Q8I113 · MNK_CAEEL

  • Protein
    MAP kinase-interacting serine/threonine-protein kinase mnk-1
  • Gene
    mnk-1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Serine/threonine-protein kinase which is required in the germline to positively regulate lifespan (PubMed:17277769).
May play a role in body wall muscle contraction (PubMed:25851606).
May be involved in embryonic cytokinesis (PubMed:19528325).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site209-217ATP (UniProtKB | ChEBI)
Binding site232ATP (UniProtKB | ChEBI)
Active site325Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionATP binding
Molecular Functioncalcium-dependent protein serine/threonine kinase activity
Molecular Functioncalcium/calmodulin-dependent protein kinase activity
Molecular Functioncalmodulin binding
Molecular Functionhistone H2AS1 kinase activity
Molecular Functionmetal ion binding
Molecular Functionprotein serine kinase activity
Biological Processbehavioral response to nicotine
Biological Processdetermination of adult lifespan
Biological Processintracellular signal transduction
Biological Processprotein phosphorylation
Biological Processregulation of protein deneddylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    MAP kinase-interacting serine/threonine-protein kinase mnk-1
  • EC number
  • Alternative names
    • MAP kinase integrating kinase-1

Gene names

    • Name
      mnk-1
    • ORF names
      R166.5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    Q8I113
  • Secondary accessions
    • Q22005

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Note: Predominantly localizes in the nucleus in the 1- and 2-cell embryos.

Keywords

Phenotypes & Variants

Disruption phenotype

RNAi-mediated knockdown causes a reduction in lifespan but not in a glp-4 bn2 mutant background. In an ife-2 ok306 mutant background, partially reduces the lifespan increase (PubMed:17277769).
In a rfl-1 or198 mutant background, partially rescues embryonic viability by restoring normal cytokinesis (PubMed:19528325).

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004386841-707MAP kinase-interacting serine/threonine-protein kinase mnk-1

Proteomic databases

Expression

Tissue specificity

Expressed in pharynx, intestine, vulva and body wall muscles.

Gene expression databases

    • WBGene00011304Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias1-28Polar residues
Region1-29Disordered
Region101-131Disordered
Domain203-493Protein kinase
Region589-628Disordered
Compositional bias594-615Polar residues
Region688-707Disordered

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q8I113-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    707
  • Mass (Da)
    78,934
  • Last updated
    2007-05-15 v2
  • Checksum
    43ACF06B41AA807E
MFFLDNTDSMTSSSRGITMPNTISSHEDVGGYSPRKVGIQHDYSAVGGGGAAFHHLHTSAATPRHVATSEFYDDEEATSPRGGIEIGAGGGKMMANLRRHRQRERETYEDEDVLSSSDESSGRPIPRYVGRDTDHVFGEFEMDDEDVVMRREDGYGEDETDEDYFDEEEPVAELLPLGGGTRRVPRTPGRKNSSKCGFFDYYKLTDEHLGSGAYGSVTTCKSIKSGVEYAVKIVDKQGETHSRKRILREVNIFKTCKDHPNIVQLLDWFEDETNFYLVMEKMRGGPLLQHILQRKYFTEEEARRVTKDISLALKFMHDRGIAHRDVKPENVLCTDPNHVSPVKLCDLDLASQRPPQHERHPLSQVASEPDLASPVGSAEFMAPEVVDAYVGDSLKYDKKCDTWSLGVILYIMLAGYAPFQGMCDDEDCGWSEGKPCEDCQQDLFHRIQDGYYEFPEEEWGMISEEAKDLVSNLLKRDPVDRFNADQILSHRWLQQSAASTILQTPSNLINRKDSARDVQQMSEHFNLMNRLADTRLSARFDNKMTMSECGSDLGTATIHGDGSFLSMGGEPFGTFPRKKSVGIAIEKSRSGEFTPPISRASPTTPPPSMLNLSEDLTDSPVKRRSADDSGTFSLFSPASSNGDDSICSPPMVFVDMPSIQLFGTGALLTSVQMTPRHTTEDDASLKSFEDEQENANPIHRIETQVNV

Q8I113-2

  • Name
    a
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 2-43: FFLDNTDSMTSSSRGITMPNTISSHEDVGGYSPRKVGIQHDY → TILHAGYPQSPVVHFGRHHNVNINQLNLNHLGQVDNIPNN

Features

Showing features for compositional bias, alternative sequence.

Type
IDPosition(s)Description
Compositional bias1-28Polar residues
Alternative sequenceVSP_0587072-43in isoform a
Compositional bias594-615Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284602
EMBL· GenBank· DDBJ
CAA90665.2
EMBL· GenBank· DDBJ
Genomic DNA
BX284602
EMBL· GenBank· DDBJ
CAD59152.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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