Q8H1U5 · APC2_ARATH
- ProteinAnaphase-promoting complex subunit 2
- GeneAPC2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids865 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of endoreduplication.
Pathway
Protein modification; protein ubiquitination.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Cellular Component | spindle | |
Molecular Function | ubiquitin protein ligase binding | |
Biological Process | cell division | |
Biological Process | megagametogenesis | |
Biological Process | protein ubiquitination | |
Biological Process | ubiquitin-dependent protein catabolic process |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAnaphase-promoting complex subunit 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ8H1U5
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Disruption phenotype
Gametophytic lethal phenotype.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 72 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000396838 | 1-865 | Anaphase-promoting complex subunit 2 | ||
Proteomic databases
Expression
Tissue specificity
Highly expressed in immature flowers. Expressed in stems, leaves and flowers.
Gene expression databases
Interaction
Subunit
The APC/C is composed of at least 10 subunits. Interacts with APC8, APC11, CDC27A and CDC27B.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q8H1U5 | APC11 Q9M9L0 | 4 | EBI-1749410, EBI-2130744 | |
BINARY | Q8H1U5 | APC8 Q9STS3 | 3 | EBI-1749410, EBI-2130714 | |
BINARY | Q8H1U5 | CDC27A Q06AN9 | 2 | EBI-1749410, EBI-1749373 | |
BINARY | Q8H1U5 | CDC27B Q8LGU6 | 3 | EBI-1749410, EBI-1668733 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length865
- Mass (Da)97,791
- Last updated2003-03-01 v1
- Checksum277D9DD60E4399C3
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 247 | in Ref. 3; BAC43061 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC006955 EMBL· GenBank· DDBJ | AAD22340.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002685 EMBL· GenBank· DDBJ | AEC05853.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK118453 EMBL· GenBank· DDBJ | BAC43061.1 EMBL· GenBank· DDBJ | mRNA | ||
AY138228 EMBL· GenBank· DDBJ | AAN10196.1 EMBL· GenBank· DDBJ | mRNA |