Q8I113 · MNK_CAEEL
- ProteinMAP kinase-interacting serine/threonine-protein kinase mnk-1
- Genemnk-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids707 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Serine/threonine-protein kinase which is required in the germline to positively regulate lifespan (PubMed:17277769).
May play a role in body wall muscle contraction (PubMed:25851606).
May be involved in embryonic cytokinesis (PubMed:19528325).
May play a role in body wall muscle contraction (PubMed:25851606).
May be involved in embryonic cytokinesis (PubMed:19528325).
Catalytic activity
- L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 209-217 | ATP (UniProtKB | ChEBI) | |||
Binding site | 232 | ATP (UniProtKB | ChEBI) | |||
Active site | 325 | Proton acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | ATP binding | |
Molecular Function | calcium-dependent protein serine/threonine kinase activity | |
Molecular Function | calcium/calmodulin-dependent protein kinase activity | |
Molecular Function | calmodulin binding | |
Molecular Function | histone H2AS1 kinase activity | |
Molecular Function | metal ion binding | |
Molecular Function | protein serine kinase activity | |
Biological Process | behavioral response to nicotine | |
Biological Process | determination of adult lifespan | |
Biological Process | intracellular signal transduction | |
Biological Process | protein phosphorylation | |
Biological Process | regulation of protein deneddylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMAP kinase-interacting serine/threonine-protein kinase mnk-1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ8I113
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
Disruption phenotype
RNAi-mediated knockdown causes a reduction in lifespan but not in a glp-4 bn2 mutant background. In an ife-2 ok306 mutant background, partially reduces the lifespan increase (PubMed:17277769).
In a rfl-1 or198 mutant background, partially rescues embryonic viability by restoring normal cytokinesis (PubMed:19528325).
In a rfl-1 or198 mutant background, partially rescues embryonic viability by restoring normal cytokinesis (PubMed:19528325).
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000438684 | 1-707 | MAP kinase-interacting serine/threonine-protein kinase mnk-1 | ||
Proteomic databases
Expression
Tissue specificity
Expressed in pharynx, intestine, vulva and body wall muscles.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-28 | Polar residues | |||
Region | 1-29 | Disordered | |||
Region | 101-131 | Disordered | |||
Domain | 203-493 | Protein kinase | |||
Region | 589-628 | Disordered | |||
Compositional bias | 594-615 | Polar residues | |||
Region | 688-707 | Disordered | |||
Sequence similarities
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q8I113-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Nameb
- Length707
- Mass (Da)78,934
- Last updated2007-05-15 v2
- Checksum43ACF06B41AA807E
Q8I113-2
- Namea
- Differences from canonical
- 2-43: FFLDNTDSMTSSSRGITMPNTISSHEDVGGYSPRKVGIQHDY → TILHAGYPQSPVVHFGRHHNVNINQLNLNHLGQVDNIPNN
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-28 | Polar residues | |||
Alternative sequence | VSP_058707 | 2-43 | in isoform a | ||
Compositional bias | 594-615 | Polar residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284602 EMBL· GenBank· DDBJ | CAA90665.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
BX284602 EMBL· GenBank· DDBJ | CAD59152.2 EMBL· GenBank· DDBJ | Genomic DNA |