Q8I190 · SH3G3_DROVI

Function

function

Required presynaptically at the neuromuscular junction. Implicated in synaptic vesicle endocytosis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Cellular Componentglutamatergic synapse
Cellular Componentmembrane
Cellular Componenttype I terminal bouton
Molecular Functionlysophosphatidic acid acyltransferase activity
Molecular Functionphospholipid binding
Biological Processautophagosome assembly
Biological Processcellular response to starvation
Biological Processclathrin-dependent synaptic vesicle endocytosis
Biological Processmembrane bending
Biological Processmembrane tubulation
Biological Processplasma membrane tubulation
Biological Processregulation of synapse structure or activity
Biological Processsynaptic vesicle endocytosis
Biological Processsynaptic vesicle uncoating

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Endophilin-A
  • Alternative names
    • SH3 domain-containing GRB2-like protein

Gene names

    • Name
      EndoA
    • ORF names
      GJ14546

Organism names

  • Taxonomic identifier
  • Strains
    • Tucson 15010-1001.10
    • Tucson 15010-1051.87
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila

Accessions

  • Primary accession
    Q8I190
  • Secondary accessions
    • B4MC14

Proteomes

Subcellular Location

Cytoplasm
Membrane
; Peripheral membrane protein
Note: Associated with internal membranes. Expressed presynaptically at NMJs.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002858401-369Endophilin-A

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, region, compositional bias.

Type
IDPosition(s)Description
Domain18-248BAR
Coiled coil227-249
Region275-297Disordered
Compositional bias276-297Polar residues
Domain305-364SH3

Sequence similarities

Belongs to the endophilin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    369
  • Mass (Da)
    41,302
  • Last updated
    2003-03-01 v1
  • Checksum
    13083EBAFB655526
MAFAGLKKQINKANQYVTEKMGGAEGTKLDLDFMDMERKTDVTVELVEELQLKTKEFLQPNPTARAKMAAVKGISKLSGQAKSNTYPQPEGLLAECMLTYGKKLGEDNSVFAQALVEFGEALKQMADVKYSLDDNIKQNFLEPLHHMQTKDLKEVMHHRKKLQGRRLDFDCKRRRQAKDDEIRGAEDKFAESLQLAQVGMFNLLENDTEHVSQLVTFAEALYDFHSQCADVLRGLQETLQEKRAEAESRPRNEFVPKTLLDLNLDGGGGGLIDDGTPSHISSSASPLPSPMRSPAKSMAVTPNRQQQPCCQALYDFDPENPGELGFKENDIITLLNRVDDNWYEGAVNGRTGYFPQSYVQVQVPLPNGN

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0Q9WCP0A0A0Q9WCP0_DROVIDvir\endoA369

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias276-297Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY190955
EMBL· GenBank· DDBJ
AAO01081.1
EMBL· GenBank· DDBJ
Genomic DNA
CH940656
EMBL· GenBank· DDBJ
EDW58635.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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