Q8HBS8 · Q8HBS8_9SAUR

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Serpentes > Colubroidea > Colubridae > Colubrinae > Elaphe

Accessions

  • Primary accession
    Q8HBS8

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane24-50Helical
Transmembrane62-89Helical
Transmembrane122-140Helical
Transmembrane147-168Helical

Keywords

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-170Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    170
  • Mass (Da)
    18,510
  • Last updated
    2003-03-01 v1
  • Checksum
    6FA06BFE78C547B4
AGTGWTVYPPLSGNLVHSGPSVDLAIFSLHLAGASSILGAINFITTCINMKPKSMPMFNIPLFVWSVLITAIMLLLALPVLAAAITMLLTDRNLNTSFFDPCGGGDPVLFQHLFWFFGHPEVYILILPGFGIVSSIITFYTGKKNTFGYTSMIWAMMSIAILGFVVWAHH

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue170

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AY122723
EMBL· GenBank· DDBJ
AAM81041.1
EMBL· GenBank· DDBJ
Genomic DNA
AY122724
EMBL· GenBank· DDBJ
AAM81042.1
EMBL· GenBank· DDBJ
Genomic DNA
AY122725
EMBL· GenBank· DDBJ
AAM81043.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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