMIHFLCKHSYHSYCLKDNNVCILCHNKDKEKKLLKEKAINSIQNFDEFFKYLQGSTDKFSYISNYLSYGITPK | |||||||
Modified residue (large scale data) | 818 | PTMeXchange | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 833 | PTMeXchange | Phosphoserine | ||||
Sequence: S |
Proteomic databases
Expression
Keywords
- Developmental stage
Structure
Family & Domains
Features
Showing features for compositional bias, region, repeat, coiled coil, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 216-233 | Basic and acidic residues | ||||
Sequence: INKINDVSNNDPKKDNNE | ||||||
Region | 216-260 | Disordered | ||||
Sequence: INKINDVSNNDPKKDNNEKNTSSNNITHNNYNDISNNNNNNNNIN | ||||||
Compositional bias | 234-260 | Polar residues | ||||
Sequence: KNTSSNNITHNNYNDISNNNNNNNNIN | ||||||
Repeat | 608-752 | CHCR | ||||
Sequence: YIQTINYLETSYVIHKYLNLDLYEYLTIYLEKLHVYHHFNDEHTMMLLSCYKKQCKKKKMISFIKKNKDKINLNKTYKFLLNAGYYNIVLNLSKKYKDHFTYVSILIEKYENYEKSLKYIFKLDVENICILLFKYGYKFIKYYPQ | ||||||
Region | 842-862 | Disordered | ||||
Sequence: NQNHNGIPSDSHNLSDDNNSQ | ||||||
Region | 908-970 | Disordered | ||||
Sequence: ENQTNNQSSKQTNNQSSKQTNKQSINQSNNQSINQTNNQSIKQTNIQTNKQKGNSTTNKIINK | ||||||
Coiled coil | 1146-1182 | |||||
Sequence: MNDMNKNINDKCIEIEKDKKELEKIKKKQLKKKYNFY | ||||||
Zinc finger | 1189-1224 | RING-type; atypical | ||||
Sequence: CSICKEILSVPMIHFLCKHSYHSYCLKDNNVCILCH |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,272
- Mass (Da)151,643
- Last updated2003-03-01 v1
- Checksum2940F2E5298C058B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 216-233 | Basic and acidic residues | ||||
Sequence: INKINDVSNNDPKKDNNE | ||||||
Compositional bias | 234-260 | Polar residues | ||||
Sequence: KNTSSNNITHNNYNDISNNNNNNNNIN |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL844504 EMBL· GenBank· DDBJ | CAD51386.1 EMBL· GenBank· DDBJ | Genomic DNA |