Q8HXU0 · Q8HXU0_PRIMA

Function

function

Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionalpha2-adrenergic receptor activity
Molecular Functionepinephrine binding
Biological Processplatelet activation
Biological Processregulation of smooth muscle contraction
Biological Processregulation of vasoconstriction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Alpha-2B adrenergic receptor
  • Alternative names
    • Alpha-2B adrenoreceptor

Gene names

    • Name
      adra2B

Organism names

Accessions

  • Primary accession
    Q8HXU0

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane26-45Helical
Transmembrane65-85Helical
Transmembrane106-127Helical
Transmembrane147-172Helical
Transmembrane334-356Helical

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain6-373G-protein coupled receptors family 1 profile
Region181-296Disordered
Compositional bias208-217Polar residues

Sequence similarities

Keywords

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Fragment
  • Length
    373
  • Mass (Da)
    40,396
  • Last updated
    2003-03-01 v1
  • MD5 Checksum
    E9DD949F3FDF897EECD11742BEEF0C92
LFTIFGNALVILAVLTSRPLRAPQNLFLVSLAAADILVATFIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKRIILVVWLIAAAISLPPLVYKGDPGPQPRGRPQCKLNQEAWYILASSVGSFFAPCLIMILVYLRIYLIARRSHRRGPRAQGSSGDGEVRQPRSLPAGASATLPTLASSGTAAREANGHPKANGEGEEGETPEDPRPQDAPPGRPALPGGGQGPSEGACGASPQEEGEEPGPQAAASGATARSPPLQPAPGARVLATLRGQVLLGRGAGTAGAQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPRRCQVPHGLF

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias208-217Polar residues
Non-terminal residue373

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ427372
EMBL· GenBank· DDBJ
CAD20477.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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